Background The use of narrow therapeutic index generic immunosuppressant in solid organ transplantation is controversial. Most experiences switching to these drugs have short term follow-up periods, analyze only pharmacokinetic issues and do not systematically include either complications or cost analys...
OBJECTIVES: Here, we aimed to compare the clinical effects of mycophenolate mofetil combined with either tacrolimus or with cyclophosphamide on lupus nephritis (LN) and to analyze their influence on the expression of cystatin C and on transforming growth factor-1 (TGF-β1). METHODS: A total of 234 p...
RESUMO Os polimorfismos genéticos do CYP3A5 têm sido apontados enquanto fatores influenciadores na eficácia farmacológica com tacrolimo em pacientes em terapia imunossupressora no pós-transplante hepático. O presente estudo objetiva realizar uma revisão da literatura acerca da influência dos poli...
Introducción. El desarrollo de terapias inmunosupresoras en trasplante hepático ha sido uno de los aspectos fundamentales que ha permitido disminuir la presencia de rechazos y mejorar la supervivencia del injerto y de los pacientes. El presente estudio se hizo para conocer la efectividad de dos esquem...
ABSTRACT Background: Tacrolimus and mycophenolate mofetil are immunosuppressive agents widely used on the postoperative period of the transplants. Aim: To evaluate the influence of the association of them on the abdominal wall healing in rats. Methods: Thirty-six Wistar rats were randomly assigned ...
Pared Abdominal/cirugía,
Inmunosupresores/farmacología,
Isquemia,
Riñón/irrigación sanguínea,
Ácido Micofenólico/administración & dosificación,
Ácido Micofenólico/farmacología,
Ratas Wistar,
Reperfusión,
Daño por Reperfusión/complicaciones,
Tacrolimus/administración & dosificación,
Tacrolimus/farmacología
This work is aimed at studying the problems of timely diagnostics and therapy of various forms of rosacea, identifying the factors that influence the compliance, prognosis, and quality of life of the patients, as well as the stages of combination therapy. The efficiency of rosacea therapy is determined b...
Abstract BACKGROUND: Tacrolimus, for its activity on modulation of collagen production and fibroblast activity, may have a role in the prevention of hypertrophic scars. OBJECTIVES: Evaluate macroscopic, microscopic, metabolic, laboratory effects and side effects of the use of topical tacrolimus ointmen...
Administración Tópica,
Alanina Transaminasa/sangre,
Alanina Transaminasa/efectos de los fármacos,
Inhibidores de la Calcineurina/administración & dosificación,
Inhibidores de la Calcineurina/farmacología,
Inhibidores de la Calcineurina/uso terapéutico,
Cicatriz Hipertrófica/patología,
Cicatriz Hipertrófica/prevención & control,
Creatinina/sangre,
Modelos Animales de Enfermedad,
Oído Externo/patología,
Eritema/patología,
Inflamación/patología,
Inflamación/prevención & control,
Recuento de Linfocitos,
Pomadas,
Albúmina Sérica/análisis,
Albúmina Sérica/efectos de los fármacos,
Tacrolimus/administración & dosificación,
Tacrolimus/farmacología,
Tacrolimus/uso terapéutico,
Urea/sangre
ABSTRACT Purpose: To assess the compliance, efficacy, and safety of the long-term use of topical tacrolimus for the clinical management of vernal keratoconjunctivitis. Methods: The medical records of patients with vernal keratoconjunctivitis undergoing long-term treatment with 0.03% topical tacrolimus ...
Administración Oftálmica,
Corticoesteroides/uso terapéutico,
Conjuntivitis Alérgica/tratamiento farmacológico,
Inmunosupresores/administración & dosificación,
Cumplimiento de la Medicación,
Pomadas/administración & dosificación,
Reproducibilidad de los Resultados,
Estudios Retrospectivos,
Tacrolimus/administración & dosificación,
Factores de Tiempo,
Resultado del Tratamiento
The intent of the present investigation is to develop and evaluate colon-specific coated tacrolimus solid dispersion pellet (SDP) that retards drug release in the stomach and small intestine but progressively releases in the colon. Tacrolimus-SDP was prepared by extrusion-spheronization technology and op...
