LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons

Koriauli, S; Natsvlishvili, N; Barbakadze, T; Mikeladze, D.

Biol. Res; 48 (), 2015

BACKGROUND: In the central nervous system, interleukin-10 (IL-10) provides trophic and survival effects directly on neurons, modulates neurite plasticity, and has a pivotal importance in the neuronal regeneration in neurodegenerative and neuroinflammatory conditions. This cytokine is primarily produced b...

Encéfalo/metabolismo, Ácido Glutámico/metabolismo, Interleucina-10/genética, NADPH Oxidasas/metabolismo, Receptores sigma/metabolismo, Membrana Celular/metabolismo, Retículo Endoplásmico/metabolismo, Proteínas de Choque Térmico/metabolismo, Receptores de Inositol 1,4,5-Trifosfato/metabolismo, Neuronas/metabolismo, Especies Reactivas de Oxígeno/análisis, Especies Reactivas de Oxígeno/metabolismo, Receptores de N-Metil-D-Aspartato/metabolismo, Receptores de N-Metil-D-Aspartato/clasificación, Receptores sigma/agonistas, Receptores sigma/clasificación, Proteína de Unión al GTP rac1/metabolismo, Técnicas de Silenciamiento del Gen, Inmunoprecipitación, Ratones Endogámicos C57BL

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Disease association and inter-connectivity analysis of human brain specific co-expressed functional modules

BACKGROUND: In the recent studies, it is suggested that the analysis of transcriptomic change of functional modules instead of individual genes would be more effective for system-wide identification of cellular functions. This could also provide a new possibility for the better understanding of differenc...