Polymorphisms with variable number of tandem repeats (VNTR), are genetic markers used in areas of genomics as evolutionary, epidemiological and population genetics studies. The growth of genomic sequences in data banks and the development of computational tools for bioinformatics allow the mining of thes...
Abstract BACKGROUND: Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. The most accepted mechanism in the etiopathogenesis of psoriasis is the induction of inflammation with keratinocyte hyperproliferation. Granuly...
ABSTRACT Objective: To investigate the correlations between polymorphisms at position 49 in exon 1 and position 318 in the promoter of the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene and autoimmune thyroid diseases in a Han Chinese population. Methods: Polymerase chain reaction-restrictio...
Abstract Objective To evaluate the C-1562T matrix metalloproteinase 9 (MMP9) gene polymorphisms as risk factors related to the occurrence of pelvic organ prolapse (POP) and to identifytheclinicalvariablesassociatedwith theoccurrenceof thedisease.Epidemiological studies of risk factors for POP do not ex...
Distribución por Edad,
Estudios de Casos y Controles,
Predisposición Genética a la Enfermedad/genética,
Genotipo,
Parto Domiciliario,
Metaloproteinasa 9 de la Matriz/genética,
Persona de Mediana Edad,
Paridad,
Prolapso de Órgano Pélvico/genética,
Polimorfismo Genético/genética,
Factores de Riesgo
Abstract INTRODUCTION: Chagas disease (CD) is an important public health problem in Brazil and worldwide. Aging and obesity are important matters in patients with CD, as is hypovitaminosis D3, which can decrease the quality of life of these patients. Immunomodulation mediated by vitamin D3, especially ...
Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed to investigate the effects of ADAMTS5 gene polymorphisms on OA risk in a Chinese population. A total of 300 OA patients and 300 controls were re...
ABSTRACT Objective To evaluate the prevalence of G6PD deficiency and characterize G202A, A376G and C563T polymorphisms in neonates using molecular assays. Methods A total of one thousand samples were tested through quantitative analysis of enzyme activity, detecting 25 G6PD-deficient individuals. Patie...
ABSTRACT Objective To described the allele and haplotype frequencies of human leukocyte antigen genes at the -A, -B loci and human platelet antigen genes for human platelet antigen systems 1 to 9, 11 and 15 in blood. Methods We included 867 healthy unrelated volunteer donors who donated platelets bet...
Ozgen, Merih;
Cosan, Didem Turgut;
Doganer, Fulya;
Soyocak, Ahu;
Armagan, Onur;
Kuzgun, Selen;
Aydogan, Ayse Merve;
Gunes, Hasan Veysi;
Degirmenci, Irfan;
Mutlu, Fezan.
OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isola...
Densidad Ósea,
Frecuencia de los Genes/genética,
Estudios de Asociación Genética,
Osteoporosis Posmenopáusica/genética,
Fracturas Osteoporóticas/genética,
Proyectos Piloto,
Polimorfismo Genético/genética,
Estudios Retrospectivos,
Fracturas de la Columna Vertebral/genética,
Turquía,
Vitamina K Epóxido Reductasas/genética
The aim of this study was to perform an updated meta-analysis to quantitatively investigate the association between G20210A polymorphism of Prothrombin gene and the risk of retinal vein occlusion (RVO), based on the available publications with inconsistent results. We utilized the Stata software to perfo...
