Obatoclax reduces cell viability of acute myeloid leukemia cell lines independently of their sensitivity to venetoclax
Hematol., Transfus. Cell Ther. (Impr.); 44 (1), 2022
Results: 243
Application of CRISPR-Cas9 to interrogate novel gene functions in cutaneous melanoma
Melanoma accounts for 3% of skin neoplasms and is the leading cause of death from skin disorders worldwide. The high mortality rate associated with this disease stems from the high capacity of melanoma patients to develop metastases and treatment relapse with inhibitors of the MAPK signaling pathway (suc...
Melanoma/patología, Neoplasias Cutáneas/complicaciones, Piel, Absentismo, Análisis de Secuencia de ARN/instrumentación, Biología Computacional/métodos, Biomarcadores/análisis, Expresión Génica, Metodología como un Tema, Metástasis de la Neoplasia, Neoplasias, Pacientes/clasificación, Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas, Supervivencia Celular, Técnicas In Vitro/métodos
Citotoxicidad in vitro del polipéptido antimicrobiano nisina sobre células tumorales sanguíneas
Int. j. morphol; 40 (5), 2022
RESUMEN: Las bacteriocinas son péptidos antimicrobianos de síntesis ribosomal secretadas por bacterias. Dentro de estas destaca nisina que posee potenciales usos en terapias antibióticas, como biopreservante de alimentos y probióticos. También se ha descrito que nisina posee citotoxicidad sobre lín...
Nisina/farmacología, Antibacterianos/farmacología, Bacteriocinas/farmacología, Línea Celular Tumoral/efectos de los fármacos, Técnicas In Vitro, Supervivencia Celular/efectos de los fármacos, Células K562/efectos de los fármacos, Células U937/efectos de los fármacos, Staphylococcus aureus/efectos de los fármacos, Pruebas de Sensibilidad Microbiana
Cytotoxicity Comparison of a Calcium Silicate-Based Resin Cement versus Conventional Self-Adhesive Resin Cement and a Resin-Modified Glass Ionomer: Cell Viability Analysis
Pesqui. bras. odontopediatria clín. integr; 22 (), 2022
Abstract Objective: To compare the cytotoxicity level of a new calcium silicate-based resin cement (TheraCem) with two commonly used cements, including a conventional self-adhesive resin cement (Panavia SA) and a resinmodified glass ionomer cement (FujiCem2), on the human gingival fibroblast cells after...
Ação antimicrobiana e antibiofilme de flavonóis isolados ou incorporados em hidrogéis termossensíveis e sua influência sobre marcadores de mineralização em células odontoblastóides para aplicação em endodontia
Ainda não foi encontrado um medicamento capaz de desinfetar os canais radiculares e permitir a recuperação celular e a regeneração tecidual em dentes permanentes jovens com comprometimento endodôntico. Dois importantes flavonóis detectados no vinho tinto, morina (MO) e miricetina (MY), são atualm...
Sideritis perfoliata inhibits cell proliferation, induces apoptosis and exhibits cellular antioxidant activity in cervical cancer cells
Bol. latinoam. Caribe plantas med. aromát; 20 (4), 2021
In this study, it was aimed to determine the antioxidant and anticancer activities of Sideritis perfoliata methanolic extract (SPE) on cervical cancer cells (HeLa). Different doses (25, 50,100 and 200 μg/mL) of SPE were used to determine proliferation of HeLa cells by 3-[4,5-dimethylthiazol-2-yl]-2,5-di...
Neoplasias del Cuello Uterino, Sideritis/química, Proliferación Celular/efectos de los fármacos, Apoptosis/efectos de los fármacos, Antioxidantes/administración & dosificación, Extractos Vegetales/administración & dosificación, Antineoplásicos, Interleucina-8/análisis, Interleucina-6/análisis, Extractos Vegetales/química, Antioxidantes/química, Fenoles/análisis, Supervivencia Celular, Cromatografía de Gases y Espectrometría de Masas
Morphological and biochemical effects of carnosic acid on human hepatocellular carcinoma HepG2 cells
Int. j. med. surg. sci. (Print); 8 (2), 2021
Background/aim: Autophagic cell death and apoptosis of tumor cells has become one of the main objectives in cancer treatment, whereas tumor cell lines are mainly used in studies for providing important data for the evaluation of potential anti cancer substances. In this study, our objecti...
Cinamaldeído e terpineol como inibidores de biofilmes de Candida albicans e Enterococcus faecalis
Cinnamaldehyde and terpineol as inhibitors of Candida albicans and Enterococcus faecalis biofilms
Rev. cuba. estomatol; 58 (2), 2021
Introdução: Os fitoconstituintes são moléculas naturais que apresentam atividade antimicrobiana satisfatória e devem ser estudados quanto ao seu uso como novas substâncias para irrigação dos canais radiculares. Objetivo: Avaliar o efeito inibitório dos fitoconstituintes cinamaldeído e α-ter...
Effectiveness of different methods for the extraction of principle actives and phytochemicals content in medicinal herbals
Bol. latinoam. Caribe plantas med. aromát; 20 (3), 2021
In this present study, we investigated the influence of various extraction methods including maceration, sonication, infusion, decoction, and microwave extraction, on the chemical and biological potential of phytochemicals extracted from three medicinal plants (Ageratum conyzoides, Plantago majorand Arc...
Establishment of a production process for a novel vaccine candidate against Lawsonia intracellularis
Electron. j. biotechnol; 50 (), 2021
BACKGROUND: Lawsonia intracellularis remains a problem for the swine industry worldwide. Previously, we designed and obtained a vaccine candidate against this pathogen based on the chimeric proteins: OMP1c, OMP2c, and INVASc. These proteins formed inclusion bodies when expressed in E. coli, which induced...
Lawsonia (Bacteria)/inmunología, Infecciones por Desulfovibrionaceae/prevención & control, Vacunas Bacterianas/inmunología, Vacunas Bacterianas/administración & dosificación, Vacunación, Inmunidad, Técnicas de Cultivo Celular por Lotes, Fermentación, Vacunas Sintéticas, Enfermedades de los Porcinos/inmunología, Enfermedades de los Porcinos/prevención & control, Porcinos, Supervivencia Celular