Abstract Introduction: Mucosal leishmaniasis has a progressive course and can cause deformity and even mutilation in the affected areas. It is endemic in the American continent and it is mainly caused by Leishmania (Viannia) braziliensis. Objective: To describe a series of mucosal leishmaniasis cases a...
Leishmania braziliensis/aislamiento & purificación,
Leishmania guyanensis/aislamiento & purificación,
Leishmaniasis Mucocutánea/parasitología,
Colombia/epidemiología,
ADN Protozoario/genética,
Genes Protozoarios,
Proteínas HSP70 de Choque Térmico/genética,
Leishmania braziliensis/clasificación,
Leishmania braziliensis/genética,
Leishmania guyanensis/clasificación,
Leishmania guyanensis/genética,
Leishmaniasis Mucocutánea/complicaciones,
Leishmaniasis Mucocutánea/epidemiología,
Leishmaniasis Mucocutánea/patología,
Reacción en Cadena de la Polimerasa,
Polimorfismo de Longitud del Fragmento de Restricción,
Proteínas Protozoarias/genética,
Análisis de Secuencia de ADN,
Piel/parasitología,
Especificidad de la Especie
Alveolar macrophages (AMs) are an essential part of defense mechanisms within the lungs and their phagocytic activity is important for organ homeostasis. The phagocytic ability of AMs obtained from bronchoalveolar lavage from 17 mature mixed-breed pleasure horses (8 healthy and 9 diagnosed with mild equi...
Abstract: Disseminated leishmaniasis is a severe and emerging form of American tegumentary leishmaniasis. Disseminated leishmaniasis is defined by the presence of more than 10 polymorphic cutaneous lesions, distributed over more than two noncontiguous parts of the body. Nasal mucosal involvement is obser...
BACKGROUND In addition to the limited therapeutic arsenal and the side effects of antileishmanial agents, drug resistance hinders disease control. In Brazil, Leishmania braziliensis causes atypical (AT) tegumentary leishmaniasis lesions, frequently refractory to treatment. OBJECTIVES The main goal of ...
Abstract In Brazil, meglumine antimoniate is the first drug of choice for mucosal leishmaniasis treatment followed by amphotericin B and pentamidine isethionate. We report the case of a patient with severe mucosal lesions caused by Leishmania (Viannia) braziliensis that were difficult to treat. Over a 14...
BACKGROUND Calpains are proteins belonging to the multi-gene family of calcium-dependent cysteine peptidases that undergo tight on/off regulation, and uncontrolled proteolysis of calpains is associated with severe human pathologies. Calpain orthologues are expanded and diversified in the trypanosomatids...
Western Blotting,
Calpaína/efectos de los fármacos,
Calpaína/genética,
Calpaína/metabolismo,
Calpaína/ultraestructura,
Inhibidores de Cisteína Proteinasa/farmacología,
Dipéptidos/farmacología,
Citometría de Flujo,
Regulación de la Expresión Génica,
Genoma de Protozoos/genética,
Inmunohistoquímica,
Leishmania braziliensis/química,
Leishmania braziliensis/genética,
Leishmania braziliensis/metabolismo,
Leishmania braziliensis/ultraestructura,
Macrófagos Peritoneales/metabolismo,
Ratones Endogámicos BALB C,
Microscopía Electrónica de Transmisión,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factores de Virulencia
Leishmania braziliensis is the etiological agent of American mucosal leishmaniasis, one of the most severe clinical forms of leishmaniasis. Here, we report the assembly of the L. braziliensis (M2904) genome into 35 continuous chromosomes. Also, the annotation of 8395 genes is provided. The public availab...
BACKGROUND Topical treatment of New World cutaneous leishmaniasis can be affected by bacterial coinfection, hyperkeratosis, and transdermal drug delivery. OBJECTIVE The aim of this work was to evaluate the therapeutic response and safety of the topical, sequential use of antiseptic, keratolytic, and p...
BACKGROUND Nicotinamide adenine dinucleotide (NAD) plays a central role in energy metabolism and integrates cellular metabolism with signalling and gene expression. NAD biosynthesis depends on the enzyme nicotinamide/nicotinate mononucleotide adenylyltransferase (NMNAT; EC: 2.7.7.1/18), in which converg...
Resumen Introducción: La diversidad de las formas clínicas de la leishmaniasis del Nuevo Mundo (desde formas cutáneas localizadas a diseminadas o formas mucosas) causada por especies del subgénero Viannia podría inferir en la eficacia de los tratamientos tópicos. El objetivo del presente trabajo f...
