Results: 127

Ferulic acid improves motor function induced by spinal cord injury in rats via inhibiting neuroinflammation and apoptosis

Acta cir. bras; 36 (7), 2021
ABSTRACT Purpose To investigate the effect of ferulic acid (FA) on spinal cord injury (SCI)-induced motor dysfunction and to explore the possible pharmacological mechanisms. Methods Adult male Wistar rats were used in our study. SCI was achieved by clipping the spinal cord T9 of the rat by a vascular c...

The effect of mild hypothermia plus rutin on the treatment of spinal cord injury and inflammatory factors by repressing TGF-β/smad pathway

Acta cir. bras; 36 (3), 2021
ABSTRACT Purpose To probe the mechanism of mild hypothermia combined with rutin in the treatment of spinal cord injury (SCI). Methods Thirty rats were randomized into the following groups: control, sham, model, mild hypothermia (MH), and mild hypothermia plus rutin (MH+Rutin). We used modified Allen's ...

Effects of vitamin D administration on nociception and spinal cord pro-oxidant and antioxidant markers in a rat model of neuropathic pain

Braz. j. med. biol. res; 54 (10), 2021
Reactive oxygen species (ROS) are involved in neuropathic pain, a complicated condition after nerve tissue lesion. Vitamin D appears to improve symptoms of pain and exhibits antioxidant properties. We investigated the effects of oral administration of vitamin D3, the active form of vitamin D, on nocicept...

Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases

Braz. j. med. biol. res; 54 (10), 2021
The etiology of subacute combined degeneration (SCD) of the spinal cord is closely associated with vitamin B12 (VitB12) deficiency. The clinical manifestations of SCD are complex and vary substantially. Due to some SCD patients with atypical manifestations and concomitant autoimmune disorders, the probab...

Produção científica dos cuidados de enfermagem ao paciente com traumatismo da medula espinhal: uma análise bibliométrica

Objetivo: Descrever a distribuição da produção científica dos cuidados de enfermagem ao paciente com traumatismo da medula espinhal e verificar quais as temáticas mais abordadas. Método: Análise bibliométrica através da Lei de Bradford, Lei de Zipf e estatística textual realizada com publica...

Standardization of an experimental model of intradural injection after spinal cord injury in rats

Clinics; 76 (), 2021
OBJECTIVES: The intrathecal route has not yet been thoroughly standardized and evaluated in an experimental model of spinal cord injury (SCI) in Wistar rats. The objective of this study was to standardize and evaluate the effect of intradural injection in this animal model. METHOD: The animals were divi...

Absceso epidural posterolateral y compresión radicular: una rara complicación del absceso retrofaríngeo

Introducción: el absceso epidural posterolateral y la compresión radicular es una rara complicación del absceso retrofaríngeo (ARF). Se realizó el reporte de un caso con esta complicación extremadamente rara. Método: reporte de caso y revisión de la literatura (estudios radiológicos, historia y ...

Neuromielitis óptica: reporte de un caso clínico

Más Vita; 2 (4), 2020
La neuromielitis óptica (NMO) y los trastornos del espectro de neuromielitis óptica (NMOSD) son trastornos poco frecuentes, mediados por anticuerpos del sistema nervioso central (SNC) con predilección por la médula espinal y los nervios ópticos. Existe una fuerte predilección femenina. En el caso d...

Autophagy activation attenuates the neurotoxicity of local anesthetics by decreasing caspase-3 activity in rats

Rev. bras. anestesiol; 70 (6), 2020
Abstract Background and objectives The mechanisms by which local anesthetics cause neurotoxicity are very complicated. Apoptosis and autophagy are highly coordinated mechanisms that maintain cellular homeostasis against stress. Studies have shown that autophagy activation serves as a protective mechanis...