Abstract In recent years, improvements have been made, through biotechnological processes, in the production and development of peptides capable of increasing collagen and elastin synthesis for anti-aging skin care. However, proteins have many limitations due to their structural, chemical and physical fr...
The viscera and other residues from fish processing are commonly discarded by the fishing industry. These byproducts can be a source of digestive enzymes with industrial and biotechnological potential. In this study, we aimed at the extraction, characterization, and application of acidic proteases from t...
Alpha amylase, catalyzing the hydrolysis of starch is a ubiquitous enzyme with tremendous industrial applications. A 1698 bp gene coding for 565 amino acid amylase was PCR amplified from Geobacillus thermodenitrificans DSM465, cloned in pET21a (+) plasmid, expressed in BL21 (DE3) strain of E. coli and ch...
L-Asparaginase catalysing the breakdown of L-Asparagine to L-Aspartate and ammonia is an enzyme of therapeutic importance in the treatment of cancer, especially the lymphomas and leukaemia. The present study describes the recombinant production, properties and anticancer potential of enzyme from a hypert...
Antineoplásicos/farmacología,
Asparaginasa/biosíntesis,
Asparaginasa/farmacología,
Células CACO-2,
Estabilidad de Enzimas,
Escherichia coli/genética,
Concentración de Iones de Hidrógeno,
Simulación del Acoplamiento Molecular,
Pyrococcus abyssi/enzimología,
Proteínas Recombinantes/biosíntesis,
Proteínas Recombinantes/farmacología,
Especificidad por Sustrato
Abstract A stability indicating UPLC method has been developed and validated for the simultaneous determination of fosnetupitant and palonosetron in bulk and in injection dosage form. This combination is used for the prevention of acute and delayed nausea and vomiting associated with initial and repeated...
Abstract Two polyurethane foam-based sorbents (PUF) were synthesized by imprinting and grafting techniques and examined for selective separation and preconcentration of caffeine (CAF) in some pharmaceutical products and in black tea. Molecularly imprinted PUF was synthesized based on hydrogen-bonding in...
Abstract This study aimed to develop promising and innovative mucoadhesive gel systems containing dexamethasone-loaded nanoparticle to increase the effectiveness of treatment for oral precancerous lesions and to reduce side effects. In this respect, a dexamethasone-loaded nanoparticle formulation was pre...
Antisépticos Bucales/análisis,
Dexametasona/agonistas,
Neoplasias de la Boca/prevención & control,
Nanopartículas/clasificación,
Administración Bucal,
Administración a través de la Mucosa,
Carcinoma/clasificación,
Concentración de Iones de Hidrógeno,
Geles/efectos adversos,
Liberación de Fármacos,
Preparaciones Farmacéuticas/administración & dosificación,
Técnicas In Vitro/métodos
Introduction: Pharmaceutical pediatric formulations with low in pH and high in total titratable acidicity used frequently and over long periods of time, have the potential to produce erosive lesions in teeth. On the other hand, high concentration of sucrose, the nocturnal use and the lack of hygiene afte...
Abstract The main purposes of the current study were to formulate o/w nanoemulsions as a carrier for Tamarindus indica (tamarind) fruit pulp extract and to study the antioxidant and antibacterial potentials of nanoemulsions containing tamarind extract, focusing on cosmetic/hygiene applications. The o/w n...
En la investigación se determinaron la presencia de geohelmintos y se evaluó la calidad ambiental del suelo mediante parámetros fisicoquímicos en el distrito de José Crespo y Castillo – Huánuco, Perú. Se detectaron y cuantificaron los geohelmintos, se caracterizó los perfiles modales y propieda...
