ABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25,...
Antioxidantes/farmacología,
Antioxidantes/uso terapéutico,
Antiparkinsonianos/farmacología,
Antiparkinsonianos/uso terapéutico,
Cimenos,
Modelos Animales de Enfermedad,
Peroxidación de Lípido/efectos de los fármacos,
Trastornos de la Memoria/tratamiento farmacológico,
Trastornos de la Memoria/fisiopatología,
Memoria a Corto Plazo/efectos de los fármacos,
Monoterpenos/farmacología,
Monoterpenos/uso terapéutico,
Actividad Motora/efectos de los fármacos,
Neuralgia/tratamiento farmacológico,
Neuralgia/fisiopatología,
Oxidopamina,
Enfermedad de Parkinson/tratamiento farmacológico,
Enfermedad de Parkinson/fisiopatología,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Compuestos de Sulfhidrilo/análisis
Resumen
INTRODUCCIÓN: Muchos pacientes con enfermedad de Parkinson tienen una respuesta limitada con el tratamiento farmacológico convencional. Se ha postulado el uso de células madre como una alternativa, aunque su efectividad sigue siendo un tema de controversia.
MÉTODOS: Para responder esta pregu...
Abstract AIMS to compare the efficacy of neurofunctional training versus resistance training in improving gait and quality of life among patients with PD METHODS This randomized controlled trial included 40 participants randomly assigned to two groups through random number table generator: resistance t...
OBJECTIVE: To verify the effect of an endurance exercise program in middle stages of Parkinson's disease. METHODS: The patients were two women and seven men with Parkinson's disease, aged 56 to 74 years, classified at Hoehn and Yahr stages 2 to 2.5. The study was designed as an open long-term pilot tria...
ABSTRACT Objective To investigate which factors are associated with the quality of life decline in Parkinson's disease patients from mild to moderate stages. Methods The Unified Parkinson's Disease Rating Scale and Parkinson's Disease Questionnaire-39 were used to evaluate clinical/functional data an...
ABSTRACT The Bereitschaftspotential (BP) is a negative wave observed in EEG retrograde averaging, preceding a motor act. The objective was to study the BP preceding voluntary eyelid blinks in Parkinson's disease (PD) patients during off and on phases of levodopa. Methods Ten PD patients in stages 1 and...
Análisis de Varianza,
Antiparkinsonianos/efectos adversos,
Parpadeo/fisiología,
Estudios de Casos y Controles,
Variación Contingente Negativa/fisiología,
Electrodos Implantados,
Electroencefalografía,
Párpados/fisiología,
Hipocinesia/etiología,
Levodopa/efectos adversos,
Corteza Motora/fisiología,
Movimiento/fisiología,
Enfermedad de Parkinson/tratamiento farmacológico,
Enfermedad de Parkinson/fisiopatología,
Factores de Tiempo
ABSTRACT Subthalamic nucleus deep brain stimulation (STN-DBS) is a surgical technique to treat motor symptoms in patients with Parkinson’s disease (PD). Studies have shown that STN-DBS may cause a decline in verbal fluency performance. We aimed to verify the effects of STN-DBS on the performance of...
RESUMO Objetivo Caracterizar o perfil da fluência da fala de indivíduos com Doença de Parkinson em diferentes tarefas de fala. Método Participaram do estudo 40 indivíduos, de 40 a 80 anos de idade, de ambos os gêneros, divididos em 2 grupos: GP (grupo pesquisa - 20 indivíduos com diagnóstico de...
Estudios de Casos y Controles,
Estudios Transversales,
Escolaridad,
Persona de Mediana Edad,
Enfermedad de Parkinson/complicaciones,
Enfermedad de Parkinson/fisiopatología,
Lectura,
Valores de Referencia,
Índice de Severidad de la Enfermedad,
Habla/fisiología,
Medición de la Producción del Habla/métodos,
Estadísticas no Paramétricas,
Tartamudeo/etiología,
Tartamudeo/fisiopatología,
Factores de Tiempo
Objetivo: Identificar e comparar as pessoas com Doença de Parkinson (DP) que fazem atividades multidisciplinares com aqueles que não fazem. Método: Os participantes foram avaliados quanto ao estadiamento Hoehn e Yahr (HY) (1-4), idade, dose diária de levodopa, que atividades que participa, qualidade ...
ABSTRACT Objective Patients with Parkinson’s disease (PD) may present with unusual motor and non-motor symptoms and signs in the early stage of the disease. Methods Cases were collected over a five-year period at two tertiary movement disorders clinics. All had a diagnosis of PD with unusual pr...
Brasil,
Diagnóstico Precoz,
Hipocinesia/diagnóstico,
Hipocinesia/fisiopatología,
Actividad Motora/fisiología,
Trastornos Motores/diagnóstico,
Trastornos Motores/fisiopatología,
Enfermedad de Parkinson/diagnóstico,
Enfermedad de Parkinson/fisiopatología,
Estudios Retrospectivos,
Evaluación de Síntomas,
Temblor/diagnóstico,
Temblor/fisiopatología
