Scorpion venom is a Chinese medicine for epilepsy treatment, but the underlying mechanism is not clear. Scorpion venom heat-resistant peptide (SVHRP), a peptide isolated from the venom of Buthus martensii Karsch, has an anti-epileptic effect by reducing seizure behavior according to a modified Racine sca...
This study aimed to explore the effect of microRNA (miR)-146a inhibition on regulating cell apoptosis, total neurite outgrowth, inflammation, and STAT1/MYC pathway in Alzheimer's disease (AD). PC12 and cortical neuron cellular AD models were constructed by Aβ1-42 insult. For the former model, nerve ...
Abstract Background and objectives The mechanisms by which local anesthetics cause neurotoxicity are very complicated. Apoptosis and autophagy are highly coordinated mechanisms that maintain cellular homeostasis against stress. Studies have shown that autophagy activation serves as a protective mechanis...
Anestésicos Locales/toxicidad,
Apoptosis/efectos de los fármacos,
Autofagia/efectos de los fármacos,
Autofagia/fisiología,
Beclina-1/metabolismo,
Bupivacaína/administración & dosificación,
Bupivacaína/toxicidad,
Caspasa 3/metabolismo,
Etiquetado Corte-Fin in Situ,
Proteínas Asociadas a Microtúbulos/metabolismo,
Neuronas/efectos de los fármacos,
Neuronas/patología,
Síndromes de Neurotoxicidad/prevención & control,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Sirolimus/administración & dosificación,
Médula Espinal/efectos de los fármacos
SUMMARY: The vomeronasal organ (VNO) is an accessory organ involved on the olfactory pathway, that detects pheromones and emits signals in order to modulate social and reproductive behavior. The VNO stem cells replace neurons throughout life. The aim of this study was to isolate and characterize cells de...
La Parálisis Cerebral (PC) es un conjunto de alteraciones motrices no progresivas en la población infantojuvenil, ocasionadas por lesión –a nivel cerebral- de neuronas o fibras de esa vía, de sus aferencias o de las que la modulan; para su diagnóstico deben conocerse otras patologías también fre...
There are no studies that characterize the enteric nervous system (ENS) bats. The organization and density of myenteric neurons may vary according to the animal species, as well as the segment of the digestive tube considered. The nitric oxide is one of the key neurotransmitters present in the myenteric ...
Resumen Introducción: Este artículo presenta avances de la medicina regenerativa y la ingeniería de tejidos orientados a la regeneración de neuronas, de axones y nervios. Revisamos las técnicas que existen actualmente, las más utilizas o prometedoras, en la búsqueda de avances para regenerar este...
Abstract In live organisms, there is a balance between the production of reactive oxygen species (ROS) and their neutralization. The increased level of these species leads to a condition called redox imbalance. The aim of this study was to evaluate the protective action of isobenzofuranones in primary cu...
BACKGROUND Behavioral and neurochemical alterations associated with toxoplasmosis may be influenced by the persistence of tissue cysts and activation of an immune response in the brain of Toxoplasma gondii-infected hosts. The cerebral extracellular matrix is organised as perineuronal nets (PNNs) that ar...
Cerebelo/citología,
Cerebelo/metabolismo,
Modelos Animales de Enfermedad,
Matriz Extracelular/metabolismo,
Neuronas Motoras/citología,
Neuronas Motoras/metabolismo,
Neuronas/metabolismo,
Neuronas/patología,
Toxoplasma,
Toxoplasmosis/metabolismo,
Toxoplasmosis/patología,
Toxoplasmosis Animal
Pathophysiological mechanisms involved in orofacial pain and their relationship with emotional disorders have emerged as an important research area for multidisciplinary studies. In particular, temporomandibular disorders (TMD) have been evaluated clinically from both physiological and psychological pers...
