Abstract: Background: Leprosy is a chronic infectious disease that is endemic in Brazil and little studied in patients over 60 years old. Objective: The aim of this study was the epidemiological and clinical description of cases of leprosy in individuals older than 60 years, notified in the State of Es...
Abstract: Leprosy patients can present reactions during the course of the disease. There are no official data on these reactions in Brazil. We aimed to describe the epidemiological characteristics of patients with such reactions, analyzing information from patient records at a referral center in Campinas...
Leprosy is a contagious, chronic infectious disease caused by Mycobacterium leprae. The immune response of the host to this bacillus is variable, determining different clinical forms of the same disease. Between the Lepromatous and Tuberculoid spectra, both stable clinical forms, the Dimorfo type can be ...
Abstract: Background: Erythema nodosum leprosum may appear before, during or after treatment of leprosy and is one of the main factors for nerve damage in patients. When it occurs or continues to occur after treatment, it may indicate disease recurrence and a new treatment may be instituted again. Obje...
Eritema Nudoso/tratamiento farmacológico,
Eritema Nudoso/microbiología,
Leprostáticos/uso terapéutico,
Lepra Lepromatosa/tratamiento farmacológico,
Lepra Lepromatosa/microbiología,
Lepra Multibacilar/tratamiento farmacológico,
Lepra Multibacilar/microbiología,
Neuritis/tratamiento farmacológico,
Neuritis/microbiología,
Recurrencia,
Retratamiento,
Factores de Tiempo,
Resultado del Tratamiento
Abstract INTRODUCTION Corticosteroids and/or thalidomides have been associated with thromboembolism events (TBE) in multibacillary (MB) leprosy. This report aimed to determine genetic and laboratory profiles associated with leprosy and TBE. METHODS Antiphospholipid antibodies (aPL), coagulation-relat...
Corticoesteroides/administración & dosificación,
Corticoesteroides/efectos adversos,
Anticuerpos Antifosfolípidos/sangre,
Anticuerpos Antifosfolípidos/efectos de los fármacos,
Anticuerpos Antifosfolípidos/genética,
Síndrome Antifosfolípido/sangre,
Síndrome Antifosfolípido/tratamiento farmacológico,
Síndrome Antifosfolípido/genética,
Ensayo de Inmunoadsorción Enzimática,
Factor V/análisis,
Inmunoglobulina G/sangre,
Inmunoglobulina M/sangre,
Lepra Multibacilar/tratamiento farmacológico,
Lepra Multibacilar/genética,
Lepra Multibacilar/inmunología,
Persona de Mediana Edad,
Mutación,
Polimorfismo Genético,
Protrombina/análisis,
Talidomida/administración & dosificación,
Talidomida/efectos adversos,
Tromboembolia Venosa/tratamiento farmacológico,
beta 2 Glicoproteína I/sangre
BACKGROUND Leprosy remains a health problem in many countries, with difficulties in diagnosis resulting in delayed treatment and more severe disabilities. Antibodies against several Mycobacterium leprae antigens have, however, shown value as diagnostic and/or prognostic markers. OBJECTIVES The objecti...
Resumo: O projeto Palmas Livre da Hanseníase foi implementado para o incremento dos indicadores e o enfrentamento da doença, visto que a capital do Tocantins é a mais hiperendêmica do país. Este estudo mede o impacto da intervenção do projeto por meio da análise da tendência de indicadores prior...
Brasil/epidemiología,
Enfermedades Endémicas,
Sistemas de Información en Salud,
Personal de Salud/educación,
Incidencia,
Lepra Multibacilar/epidemiología,
Lepra Multibacilar/prevención & control,
Lepra Paucibacilar/epidemiología,
Lepra Paucibacilar/prevención & control,
Prevalencia,
Atención Primaria de Salud/estadística & datos numéricos,
Evaluación de Programas y Proyectos de Salud,
Valores de Referencia,
Análisis de Regresión,
Índice de Severidad de la Enfermedad,
Factores de Tiempo
Introdução: Diversos fatores podem interferir no desenvolvimento da hanseníase, entre eles fatores genéticos, convívio com o caso de hanseníase e classificação operacional do caso. Testes sorológicos que avaliam a reatividade de anticorpos IgM e IgG frente a antígenos específicos para o Mycoba...
Abstract Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4-16 years old, wh...
Anticuerpos Antibacterianos/administración & dosificación,
Antígenos Bacterianos/análisis,
Antígenos Bacterianos/inmunología,
Trazado de Contacto,
Ensayo de Inmunoadsorción Enzimática,
Familia,
Glucolípidos/análisis,
Glucolípidos/inmunología,
Lepra Multibacilar/diagnóstico,
Lepra Paucibacilar/diagnóstico,
Mycobacterium leprae/inmunología,
Saliva/química,
Saliva/inmunología
Abstract Wade's histoid leprosy (HL) is a rare variant of multibacillary leprosy, with characteristic clinical, immunologic, histopathologic, and bacteriologic features. It is associated with resistance to sulfa drugs or polychemotherapy and is rarely observed in patients who have not undergone prior tre...
