SUMMARY OBJECTIVES This study was conducted to reveal the possible protective effects of ticagrelor and enoxaparin pretreatment against ischemia-reperfusion (IR)-induced injury on the lung tissue of a rat model. METHODS Wistar albino rats were randomly divided into 4 groups as follows: group-1 (contr...
Aorta Abdominal/cirugía,
Apoptosis/efectos de los fármacos,
Caspasa 3/metabolismo,
Modelos Animales de Enfermedad,
Enoxaparina/farmacología,
Pulmón/efectos de los fármacos,
Pulmón/patología,
Lesión Pulmonar/prevención & control,
Sustancias Protectoras/farmacología,
Distribución Aleatoria,
Ratas Wistar,
Daño por Reperfusión/patología,
Daño por Reperfusión/prevención & control,
Ticagrelor/farmacología
ABSTRACT PURPOSE: We examined the effect of intracameral administration of cefuroxime on oxidative stress and endothelial apoptosis in rat corneal tissue. METHODS: In total, 30 rats were divided into 3 groups of 10 rats each (intracameral administration of cefuroxime 0.1 mg/0.01 mL (cefuroxime group); ...
Antibacterianos/farmacología,
Apoptosis/efectos de los fármacos,
Arildialquilfosfatasa/análisis,
Hidrolasas de Éster Carboxílico/análisis,
Caspasa 3/análisis,
Caspasa 8/análisis,
Cefuroxima/farmacología,
Córnea/efectos de los fármacos,
Córnea/metabolismo,
Córnea/patología,
Endotelio Corneal/efectos de los fármacos,
Endotelio Corneal/metabolismo,
Endotelio Corneal/patología,
Inmunohistoquímica,
Inyecciones Intraoculares,
Oxidantes/sangre,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar,
Reproducibilidad de los Resultados
SUMMARY: Reproductive dysfunction is a complication for many diseases and toxins. Its early diagnosis and treatment are immensely important. Here the morphological histoarchitecture changes in early testicular and cauda toxicity before and after treatment with angiotensin receptor blockers were evaluated...
Losartán/farmacología,
Bencimidazoles/farmacología,
Tetrazoles/farmacología,
Bloqueadores del Receptor Tipo 1 de Angiotensina II/farmacología,
Testículo/efectos de los fármacos,
Tioacetamida/toxicidad,
Inmunohistoquímica,
Testosterona/análisis,
Ratas Sprague-Dawley,
Antígeno Nuclear de Célula en Proliferación/metabolismo,
Caspasa 3/metabolismo,
Testículo/patología,
Malondialdehído/análisis,
Glutatión/análisis
Abstract Lafoensia pacari A. St. Hill has been used in traditional medicine as an anti-ulcerogenic and anti-inflammatory. Although there is an ethnopharmacological indication for cancer treatment, only a few studies have demonstrated its possible anticancer activity. Thus, the aims of this study were: (1...
BACKGROUND: Recent evidences indicated that some local anaesthetic agents played a role in inhibiting the proliferation of cancer cells; Whether ropivacaine is able to promote apoptosis of hepatocellular carcinoma (HCC) cells is still unclear. The aim of this study was to investigate the effect of ropiva...
Anestésicos Locales/farmacología,
Apoptosis/efectos de los fármacos,
Carcinoma Hepatocelular/patología,
Caspasa 3/metabolismo,
Neoplasias Hepáticas/patología,
Ropivacaína/farmacología,
Apoptosis/fisiología,
Carcinoma Hepatocelular/metabolismo,
Proliferación Celular/efectos de los fármacos,
Neoplasias Hepáticas/metabolismo,
Mitocondrias/efectos de los fármacos,
Transducción de Señal/efectos de los fármacos,
Línea Celular Tumoral,
Citometría de Flujo,
Microscopía Confocal,
Microscopía Fluorescente
Abstract Objective To determine the role of caspase-3, apoptosis-inducing factor (AIF), and Bcell lymphoma-2 (Bcl-2) expressions in term premature rupture of membrane (PROM). Methods An analytic observational study with case-control design was conducted, involving 52 subjects (37-42 weeks of gestatio...
Qi, Xiao-Lin;
Hao, Jian;
Huang, Lian-Jiang;
Wu, Sheng;
Ma, Hong-Hao;
Ye, Zhang-Qing;
He, Hui-Bo;
Li, Shu-Wen;
Li, Cheng-En;
Huang, Xin.
Abstract Purpose: To investigate the apoptotic mechanisms in rabbits with blast-induced acute lung injury (ALI). Methods: A total of 40 rabbits were randomly divided into a blank control group (A, n=10) and an experimental group (EXP, n=30). Explosion-induced chest-ALI models were prepared and sampled...
Lesión Pulmonar Aguda/sangre,
Lesión Pulmonar Aguda/patología,
Lesión Pulmonar Aguda/fisiopatología,
Apoptosis/fisiología,
Traumatismos por Explosión/sangre,
Traumatismos por Explosión/patología,
Traumatismos por Explosión/fisiopatología,
Caspasa 3/sangre,
Modelos Animales de Enfermedad,
Proteínas Proto-Oncogénicas c-bcl-2/sangre,
Alveolos Pulmonares/patología,
Distribución Aleatoria,
Proteína X Asociada a bcl-2/sangre
La reserpina es un antipsicótico e hipotensor arterial que reduce significativamente los niveles de monoaminas centrales, y también es utilizada para modelar los cuadros depresivos humanos en animales de laboratorio. Este trabajo estudió, en ratas Wistar machos adolescentes, cómo la reserpina afecta ...
Abstract Background In this study, we aimed to investigate the effect of dexmedetomidine on colistin nephrotoxicity in rats. Methods Thirty-two Wistar albino rats were allocated into four groups. Intraperitoneal (ip) saline at 1 mL.kg-1 was administered to the control group and 10 mg.kg-1 ip colistin w...
Abstract Objective: Melatonin has a protective role in adults with cardiovascular disease, but the effects of melatonin in children with cardiac dysfunction are not well understood. This study was designed to explore the variations in melatonin, myeloperoxidase, and caspase-3 levels in children sufferin...
