ABSTRACT Objective: The advent of multikinase inhibitor (MKI) therapy has led to a radical change in the treatment of patients with advanced thyroid carcinoma. The aim of this manuscript is to communicate rare adverse events that occurred in less than 5% of patients in clinical trials in a subset of pat...
Antineoplásicos/efectos adversos,
Carcinoma/tratamiento farmacológico,
Carcinoma Medular/tratamiento farmacológico,
Estudios de Seguimiento,
Insuficiencia Cardíaca/inducido químicamente,
Perforación Intestinal/inducido químicamente,
Estimación de Kaplan-Meier,
Ooforitis/inducido químicamente,
Compuestos de Fenilurea/efectos adversos,
Piperidinas/efectos adversos,
Inhibidores de Proteínas Quinasas/efectos adversos,
Quinazolinas/efectos adversos,
Quinolinas/efectos adversos,
Estudios Retrospectivos,
Factores de Riesgo,
Sorafenib/efectos adversos,
Trombocitopenia/inducido químicamente,
Neoplasias de la Tiroides/tratamiento farmacológico,
Factores de Tiempo
ABSTRACT Objective: To explore the application methods of mitogen-activated protein kinase signal pathway inhibitors SP600125 and SB203580 in long-term in vivo experiments. Methods: A total of 55 healthy New Zealand rabbits were randomly divided into blank control group, model control group, SP low dos...
ABSTRACT Janus kinases inhibitors have already been incorporated into the management of immune-mediated diseases, such as rheumatoid arthritis, and are being investigated for the treatment of psoriasis and inflammatory bowel diseases, both ulcerative colitis and Crohn's disease. Tofacitinib is an oral sm...
Hepner, Adriana;
Salgues, Alessandra;
Anjos, Carlos A. dos;
Sahade, Marina;
Camargo, Veridiana P;
Garicochea, Bernardo;
Shoushtari, Alexander N;
Postow, Michael A;
Fernandes, Gustavo S;
Munhoz, Rodrigo R.
Summary Following decades of relative ostracism, advances in the treatment of melanoma have brought a new reality for patients, physicians and researchers. While antibodies targeting molecules involved in the modulation of the interaction between melanoma and immune cells changed the meaning of the term ...
Resumen: Objetivo: Determinar algunos mecanismos moleculares por los cuales la activación de ROCK cardíaca post infarto del miocardio (IAM) participa en el remodelado y en deterioro de la función sistólica. Métodos: Determinación simultánea de niveles de proteínas blanco de ROCK cardíaca, de f...
Quinasas Asociadas a rho/antagonistas & inhibidores,
Infarto del Miocardio/tratamiento farmacológico,
Función Ventricular Izquierda/efectos de los fármacos,
1-(5-Isoquinolinesulfonil)-2-Metilpiperazina/análogos & derivados,
Remodelación Ventricular/efectos de los fármacos,
Ratas Sprague-Dawley,
1-(5-Isoquinolinesulfonil)-2-Metilpiperazina/farmacología,
Western Blotting,
Tamaño de los Órganos/efectos de los fármacos,
Cardiomegalia/tratamiento farmacológico,
Inhibidores de Proteínas Quinasas/farmacología,
Fosforilación,
Infarto del Miocardio/enzimología,
Modelos Animales de Enfermedad
ABSTRACT Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from parafollicular C cells of the thyroid and associated with mutations in the proto-oncogene REarranged during Transfection (RET). The prognosis of MTC depends on clinical stage, with a 95.6% 10-year survival rate amo...
Anilidas/efectos adversos,
Anilidas/uso terapéutico,
Carcinoma Neuroendocrino/tratamiento farmacológico,
Carcinoma Neuroendocrino/metabolismo,
Piperidinas/efectos adversos,
Piperidinas/uso terapéutico,
Inhibidores de Proteínas Quinasas/efectos adversos,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Piridinas/efectos adversos,
Piridinas/uso terapéutico,
Quinazolinas/efectos adversos,
Quinazolinas/uso terapéutico,
Medición de Riesgo,
Neoplasias de la Tiroides/tratamiento farmacológico,
Neoplasias de la Tiroides/metabolismo
Varghese, Joy;
Kedarisetty, Chandan Kumar;
Venkataraman, Jayanthi;
Srinivasan, Vijaya;
Deepashree, Thiruchunapalli;
Uthappa, Mangerira Chinnappa;
Ilankumaran, Kaliamurthy;
Govil, Sanjay;
Reddy, Mettu Srinivas;
Rela, Mohamed.
ABSTRACT Background & Aim. Transarterial chemoembolization (TACE) or sorafenib is recommended for hepatocellular carcinoma BCLC stages B and C respectively. We studied the role of combination of TACE and sorafenib in BCLC stages B/C. Material and methods. We undertook an observational study on a ...
Antineoplásicos/uso terapéutico,
Carcinoma Hepatocelular/terapia,
Neoplasias Hepáticas/terapia,
Niacinamida/análogos & derivados,
Compuestos de Fenilurea/uso terapéutico,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Antineoplásicos/efectos adversos,
Carcinoma Hepatocelular/etiología,
Carcinoma Hepatocelular/mortalidad,
Carcinoma Hepatocelular/patología,
Quimioembolización Terapéutica/efectos adversos,
Quimioembolización Terapéutica/mortalidad,
Estimación de Kaplan-Meier,
Neoplasias Hepáticas/etiología,
Neoplasias Hepáticas/mortalidad,
Estadificación de Neoplasias,
Niacinamida/efectos adversos,
Niacinamida/uso terapéutico,
Compuestos de Fenilurea/efectos adversos,
Inhibidores de Proteínas Quinasas/efectos adversos,
Factores de Tiempo,
Resultado del Tratamiento,
Carga Tumoral
INTRODUCCIÓN: Antecedentes: El presente dictamen expone la evaluación de tecnología de la eficacia y seguridad tofacitinib en pacientes con artritis reumatoide con falla a tratamiento con anti-TNF y anti-CD20. Aspcetos Generales: La artritis reumatoide (AR) es un tipo de poliatritis periférica de nat...
ABSTRACT Radioiodine (RAI)-refractory thyroid cancer is an uncommon entity, occurring with an estimated incidence of 4-5 cases/year/million people. RAI refractoriness is more frequent in older patients, in those with large metastases, in poorly differentiated thyroid cancer, and in those tumors with high...
