Results: 44

Governança global, regulamentação flexível e os ensaios clínicos na medicina regenerativa no Reino Unido e na União Europeia

Physis (Rio J.); 30 (4), 2020
Resumo A medicina regenerativa encontra-se em fase de desenvolvimento dos ensaios clínicos em terapias celulares (TC), na sua manufatura e na sua adoção gradual dentro dos sistemas de saúde. Entretanto, há uma série de lacunas e contradições na governança e regulamentação na área e o objetivo...

Isolamento e diferenciação das células-tronco da polpa dentária canina em células progenitoras neurais

O objetivo deste estudo foi verificar a capacidade de diferenciação das células-tronco da polpa dentária canina em células progenitoras neurais bem como quantificar obtenção e viabilidade celular, durante três passagens em cultura. As células foram extraídas da polpa dentária de dois cadávere...

Reparative dentin formation using stem cell therapy versus calcium hydroxide in direct pulp capping: an animal study

Braz. dent. j; 30 (6), 2019
Abstract Direct pulp capping process is a therapeutic method aimed at maintenance of pulp vitality and health by using a biocompatible material placed directly over the exposed pulp. The aim of this study was to evaluate and compare the effect of direct pulp capping procedures by dental pulp stem cells (...

Transplante Hepatocitário: uma alternativa terapêutica para a insuficiência hepática aguda

Dentre as doenças hepáticas que acometem o fígado, a insuficiência hepática aguda (IHA) destaca-se pela rápida perda da função hepática, com um alto índice de mortalidade que, em alguns estudos clínicos, pode chegar a 80%. A causa mais comum de IHA no Brasil é a hepatite viral, seguida pela h...

Mesenchymal Stromal Cells Modulate PAF-stimulated Equine Alveolar Macrophages

Abstract Platelet-activating factor (PAF) is a potent proinflammatory mediator that is produced in increased amounts in the lungs of asthmatic humans and horses. The present pilot study, shows that mesenchymal stromal cells can modulate alveolar macrophage function in asthma, interfering in the activity ...

Expression patterns of mesenchymal stem cell-specific proteins in adipose tissue-derived cells: possible immunosuppressing agent in partial allograft for restoring the urinary bladder in rabbits

Pesqui. vet. bras; 38 (12), 2018
Adipose tissue-derived stem cells (ADSCs) are an attractive source of mesenchymal stem cells (MSCs) for use in tissue engineering and clinical applications. This paper focuses on the characterization of ADSCs used as immunosuppressive agent in rabbits undergoing partial allograft for urine bladder restor...

Células mononucleares autólogas en la reparación de defectos óseos provocados por la periodontitis crónica
Autologous mononuclear cells in the repair of bone defects caused by chronic periodontitis

Introducción: la periodontitis crónica es un proceso inflamatorio de origen bacteriano que afecta a los tejidos del periodonto y provoca la destrucción de los tejidos de soporte del diente. La terapia celular con células mononucleares autólogas constituye una nueva opción terapéutica para lograr l...

Vascular endothelial growth factor association with angiopoietin 1 promotes improvement in ventricular function after ischemic cardiomyopathy induced in mini pigs

Acta cir. bras; 33 (4), 2018
Abstract Purpose: To investigate the safety and clinical, hemodynamic and tissue improvement ability in mini pigs undergoing cell and gene therapy for the treatment of acute myocardial infarction. Methods: Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarct...

Adult stem cells in the healing of fractures and bone grafts

Rev. MVZ Córdoba; 23 (1), 2018
ABSTRACT The traumatic accidents which result in fractures and even in impairment of a bone segment have a high prevalence in routine veterinary surgery. Many times these fractures are complex and difficulty healing or need bone grafts to preserve and restore the length of the affected limb. Thus, the re...

Bone-Marrow-Derived Mesenchymal Stromal Cells (MSC) from Diabetic and Nondiabetic Rats Have Similar Therapeutic Potentials

Arq. bras. cardiol; 109 (6), 2017
Abstract Background: Diabetes mellitus is a severe chronic disease leading to systemic complications, including cardiovascular dysfunction. Previous cell therapy studies have obtained promising results with the use bone marrow mesenchymal stromal cells derived from healthy animals (MSCc) in diabetes ani...