Cardiovascular disease(CVD) remains the major cause of mortality in the world, typically claiming a third of all deaths. The primary cause of CVD is atherosclerosis. Therefore, timely prevention and therapy of atherosclerosis are able to reduce the risk of the development of its clinical manif...
Aterosclerosis/dietoterapia,
Dieta Aterogénica/métodos,
Aceite de Oliva/farmacología,
Colesterol/farmacología,
Dieta Alta en Grasa/métodos,
Estrés Oxidativo/inmunología,
Glutatión/farmacología,
Peroxidación de Lípido/inmunología,
Triglicéridos/farmacología,
Hipercolesterolemia/inmunología,
Lipoproteínas/inmunología,
Ratas Wistar/inmunología
Introdução: A aterosclerose é uma doença inflamatória crônica decorrente de alterações na parede das artérias de médio e grande calibre e associadas a diversos fatores de risco, dentre os quais destaca-se as hiperlipidemias, ou seja, o aumento plasmático das lipoproteínas, mas também outras ...
Inmunomodulación,
Aterosclerosis/patología,
Inmunización/instrumentación,
Anticuerpos Monoclonales/efectos adversos,
Arterias/anomalías,
Dieta/clasificación,
Células Productoras de Anticuerpos/clasificación,
Enfermedades Cardiovasculares/patología,
Factores de Riesgo,
Indolamina-Pirrol 2,3,-Dioxigenasa/administración & dosificación
Introdução: A aterosclerose é uma doença inflamatória crônica decorrente de alterações na parede das artérias de médio e grande calibre e associadas a diversos fatores de risco, dentre os quais destaca-se as hiperlipidemias, ou seja, o aumento plasmático das lipoproteínas, mas também outras ...
Growing evidence indicates that oxidative stress plays an important role in the pathophysiology of many cardiovascular diseases, including atherosclerosis. In this context, the use of bioactive compounds with antioxidant action can bring health benefits, especially in the prevention and control of pathop...
Cardiovascular diseases (CVDs) are the main cause of mortality worldwide, being the ischemic heart disease responsible for 85% of deaths. Atherosclerosis is a chronic inflammation of the arteries that underlies ischemic forms of CVD and involves the innate and adaptive immune systems, from initial fatty ...
Ácidos Docosahexaenoicos/análisis,
Nanocápsulas/análisis,
Aterosclerosis/patología,
Placa Aterosclerótica/metabolismo,
Antiinflamatorios/administración & dosificación,
Arterias/anomalías,
Causalidad,
Enfermedades Cardiovasculares/clasificación,
Estrategias de Salud,
Molécula-1 de Adhesión Celular Endotelial de Plaqueta,
Nanopartículas,
Preparaciones Farmacéuticas/análisis
Resumo Fundamento Foi demonstrado que as subunidades de interleucina-35 (IL-35) estão fortemente expressas nas placas ateroscleróticas em humanos. Assim, considera-se que elas têm um papel na aterosclerose. Objetivos Neste estudo, os níveis de IL-35 foram comparados com o grupo controle em pacien...
Aterosclerosis/complicaciones,
Aterosclerosis/prevención & control,
Dislipidemias/tratamiento farmacológico,
Dislipidemias/prevención & control,
Factores de Riesgo de Enfermedad Cardiaca,
Diabetes Mellitus/diagnóstico,
Accidente Cerebrovascular/prevención & control,
Tabaquismo/prevención & control,
Hipertensión/terapia,
Tomografía Computarizada por Rayos X/métodos,
Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico,
HDL-Colesterol/toxicidad,
LDL-Colesterol/toxicidad
Abstract Metabolic syndrome (MetS), an epidemic defined as a group of interconnected physiological, biochemistry, clinical, and metabolic factors, directly increases the risk of cardiovascular disease, atherosclerosis, type 2 diabetes, and death. MetS therapy includes diet, physical exercise, and a poly-...
SUMMARY: Statins inhibit cholesterol synthesis, but also have other pleiotropic effects. There are indications that they affect macrophage survival trough the regulation of apoptosis. We analyzed 50 samples of aortic wall, selected based on statins in patients' therapy (n=25, Th-S group) or statin-free t...
Inhibidores de Hidroximetilglutaril-CoA Reductasas/administración & dosificación,
Aterosclerosis/metabolismo,
Apoptosis/efectos de los fármacos,
Proteína bcl-X/metabolismo,
Genes bcl-2/fisiología,
Macrófagos/efectos de los fármacos,
Aorta/efectos de los fármacos,
Aterosclerosis/tratamiento farmacológico,
Placa Aterosclerótica,
Factores de Riesgo,
Medición de Riesgo