LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Sox2 function as a negative regulator to control HAMP expression

Song, Bin; Bian, Qi; Shao, Cheng-Hao; Liu, An-An; Jing, Wei; Liu, Rui; Zhang, Yi-Jie; Zhou, Ying-Qi; Li, Gang; Jin, Gang.

Biol. Res; 48 (), 2015

BACKGROUND: Hepcidin, encoding by HAMP gene, is the pivotal regulator of iron metabolism, controlling the systemic absorption and transportation of irons from intracellular stores. Abnormal levels of HAMP expression alter plasma iron parameters and lead to iron metabolism disorders. Therefore,itis animpo...

Regulación Neoplásica de la Expresión Génica/genética, Hepatocitos/metabolismo, Hepcidinas/genética, Factores de Transcripción SOXB1/genética, Anemia/genética, Anemia/metabolismo, Proteína Morfogenética Ósea 2/metabolismo, Hepcidinas/metabolismo, Interleucina-6/metabolismo, Hierro/metabolismo, Plásmidos/genética, Regiones Promotoras Genéticas/genética, Factores de Transcripción SOXB1/metabolismo, Sitios de Unión, Técnicas de Silenciamiento del Gen, Vectores Genéticos, Células Hep G2, Luciferasas

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Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancer cells

Guo, Jian-Ru; Chen, Qian-Qian; Lam, Christopher Wai-Kei; Zhang, Wei.

Biol. Res; 48 (), 2015

BACKGROUND: We have investigated the potential anticancer effects of karanjin, a principal furanoflavonol constituent of the Chinese medicine Fordia cauliflora, using cytotoxic assay, cell cycle arrest, and induction of apoptosis in three human cancer cell lines (A549, HepG2 and HL-60 cells). RESULTS: MT...

Antineoplásicos Fitogénicos/farmacología, Apoptosis/efectos de los fármacos, Benzopiranos/farmacología, Puntos de Control del Ciclo Celular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos, Fabaceae/química, Extractos Vegetales/farmacología, Benzopiranos/aislamiento & purificación, Células A549, Células HL-60, Células Hep G2

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miR-205 promotes proliferation and invasion of laryngeal squamous cell carcinoma by suppressing CDK2AP1 expression

Zhong, Gang; Xiong, Xingao.

Biol. Res; 48 (), 2015

BACKGROUND: The aberrant expression of microRNAs (miRNAs) has been found in various types of cancer. miR-205 was reported to be upregulated in laryngeal squamous cell carcinoma (LSCC) tissues, however, the mechanisms by which miR-205 functions as a regulator of LSCC are largely unknown. RESULTS: In this ...

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