O papilomavírus humano (HPV) subtipo 16 é um fator de risco para o desenvolvimento do carcinoma espinocelular (CEC) de orofaringe. No entanto, o papel do mesmo na carcinogênese oral, bem como a associação com as lesões potencialmente malignas, permanece controverso. O objetivo deste estudo foi comp...
Esta pesquisa tem por objetivo analisar a recidiva, a sobrevida e fatores prognósticos em pacientes com câncer de cavidade oral (CCO), diagnosticados e atendidos no Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA), no período de 1999 a 2009. A tese é apresentada em dois artigos qu...
O hormônio glicoproteico estaniocalcina 2 (STC2) está envolvido na carcinogênese e progressão de muitos tipos de câncer. No entanto, seu significado clínico e mecanismos moleculares no carcinoma de células escamosas oral (CCEO) foram pouco estudados e permanecem incertos. O presente estudo investi...
Carcinoma de Células Escamosas de Cabeza y Cuello/patología,
Neoplasias de la Boca/patología,
Fibroblastos Asociados al Cáncer/patología,
Biomarcadores de Tumor,
Pronóstico,
Análisis de Supervivencia,
Inmunohistoquímica/métodos,
Técnicas In Vitro/métodos,
Carcinogénesis,
Técnicas de Cultivo de Célula,
Estadísticas no Paramétricas,
Análisis de Varianza
Introduction: Oral cancer ranks fifth among the most frequent malignant tumors in men
in Brazil. The incidence of this tumor among women has grown. It is still controversial
whether gender can influence the outcome or the prognostic features of the disease.
Objectives: To compare the histopathological fe...
Abstract To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtained from male and female patients aged over 30 years with...
Background: The development of oral cavity cancer is related to the accumulation of genetic alterations. The
activation of AKT is associated with the proliferation and progression of many malignancies. It is thought that MAP kinases, together with the PI3K/AKT/mTOR signaling pathway, promote uncoordinate...
Abstract The aim of this study was to identify the expression of Ki-67 and MCM3 in oral squamous cell carcinoma (OSCC) as well as to address the correlation with patient survival and clinical features. Samples were collected from 51 patients with OSCC who presented for follow-up. Immunohistochemical expr...
Factores de Edad,
Biopsia,
Carcinoma de Células Escamosas/metabolismo,
Carcinoma de Células Escamosas/mortalidad,
Carcinoma de Células Escamosas/patología,
Inmunohistoquímica,
Estimación de Kaplan-Meier,
Antígeno Ki-67/análisis,
Antígeno Ki-67/metabolismo,
Metástasis Linfática,
Persona de Mediana Edad,
Componente 3 del Complejo de Mantenimiento de Minicromosoma/metabolismo,
Neoplasias de la Boca/metabolismo,
Neoplasias de la Boca/mortalidad,
Neoplasias de la Boca/patología,
Proteínas de Neoplasias/metabolismo,
Estadificación de Neoplasias,
Adhesión en Parafina,
Valores de Referencia,
Factores Sexuales,
Factores de Tiempo,
Carga Tumoral
Abstract: The aim of this study was to evaluate the health-related quality of life (QOL) of patients with squamous cell carcinoma (SCC) according to tumor location. The sample consisted of 27 patients with primary SCC in the oral cavity (n = 15), pharynx (n = 7), and larynx (n = 5) who were undergoing ca...
Factores de Edad,
Análisis de Varianza,
Antineoplásicos/uso terapéutico,
Carcinoma de Células Escamosas/tratamiento farmacológico,
Carcinoma de Células Escamosas/patología,
Estudios Transversales,
Neoplasias Laríngeas/tratamiento farmacológico,
Neoplasias Laríngeas/patología,
Persona de Mediana Edad,
Neoplasias de la Boca/tratamiento farmacológico,
Neoplasias de la Boca/patología,
Estadificación de Neoplasias,
Neoplasias Faríngeas/tratamiento farmacológico,
Neoplasias Faríngeas/patología,
Calidad de Vida,
Factores Sexuales,
Encuestas y Cuestionarios
Abstract Plasmablastic lymphoma is a non-Hodgkin lymphoma characterized by its plasmacytic differentiation and predilection for the oral cavity. It is among the lymphomas most commonly associated with AIDS. This report details a case of a HIV-positive patient with a 1-month history of an exophytic mass i...
Síndrome de Inmunodeficiencia Adquirida/complicaciones,
Síndrome de Inmunodeficiencia Adquirida/patología,
Biopsia,
Inmunohistoquímica,
Linfoma Relacionado con SIDA/patología,
Linfoma Relacionado con SIDA/terapia,
Neoplasias de la Boca/patología,
Neoplasias de la Boca/terapia,
Neoplasias de la Boca/virología,
Linfoma Plasmablástico/patología,
Linfoma Plasmablástico/terapia,
Linfoma Plasmablástico/virología
