There is emerging evidence for a dysregulation of insulin signaling in the brains of patients with Alzheimer's disease (AD) with overlapping molecular features to Type 2 Diabetes Mellitus (T2DM). In addition, T2DM is a known risk factor of AD. The goal of this study was to investigate the neurogenic and ...
INTRODUCTION: Increasing evidence suggests that changes in the balance of excitatory/inhibitory neurotransmission are involved in the development of the majority of chronic pain forms. In this context, impairment in glycine mediated inhibitory neurotransmission is thought to play a critical role in the d...
Villarreal-Julio, Rafael;
Murillo, Enderson;
Ramírez-Garcia, Rene;
Peláez-Sanchez, Ronald;
López, Juan Álvaro;
Ruiz-López, Freddy;
Agudelo, Luz Adriana;
Vélez, Iván Darío;
-López, Carlos Muskus;
Agudelo-Flórez, Piedad.
Se describe por primera vez una serie de nueve casos con clínica indicativa de leptospirosis en el municipio Puerto Nariño en el departamento Amazonas, Colombia. Se muestran evidencias serológicas de exposición con Rickettsia del grupo de las fiebres manchadas. Los casos fueron clínicamente consider...
V617F mutation in exon 14 of Janus Kinase 2 gene (jak-2) is used as a molecular marker for the diagnosis of Philadelphia negative myeloproliferative neoplasms (Phi-) such as Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (MFP). To detect this mutation, we ...
ABSTRACT GeneXpert is one of the recent technological instruments used to diagnose tuberculosis in a short span of time. In this study, the performance of GeneXpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis (EPTB) was compared with light-emitting diode Fluorescent Microscopy (LED-FM)...
Martínez Muné, María Karla;
Piñón Ramos, Alexander;
Acosta Herrera, Belsy;
Valdés Ramírez, Odalys;
Muné Jiménez, Mayra;
Savón Valdés, Clara;
Arencibia García, Amely;
González Báez, Guelsys;
González Muñoz, Grehete;
Oropesa Fernández, Suset;
Goyenechea Hernández, Ángel;
Hernández Fernández, Bárbara;
Roque Orieta, Rosmery;
Martínez Alonso, Javier.
Las infecciones respiratorias agudas constituyen la causa fundamental de mortalidad y morbilidad en el ámbito mundial. Los principales agentes causales de estas infecciones son los virus. La detección rápida y eficaz de estos patógenos es determinante en el tratamiento y la prevención de las enferme...
Andrade, Elisabete;
Rocha, Daniele;
Fontana-Maurell, Marcela;
Costa, Elaine;
Ribeiro, Marisa;
de Godoy, Daniela Tupy;
Ferreira, Antonio G P;
Tanuri, Amilcar;
Alvarez, Patrícia;
Brindeiro, Rodrigo.
ABSTRACT The Brazilian Public Health Service provides freely αPEG-IFN to treat patients infected with HCV. The primary goal of HCV therapy is the long-term elimination of HCV from the blood to reduce the risk of HCV associated complications and death. Patient viremia affects the treatment duration a...
Antivirales/uso terapéutico,
Brasil,
Genotipo,
Técnicas de Genotipaje,
Hepacivirus/genética,
Hepacivirus/aislamiento & purificación,
Hepatitis C/sangre,
Hepatitis C/tratamiento farmacológico,
Hepatitis C/virología,
Interferón-alfa/uso terapéutico,
Polietilenglicoles/uso terapéutico,
Estudios Prospectivos,
ARN Viral/sangre,
ARN Viral/genética,
ARN Viral/aislamiento & purificación,
Reacción en Cadena en Tiempo Real de la Polimerasa/métodos,
Proteínas Recombinantes/uso terapéutico,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Carga Viral/métodos,
Viremia
Abstract A modified TaqMan real-time polymerase chain reaction targeting a 138 bp fragment within the lipl32 gene was developed to identify exclusively pathogenic Leptospira spp. in dog urine samples. Thirty-five samples from dogs with suspected clinical leptospirosis and 116 samples from apparently heal...
Proteínas de la Membrana Bacteriana Externa/genética,
Proteínas de la Membrana Bacteriana Externa/orina,
Enfermedades de los Perros/diagnóstico,
Enfermedades de los Perros/orina,
Leptospira/genética,
Leptospira/aislamiento & purificación,
Leptospirosis/diagnóstico,
Leptospirosis/microbiología,
Leptospirosis/orina,
Leptospirosis/veterinaria,
Lipoproteínas/genética,
Lipoproteínas/orina,
Reacción en Cadena en Tiempo Real de la Polimerasa/métodos,
Sensibilidad y Especificidad,
Orina/microbiología
Abstract INTRODUCTION: Strongyloides stercoralis is an intestinal parasitic nematode that causes hyperinfection and/or a dissemination syndrome in hosts, which is often difficult to diagnose. This study aims to compare the diagnostic efficacy of four conventional methods used to diagnose strongyloidiasi...
Abstract Detection of Salmonella is very important to minimize the food safety risk. In this study, the recombinant PagC protein and PagC antibody were prepared and coupled with immunomagnetic beads (IMBs) to capture Salmonella cells from pork and milk samples. And then the SYBR Green qualitative PCR was...
Anticuerpos Antibacterianos/inmunología,
Anticuerpos Antibacterianos/metabolismo,
Proteínas Bacterianas/inmunología,
Contaminación de Alimentos,
Microbiología de Alimentos/métodos,
Separación Inmunomagnética/métodos,
Carne/microbiología,
Leche/microbiología,
Reacción en Cadena en Tiempo Real de la Polimerasa/métodos,
Salmonella/genética,
Salmonella/aislamiento & purificación,
Sensibilidad y Especificidad
