Burin, Sandra Mara;
Cacemiro, Maira da Costa;
Cominal, Juçara Gastaldi;
Grandis, Rone Aparecido De;
Machado, Ana Rita Thomazela;
Donaires, Flavia Sacilotto;
Cintra, Adelia Cristina Oliveira;
Ambrosio, Luciana;
Antunes, Lusânia Maria Greggi;
Sampaio, Suely Vilela;
Castro, Fabíola Attié de.
Resistance to apoptosis in chronic myeloid leukemia (CML) is associated with constitutive tyrosine kinase activity of the Bcr-Abl oncoprotein. The deregulated expression of apoptosis-related genes and alteration in epigenetic machinery may also contribute to apoptosis resistance in CML. Tyrosine kinase i...
Moura, Muriel Silva;
Benevides, Thais Celi Lopes;
Delamain, Marcia Torresan;
Duarte, Gislaine Oliveira;
Percout, Priscila Oliveira;
Dias, Maria Almeida;
Zulli, Roberto;
Souza, Carmino Antonio de;
Lorand-Metze, Irene;
Pagnano, Katia Borgia Barbosa.
ABSTRACT Introduction: The incidence of grade 3-4 anemia was reported to be 3% with imatinib therapy for newly diagnosed chronic myeloid leukemia (CML) in the chronic phase (CP). However, there are few data regarding the causes and the development of anemia after long-term treatment. This study aimed to...
ABSTRACT Background: The establishment of regional development poles in the State of Pernambuco, Brazil was characterized by industrial expansion and consequent concerns about the increase in the occurrence of diseases, specifically those having long latency periods, as is the case of Chronic Myeloid Le...
Bosi, Guilherme Rasia;
Fogliatto, Laura Maria;
Costa, Tito Emilio Vanelli;
Grokoski, Kamila Castro;
Pereira, Mariana Pinto;
Bugs, Nathan;
Kalil, Marco;
Fraga, Christina;
Daudt, Liane Esteves;
Silla, Lucia Mariano da Rocha.
ABSTRACT Objective: To assess clinical outcomes of intolerant, relapsed or refractory patients who could not be treated with new tyrosine kinase inhibitors or experimental therapies. Methods: A retrospective cohort of 90 chronic myeloid leukemia patients in all phases of the disease treated with imatin...
ABSTRACT We analyzed the management and outcomes of pregnancies of patients with chronic myeloid leukemia at a single center over fifteen years. Among the 203 CML female patients, there were ten pregnancies in seven women, all of them not planned. In three cases, the chronic myeloid leukemia diagnosis wa...
ABSTRACT Introduction and objective: In this study, we evaluated the influence of the transcript type on hematological and clinical parameters, as well as the event-free survival of 50 patients in the Chronic myeloid leukemia chronic phase. Methods: We reviewed the medical records of 55 patients with C...
ABSTRACT Background: There has been a revolution in the treatment of Chronic Myeloid Leukemia since imatinib's introduction. However, patient adherence has a great impact on the response obtained with medical treatment. This study's objective was to analyze the drug adherence and the factors that influe...
As mutações que ocorrem no gene GATA2 podem ocasionar um amplo espectro de doenças genéticas. Os pacientes podem ter anormalidades na hematopoiese, na linfangiogenesis e na resposta imunológica. Os fenótipos incluem algumas síndromes caracterizadas por monocitopenia e infecção por micobactéria ...
Deficiencia GATA2,
Enfermedades Genéticas Congénitas,
Síndromes Mielodisplásicos,
Pacientes,
Linfangiogénesis,
Hematopoyesis,
Leucemia Mieloide Aguda,
Leucemia Mielógena Crónica BCR-ABL Positiva,
Linfedema,
Mutación,
Neutropenia
Resumen Se presentan dos casos clínicos de pacientes con leucemia mieloide crónica en fase acelerada, hospitalizados para inicio de terapia dirigida con inhibidores de tirosina cinasa (dasatinib). Posteriormente se determina la presencia de sangrado intraparenquimatoso a sistema nervioso central. Para ...
