Results: 274

Asymmetric Opening of Mitochondrial Permeability Transition Pore in Mouse Brain Hemispheres: A Link to the Mitochondrial Calcium Uniporter Complex

Abstract The prolonged entry of large amounts of calcium into the mitochondria through the mitochondrial calcium uniporter complex (MCUC) may cause the permeability transition pore (mPTP) to open, which contributes to the pathogenesis of several diseases. Tissue-specific differences in mPTP opening due t...

Piracetam-induced neuroprotection in lipopolysaccharides-challenged EOC-20 cells and mouse brain via attenuating oxidative stress

Abstract Therapeutically, piracetam has been used for decades as a cognitive enhancer for memory- related neuronal disorders. The present study aimed to investigate the neuroprotective potential of piracetam on lipopolysaccharides (LPS)-induced neuronal deficit using both in-vitro and in-vivo experimenta...

Neuroscience of consciousness: cognition, physics and philosophy of decoding the human brain

The biophysical roots of consciousness have been the subject of an ongoing debate for centuries. In order to understand the data, create novel experimental methodologies, and increase our ability to investigate this phenomenon of interest, the proposed theories must lead to empirical, repeatable, and tes...

The arterial circle described by Willis, and the contribution of his predecessors

Rev. bras. neurol; 57 (4), 2021
The description of arteries at the base of the human brain forming an ‘arterial circle’, named after Thomas Willis, has had a long history after the restoration of human dissection, partly due to the studies of many outstanding anatomists that preceded Willis. He provided, with the collaboration of R...

Revascularizacion cerebral en el moyamoya del adulto

Rev. argent. neurocir; 35 (3), 2021
Introducción: el Moyamoya (MM) es una enfermedad crónica esteno-oclusiva de los vasos arteriales intracraneanos asociado al desarrollo secundario de arteriolas dilatadas en la base del cerebro. La historia natural de la enfermedad predispone a infartos y/o hemorragias cerebrales. El objetivo del presen...

Modelo de simulación de clipado de aneurismas cerebrales de bajo costo, validez aparente y de contenido

Rev. argent. neurocir; 35 (3), 2021
Objetivo: Presentar un modelo de entrenamiento realista en clipado microquirúrgico de aneurisma cerebral con flujo pulsátil, artificial, accesible y de bajo costo. Evaluar su validez aparente y de contenido. Introducción: La tendencia actual hacia el tratamiento endovascular de aneurismas cerebrales p...

“Este caso me desorientó”

Rev. argent. neurocir; 35 (3), 2021
Paciente femenina de 2 años, sin antecedentes de relevancia, quien consultó en otro centro por cuadro de diarrea, vómitos y fiebre de 5 días de evolución, asociado a bradipsiquia y tendencia al sueño. A su ingreso se solicitó tomo-grafía computada de cerebro (TC), evidenciando ventrícu...

A Simple Method to Avoid Brain Shift during Neuronavigation: Technical Note

Arq. bras. neurocir; 40 (1), 2021
Introduction The precise identification of anatomical structures and lesions in the brain is the main objective of neuronavigation systems. Brain shift, displacement of the brain after opening the cisterns and draining cerebrospinal fluid, is one of the limitations of such systems. Objective To describe ...

Clinical and radiological features of main dementias

Rev. bras. neurol; 57 (2), 2021
Dementia is a syndrome characterized by a decline of two or more cognitive functions, affecting social or professional life. Alzheimer’s Disease is a neurodegenerative disorder that represents 53% of dementia cases; memory loss, inability to recognize faces, impaired judgement, disorientation and confu...