ABSTRACT Introduction: The development of novel non-invasive biomarkers of kidney graft dysfunction, especially in the course of the delayed graft function period would be an important step forward in the clinical practice of kidney transplantation. Methods: We evaluated by RT-PCR the expression of miR...
Área Bajo la Curva,
Biomarcadores/análisis,
Biopsia,
Funcionamiento Retardado del Injerto/genética,
Funcionamiento Retardado del Injerto/patología,
Rechazo de Injerto/genética,
Trasplante de Riñón,
MicroARNs/análisis,
MicroARNs/genética,
Curva ROC,
Daño por Reperfusión/genética,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
ABSTRACT BACKGROUND: The chest pain classifications that are currently in use are based on studies that are several decades old. Various studies have indicated that these classifications are not sufficient for determining the origin of chest pain without additional diagnostic tests or tools. We describ...
Área Bajo la Curva,
Dolor en el Pecho/diagnóstico,
Dolor en el Pecho/fisiopatología,
Estudios Transversales,
Hospitales Públicos,
Isquemia Miocárdica/diagnóstico,
Isquemia Miocárdica/fisiopatología,
Dimensión del Dolor/métodos,
Reproducibilidad de los Resultados,
Medición de Riesgo/métodos,
Factores de Riesgo,
Sensibilidad y Especificidad,
Índice de Severidad de la Enfermedad,
Estadísticas no Paramétricas,
Centros de Atención Terciaria
Lycopene was reported to influence some cytochrome P450 enzymes activity. The present study investigates the effect of lycopene on the pharmacokinetics of paracetamol and chlorzoxazone. Lycopene (20 mg/kg) was intra-peritoneally administered to two groups of rats for eight consecutive days and two other ...
Nacif, Lucas S;
Rocha-Santos, Vinicius;
Claro, Laura C L;
Vintimilla, Agustin;
Ferreira, Leandro A;
Arantes, Rubens M;
Pinheiro, Rafael S;
Andraus, Wellington;
Alves, Venancio A F;
D'Albuquerque, Luiz Carneiro.
OBJECTIVES: The number of pancreatic transplants has decreased in recent years. Pancreatic grafts have been underutilized compared to other solid grafts. One cause of discard is the macroscopic appearance of the pancreas, especially the presence of fatty infiltration. The current research is aimed at und...
Tejido Adiposo/patología,
Tejido Adiposo/trasplante,
Área Bajo la Curva,
Biopsia,
Índice de Masa Corporal,
Estudios Transversales,
Hígado Graso/patología,
Hígado/patología,
Hígado/ultraestructura,
Páncreas/patología,
Trasplante de Páncreas,
Tejido Parenquimatoso/patología,
Estudios Prospectivos,
Sensibilidad y Especificidad,
Donantes de Tejidos/estadística & datos numéricos
Given that the pathogenesis of ankylosing spondylitis (AS) remains unclear, the aim of this study was to detect the potentially functional pathway cross-talk in AS to further reveal the pathogenesis of this disease. Using microarray profile of AS and biological pathways as study objects, Monte Carlo cros...
Área Bajo la Curva,
Bases de Datos Genéticas,
Perfilación de la Expresión Génica/métodos,
Expresión Génica,
Estudios de Asociación Genética,
Análisis por Micromatrices/métodos,
Método de Montecarlo,
Receptor Cross-Talk/fisiología,
Valores de Referencia,
Transducción de Señal/genética,
Espondilitis Anquilosante/genética
ABSTRACT Objective: To evaluate the gene expression of beta-trace protein in urine of diabetic patients, with no reduction in glomerular filtration rate, which was defined as below 60mL/min/1.73m2. Methods: Type 2 diabetes mellitus patients were recruited, and a group of non-diabetic individuals served...
Área Bajo la Curva,
Glucemia/metabolismo,
Estudios de Casos y Controles,
Estudios Transversales,
Diabetes Mellitus Tipo 2/genética,
Diabetes Mellitus Tipo 2/orina,
Expresión Génica,
Tasa de Filtración Glomerular,
Oxidorreductasas Intramoleculares/sangre,
Oxidorreductasas Intramoleculares/genética,
Oxidorreductasas Intramoleculares/orina,
Riñón/metabolismo,
Lipocalinas/sangre,
Lipocalinas/genética,
Lipocalinas/orina,
Persona de Mediana Edad,
Curva ROC,
Sensibilidad y Especificidad
Abstract Introduction Late-life depression (LLD) is common, but remains underdiagnosed. Validated screening tools for use with the oldest-old in clinical practice are still lacking, particularly in developing countries. Objectives To evaluate the accuracy of a screening tool for LLD in a community-dwel...
ABSTRACT Background and rationale. Many different non-invasive methods have been studied with the purpose of staging liver fibrosis. The objective of this study was verifying if transient elastography is superior to aspartate aminotransferase to platelet ratio index for staging fibrosis in patients with...
Aspartato Aminotransferasas/sangre,
Pruebas Enzimáticas Clínicas/métodos,
Diagnóstico por Imagen de Elasticidad/métodos,
Hepatitis C/sangre,
Hepatitis C/diagnóstico por imagen,
Cirrosis Hepática/sangre,
Cirrosis Hepática/diagnóstico por imagen,
Recuento de Plaquetas,
Área Bajo la Curva,
Biomarcadores/sangre,
Biopsia,
Hepatitis C/virología,
Cirrosis Hepática/virología,
Oportunidad Relativa,
Valor Predictivo de las Pruebas,
Pronóstico,
Curva ROC,
Reproducibilidad de los Resultados,
Índice de Severidad de la Enfermedad
BACKGROUND Amphimerus spp. is a liver fluke that infects humans and domestic animals. It is highly prevalent in some Ecuadorian communities. Currently, diagnosis is based on the microscopic observation of eggs in faeces, but this has variable sensitivity. More sensitive methods are needed for diagnostic ...
Correia, Luis Cláudio Lemos;
Cerqueira, Maurício;
Carvalhal, Manuela;
Ferreira, Felipe;
Garcia, Guilherme;
Silva, André Barcelos da;
Sá, Nicole de;
Lopes, Fernanda;
Barcelos, Ana Clara;
Noya-Rabelo, Márcia.
Abstract Background: Currently, there is no validated multivariate model to predict probability of obstructive coronary disease in patients with acute chest pain. Objective: To develop and validate a multivariate model to predict coronary artery disease (CAD) based on variables assessed at admission to...
Enfermedad Aguda,
Factores de Edad,
Área Bajo la Curva,
Dolor en el Pecho/clasificación,
Dolor en el Pecho/diagnóstico,
Dolor en el Pecho/tratamiento farmacológico,
Angiografía Coronaria,
Enfermedad de la Arteria Coronaria/diagnóstico,
Enfermedad de la Arteria Coronaria/diagnóstico por imagen,
Enfermedad de la Arteria Coronaria/mortalidad,
Electrocardiografía/métodos,
Modelos Estadísticos,
Análisis Multivariante,
Nitratos/uso terapéutico,
Valor Predictivo de las Pruebas,
Sensibilidad y Especificidad,
Factores Sexuales,
Troponina/sangre
