BACKGROUND: Spinal cord injury (SCI) is a severe central nervous system trauma. The present study aimed to evaluate the effect of HIF-1α on inflammation in spinal cord injury (SCI) to uncover the molecular mechanisms of anti-inflammation. RESULTS: HIF-1α was reduced in SCI model rats and HIF-1α activa...
Ávila, Caroline Nickel;
Trindade, Fernanda Moura Ribeiro;
Penteado, Júlia Oliveira;
Janke, Fernanda;
Schneider, Janaína Pereira;
Uecker, Júlia Neitzel;
Rincón, Joao Alveiro Alvarado;
Barros, Carlos Castilho de;
Andreazza, Robson;
Pieniz, Simone.
Abstract The present study aimed to evaluate the anti-inflammatory potential of a Lycium barbarum (L. barbarum) fruit extract in Wistar rats submitted to a palatable diet presenting systemic inflammation induced by lipopolysaccharides (LPS). Forty-two Wistar female rats (Rattus Novergicus) were used with...
Psoriasis is a chronic inflammatory skin disorder in humans, and the inflammatory reaction plays an important role in development and onset of psoriasis. 4'-O-β-D-glucosyl-5-O-methylvisamminol (4GMV) is one of the major active chromones isolated from Saposhnikoviae divaricata (Turcz.) Schischk, whic...
Cromonas,
Citocinas,
Dermatitis,
Glucósidos,
Imiquimod,
Inflamación,
Lipopolisacáridos,
Sistema de Señalización de MAP Quinasas,
Ratones Endogámicos BALB C,
FN-kappa B,
Psoriasis/inducido químicamente,
Psoriasis/tratamiento farmacológico
Porcaro, Antonio B;
Tafuri, Alessandro;
Sebben, Marco;
Novella, Giovanni;
Processali, Tania;
Pirozzi, Marco;
Amigoni, Nelia;
Rizzetto, Riccardo;
Shakir, Aliasger;
Brunelli, Matteo;
Cerruto, Maria Angela;
Migliorini, Filippo;
Siracusano, Salvatore;
Artibani, Walter.
ABSTRACT Objective To assess the association between prostate volume index (PVI), and prostatic chronic inflammation (PCI) as predictors of prostate cancer (PCA). PVI is the ratio between the central transition zone volume (CTZV) and the peripheral zone volume (PZV). Materials and methods Parameters ...
BACKGROUND Calotropis procera latex protein fraction (LP) was previously shown to protect animals from septic shock. Further investigations showed that LP modulate nitric oxide and cytokines levels. OBJECTIVES To evaluate whether the protective effects of LP, against lethal bacterial infection, is obse...
Antibacterianos/aislamiento & purificación,
Antibacterianos/farmacología,
Antibacterianos/uso terapéutico,
Calotropis/química,
Regulación hacia Abajo,
Homeostasis/efectos de los fármacos,
Inflamación/tratamiento farmacológico,
Látex/química,
Extractos Vegetales/farmacología,
Proteínas de Plantas/aislamiento & purificación,
Proteínas de Plantas/farmacología,
Proteínas de Plantas/uso terapéutico,
Infecciones por Salmonella/tratamiento farmacológico,
Infecciones por Salmonella/inmunología,
Infecciones por Salmonella/microbiología
BACKGROUND: Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hyper-proliferation and excessive inflammatory response are considered to be potential...
Santos, M J S;
Canuto, K M;
de Aquino, C C;
Martins, C S;
Brito, G A C;
Pessoa, T M R P;
Bertolini, L R;
de Sá Carneiro, I;
Pinto, D V;
Nascimento, J C R;
da Silva, B B;
Valença Jr, J T;
Guedes, M I F;
Owen, J S;
Oriá, R B.
Malnutrition is still considered endemic in many developing countries. Malnutrition-enteric infections may cause lasting deleterious effects on lipid metabolism, especially in children living in poor settings. The regional basic diet (RBD), produced to mimic the Brazilian northeastern dietary characteris...
Apolipoproteína A-I/sangre,
Apolipoproteína A-I/metabolismo,
Brasil,
Enfermedad Crónica,
Dieta/efectos adversos,
Inflamación/sangre,
Inflamación/metabolismo,
Inflamación/patología,
Hígado/metabolismo,
Desnutrición/sangre,
Desnutrición/metabolismo,
Desnutrición/patología,
Ratones Endogámicos C57BL
Ophiopogonin D (OP-D) is the principal pharmacologically active ingredient from Ophiopogon japonicas, which has been demonstrated to have numerous pharmacological activities. However, its protective effect against renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats remains unclear...
Pathophysiological mechanisms involved in orofacial pain and their relationship with emotional disorders have emerged as an important research area for multidisciplinary studies. In particular, temporomandibular disorders (TMD) have been evaluated clinically from both physiological and psychological pers...
Aydın, Emre;
Yıldırım, Yaşar;
Aydin, Fatma Yilmaz;
Bahadir, Mehmet Veysi;
Kaplan, Ibrahim;
Kadiroğlu, Berfin;
Ketani, Muzaffer Aydin;
Yilmaz, Zülfükar;
Kadiroğlu, Ali Kemal;
Yilmaz, Mehmet Emin.
Abstract INTRODUCTION: Sepsis is an important cause of mortality and morbidity, and inflammatory response and oxidative stress play major roles underlying its pathophysiology. Here, we evaluated the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in t...
Antiinflamatorios no Esteroideos/administración & dosificación,
Antiinflamatorios no Esteroideos/farmacología,
Modelos Animales de Enfermedad,
Etanercept/administración & dosificación,
Etanercept/farmacología,
Inflamación/patología,
Inflamación/prevención & control,
Inyecciones Intraperitoneales,
Riñón/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Ratas Sprague-Dawley,
Sepsis/sangre,
Sepsis/patología,
Factor de Necrosis Tumoral alfa/sangre
