LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Drug resistance in helicobacter pylori

ABSTRACT Background Helicobacter pylori has a worldwide distribution and is associated with the pathogenesis of various diseases of the digestive system. Treatment to eradicate this microorganism involves the use of a combination of antimicrobials, such as amoxicillin, metronidazole, clarithromycin, and...

Molecular detection of clarithromycin and fluoroquinolones resistance in helicobacter pylori infection, directly applied to gastric biopsies, in an urban brazilian population

Martins, Gustavo Miranda; Sanches, Bruno Squárcio Fernandes; Moretzsohn, Luciana Dias; Lima, Karine Sampaio; Cota, Bianca Della Croce V; Coelho, Luiz Gonzaga Vaz.

Arq. gastroenterol; 53 (2), 2016

ABSTRACT Background - Antimicrobial resistance is the major factor leading to eradication failure in H. pylori treatment. Molecular tests are useful to detect genetic mutations predictive of clarithromycin and fluoroquinolones resistance. Knowledge of the local prevalence rate of resistance is importa...

Antibacterianos/farmacología, Antibacterianos/uso terapéutico, Biopsia, Claritromicina/farmacología, Claritromicina/uso terapéutico, Farmacorresistencia Bacteriana, Fluoroquinolonas/farmacología, Fluoroquinolonas/uso terapéutico, Infecciones por Helicobacter/tratamiento farmacológico, Infecciones por Helicobacter/microbiología, Helicobacter pylori/efectos de los fármacos, Helicobacter pylori/genética, Helicobacter pylori/aislamiento & purificación, Persona de Mediana Edad, Mutación/genética, Factores de Riesgo, Población Urbana

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