The mutations are genetic changes in the genome sequences and have a significant role in biotechnology, genetics, and molecular biology even to find out the genome sequences of a cell DNA along with the viral RNA sequencing. The mutations are the alterations in DNA that may be natural or spontaneous and ...
Abstract: Boron is one of the most important micronutrients for plants. Plants may suffer from deficiency or with boron toxicity. Boron plays a role in significant physiological and biochemical events in plants such as synthesis of the cell wall, membrane integrity, antioxidation, transport of photosynth...
Carthamus tinctorius/metabolismo,
Carthamus tinctorius/enzimología,
Boro/administración & dosificación,
Antioxidantes/metabolismo,
Estrés Oxidativo/efectos de los fármacos,
Expresión Génica/efectos de los fármacos,
Boro/toxicidad,
Oligoelementos/administración & dosificación,
Oligoelementos/toxicidad,
Carthamus tinctorius/genética,
24444
Angiotensin-II (AgII) is thought to be crucial for tumor growth and progression. Moreover, hydrogen sulfide (H2S) performs a controversial action in cancer pathology. Zofenopril (ZF) is an angiotensin-converting enzyme (ACE) inhibitor with H2S donating properties. Hence, this study aims at investigating ...
Gomes, Lorena Caixeta;
Resende, Rodrigo Ribeiro;
Parreira, Ricardo Cambraia;
Ferreira, Cláudia Natália;
Reis, Edna Afonso;
Duarte, Rita Carolina Figueiredo;
Alves, Luan Carlos Vieira;
Araújo, Sergio Schusterschitz da Silva;
Carvalho, Maria das Graças;
Sabino, Adriano de Paula.
Abstract The present study evaluated 56 patients diagnosed with Chronic Lymphocytic Leukemia (CLL) and a control group of 44 clinically healthy subjects with no previous history of leukemia. Genetic expressions of AKT and microRNAs were evaluated by quantitative PCR (qPCR). A significant increase in AKT ...
Braga, Tatiane Vieira;
Evangelista, Fernanda Cristina Gontijo;
Santiago, Marie Gabriele;
Ferrão, Aline Lúcia Menezes;
Almeida, Tamara Dauare de;
Barbosa, Bárbara Lima da Fonseca;
Araujo, Sergio Schusterschitz da Silva;
Ribeiro, Glaciano Nogueira;
Carvalho, Maria das Graças;
Sabino, Adriano de Paula.
Chronic lymphocytic leukemia (CLL) is a blood cancer characterized by the accumulation of clonal B-lymphocytes. This study evaluated the mRNA gene expression of miR-15a, miR-16- 1, ZAP-70, and Ang-2 by qPCR, as well as the plasma levels of Bcl-2 by Elisa immunoassay, in CLL patients and healthy controls....
Abstract | Introduction: Broccoli (Brassica oleracea) is well known for its properties as an anticancer, antioxidant, and scavenger of free radicals. However, its benefits in enhancing spermatogenesis have not been well established. Objective: To study broccoli aqueous extract effects on sperm factors a...
Introducción: Para diseñar vacunas es necesario comprender la función de los antígenos de Plasmodium spp. in-volucrados en la invasión a células hospederas. Diferentes investigaciones han generado proteínas recombinantes utilizando sistemas de expresión heterólogos y así han obtenido m...
BACKGROUND: Super-paramagnetic iron oxide nanoparticles (SPION) contain a chemotherapeutic drug and are regarded as a promising technique for improving targeted delivery into cancer cells. RESULTS: In this study, the fabrication of 5-fluorouracil (5-FU) was investigated with loaded Dextran (DEXSPION) usi...
Fluorouracilo/administración & dosificación,
Neoplasias Hepáticas/tratamiento farmacológico,
Carcinoma Hepatocelular/tratamiento farmacológico,
Nanopartículas/administración & dosificación,
Expresión Génica/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Sistemas de Liberación de Medicamentos,
Polímeros,
Nanopartículas de Magnetita,
Preparaciones de Acción Retardada,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Citometría de Flujo
BACKGROUND: Alginates are polysaccharides used in a wide range of industrial applications, with their functional properties depending on their molecular weight. In this study, alginate production and the expression of genes involved in polymerization and depolymerization in batch cultures of Azotobacter ...
