Abstract Purpose: To investigated the effects of ginsenoside Rb1 on diabetic retinopathy in streptozotocin-induced diabetic rats. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin (80 mg/kg) in male Wistar rats. Ginsenoside Rb1 (20, 40 mg/kg) was injected (i.p.) on...
ABSTRACT Objective: To investigate the anti-hyperglycemic effects of Plathymenia reticulata hydroalcoholic extract and related changes in body weight, lipid profile and the pancreas. Methods: Diabetes was induced in 75 adult male Wistar rats via oral gavage of 65mg/Kg of streptozotocin. Rats were alloc...
Glucemia/análisis,
Peso Corporal/efectos de los fármacos,
Colesterol,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Fabaceae,
Hiperplasia/patología,
Hipoglucemiantes/farmacología,
Fitoterapia,
Extractos Vegetales/farmacología,
Hojas de la Planta,
Ratas Wistar,
Estreptozocina
Farias, V X;
Uchoa, P N;
Aquino, C P;
Britto, L R G;
Fonteles, M C;
Leal-Cardoso, J H;
Silva-Alves, K S;
Havt, A;
Prata, M M G;
Heimark, D B;
Nascimento, N R F;
Santos, C F.
The transport of myo-inositol is the main mechanism for the maintenance of its high intracellular levels. We aimed to measure the mRNA and protein levels of myo-inositol cotransporters in the sciatic nerve (SN) and dorsal root ganglia (DRG) during experimental diabetes. Streptozotocin-induced (STZ; 4, 8,...
OBJECTIVE: To test whether swimming training benefits femoral neck strength in young diabetic rats under insulin therapy. METHODS: A total of 60 male Wistar rats (age: 40 days) were divided equally into the following six groups: control sedentary, control exercise, diabetic sedentary, diabetic exercise,...
Glucemia/análisis,
Peso Corporal/fisiología,
Hueso Esponjoso/fisiopatología,
Colágeno/análisis,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/fisiopatología,
Terapia por Ejercicio/métodos,
Cuello Femoral/fisiopatología,
Fracturas Óseas/fisiopatología,
Fracturas Óseas/prevención & control,
Hipoglucemiantes/uso terapéutico,
Insulina/uso terapéutico,
Condicionamiento Físico Animal/fisiología,
Ratas Wistar,
Reproducibilidad de los Resultados,
Estreptozocina,
Natación/fisiología,
Factores de Tiempo
Abstract Purpose: To evaluate if Moringa oleifera leaf aqueous extract (ME) influences the healing of skin wounds of diabetic rats. Methods: Wistar rats were used (6 rats/group). Group 1 received normal saline (NS) v.o. Group 2 received moringa extract (100mg/kg v.o) for 3 weeks. Groups 3 and 4: Stre...
Abstract Purpose: To investigate the specific molecular mechanisms and effects of curcumin derivative J147 on diabetic peripheral neuropathy (DPN). Methods: We constructed streptozotocin (STZ)-induced DPN rat models to detected mechanical withdrawal threshold (MWT) in vivo using Von Frey filaments. I...
Proteínas Quinasas Activadas por AMP/análisis,
Proteínas Quinasas Activadas por AMP/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Western Blotting,
Calcio/análisis,
Supervivencia Celular/efectos de los fármacos,
Células Cultivadas,
Curcumina/análogos & derivados,
Curcumina/farmacología,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Mellitus Experimental/metabolismo,
Neuropatías Diabéticas/tratamiento farmacológico,
Neuropatías Diabéticas/metabolismo,
Microscopía Fluorescente,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Reproducibilidad de los Resultados,
Estreptozocina,
Canal Catiónico TRPA1/análisis,
Canal Catiónico TRPA1/efectos de los fármacos,
Factores de Tiempo
Abstract Purpose: To investigate the effects of melatonin on antioxidant capacity, inflammation and apoptotic cell death (through expression of cleaved-caspase 3) in lung tissue samples of diabetic rats. Methods: Thirty male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control...
Antioxidantes/farmacología,
Caspasa 3/análisis,
Caspasa 3/efectos de los fármacos,
Catalasa/análisis,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Experimental/patología,
Glutatión/análisis,
Inmunohistoquímica,
Peroxidación de Lípido,
Pulmón/efectos de los fármacos,
Pulmón/metabolismo,
Pulmón/patología,
Malondialdehído/análisis,
Melatonina/farmacología,
Peroxidasa/análisis,
Piroptosis/efectos de los fármacos,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Reproducibilidad de los Resultados,
Estreptozocina,
Superóxido Dismutasa/análisis,
Factores de Tiempo
Abstract Purpose: To investigate the cause of congenital anomalies resulted from gestational diabetes on fetal cardiac tissue in experimental animal study model. Methods: Totally 12 female Wistar albino rats were divided into two groups, each consisting of 6 rats. Streptozotocin (60 mg/kg) was administ...
Antioxidantes/análisis,
Glucemia/análisis,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Gestacional,
Corazón/embriología,
Cardiopatías Congénitas/embriología,
Cardiopatías Congénitas/etiología,
Cardiopatías Congénitas/patología,
Hiperglucemia/complicaciones,
Microscopía,
Miocardio/patología,
Miocitos Cardíacos/patología,
Estrés Oxidativo,
Ratas Wistar,
Valores de Referencia,
Estreptozocina
Abstract Activity of hepatic metabolic enzymes of glucuronidation and sulfation of 4-nitrophenol (PNP) and biliary excretion of its glucuronide (PNP-G) and sulfate (PNP-S) conjugates have been investigated in control and streptozotocin (STZ)-induced diabetic rats. 500 μM PNP solution was luminally perf...
ABSTRACT Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin...
