ABSTRACT The antifungal activity of tacrolimus in combination with antifungal agents against different fungal species has been previously reported. Here we report the in vitro interactions between tacrolimus and amphotericin B, fluconazole, itraconazole, and caspofungin against 30 clinical isolates of bo...
Anfotericina B/farmacología,
Antifúngicos/farmacología,
Inhibidores de la Calcineurina/farmacología,
Caspofungina,
Interacciones Farmacológicas,
Sinergismo Farmacológico,
Equinocandinas/farmacología,
Fluconazol/farmacología,
Itraconazol/farmacología,
Lipopéptidos/farmacología,
Pruebas de Sensibilidad Microbiana,
Tacrolimus/farmacología,
Trichosporon/efectos de los fármacos
Neves, Francelli Cordeiro;
Clemente, Wanessa T;
Lincopan, Nilton;
Paião, Isabela D;
Neves, Patrícia R;
Romanelli, Roberta M;
Lima, Stella S S;
Paiva, Luciene F;
Mourão, Paulo Henrique O;
Nobre-Junior, Vandack A.
ABSTRACT Background: Carbapenem-resistant Acinetobacter baumannii (CRAb) is an important cause of nosocomial infections especially in intensive care units. This study aimed to assess clinical aspects and the genetic background of CRAb among ICU patients at a Brazilian teaching hospital. Methods: 56 cri...
Infecciones por Acinetobacter/microbiología,
Acinetobacter baumannii/efectos de los fármacos,
Acinetobacter baumannii/enzimología,
Acinetobacter baumannii/genética,
Antibacterianos/farmacología,
Brasil,
Infección Hospitalaria/microbiología,
Genotipo,
Hospitales de Enseñanza,
Unidades de Cuidados Intensivos,
Pruebas de Sensibilidad Microbiana,
Reacción en Cadena de la Polimerasa Multiplex,
Estudios Prospectivos,
beta-Lactamasas/biosíntesis,
beta-Lactamasas/genética
ABSTRACT Novel strategies to combat the ever increasing burden of drug resistance in Mycobacterium tuberculosis (MTB) causing tuberculosis (TB) remains a global concern. The ability of MTB to sense and adapt to restricted iron conditions in the hostile environment is essential for their survival and conf...
ABSTRACT Objective: The aim of this study was to evaluate the effect of licorice in H. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (PUD) or non-ulcer dyspepsia (NUD) in comparison to the clarithromycin-based standard triple regimen. Methods: In this randomiz...
Antibacterianos/uso terapéutico,
Claritromicina/uso terapéutico,
Dispepsia/tratamiento farmacológico,
Dispepsia/microbiología,
Glycyrrhiza/química,
Infecciones por Helicobacter/tratamiento farmacológico,
Helicobacter pylori/efectos de los fármacos,
Úlcera Péptica/tratamiento farmacológico,
Úlcera Péptica/microbiología,
Extractos Vegetales/uso terapéutico,
Resultado del Tratamiento
ABSTRACT PURPOSE: To investigate the role of bradykinin in a rat lung transplantation (LTx) model and preliminarily discuss the relationship between bradykinin and CD26/DPP-4. METHODS: Rats were randomly divided into four groups: Control (CON), Sham, low potassium dextranglucose (LPD), and AB192 (n=15...
Bradiquinina/fisiología,
Dipeptidil Peptidasa 4/fisiología,
Trasplante de Pulmón,
Pulmón/irrigación sanguínea,
Disfunción Primaria del Injerto/patología,
Daño por Reperfusión/patología,
Western Blotting,
Antagonistas del Receptor de Bradiquinina B2/metabolismo,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Peroxidación de Lípido,
Pulmón/efectos de los fármacos,
Disfunción Primaria del Injerto/fisiopatología,
Distribución Aleatoria,
Daño por Reperfusión/metabolismo,
Daño por Reperfusión/fisiopatología
ABSTRACT PURPOSE: To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy´s criteria evaluation. METHODS: Sixty-one Wistar female rats were distributed into three grou...
ABSTRACT PURPOSE: To investigate the effect of silymarin on oxidative stress and hepatic injury induced by obstructive jaundice in an experimental model. METHODS: Thirty Wistar-Albino type female rats were divided into 3 groups each including 10 rats. Only laparotomy was performed in group 1. Bile du...
Antioxidantes/farmacología,
Ictericia Obstructiva/complicaciones,
Hígado/patología,
Estrés Oxidativo/efectos de los fármacos,
Silimarina/farmacología,
Conductos Biliares,
Glutatión/sangre,
Ictericia Obstructiva/patología,
Ligadura,
Malondialdehído/sangre,
Sustancias Protectoras/farmacología,
Distribución Aleatoria,
Ratas Wistar
ABSTRACT PURPOSE: To evaluate the role of low molecular chitosan containing sepia ink (LMCS) in ethanol-induced (5 ml/kg) gastric ulcer in rats. METHODS: Animals were divided into four groups (n = 12): normal group (Normal), negative control group (Con), experiment group (LMCS) and positive control Om...
Antiulcerosos/uso terapéutico,
Antioxidantes/farmacología,
Quitosano/uso terapéutico,
Mucosa Gástrica/efectos de los fármacos,
Sepia/química,
Úlcera Gástrica/tratamiento farmacológico,
Antioxidantes/metabolismo,
Quitosano/química,
Modelos Animales de Enfermedad,
Etanol,
Mucosa Gástrica/patología,
Hidroxiprolina/metabolismo,
Tinta,
Malondialdehído/metabolismo,
Peso Molecular,
Distribución Aleatoria,
Úlcera Gástrica/inducido químicamente
ABSTRACT PURPOSE: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintaine...
Cocos/química,
Sepsis/tratamiento farmacológico,
Choque Hemorrágico/tratamiento farmacológico,
Simvastatina/administración & dosificación,
Agua,
Cacao,
Modelos Animales de Enfermedad,
Inhibidores de Hidroximetilglutaril-CoA Reductasas/administración & dosificación,
Riñón/efectos de los fármacos,
Hígado/efectos de los fármacos,
Pulmón/efectos de los fármacos,
Ratas Wistar,
Resucitación/métodos,
Cloruro de Sodio/administración & dosificación
Guillén, Rosa;
Carpinelli, Letizia;
Rodríguez, Fátima;
Castro, Héctor;
Quíñónez, Beatriz;
Campuzano, Ana;
Macchi, María;
Ortellado, Juana;
Almada, Patricia;
Grau, Lorena;
Rodríguez, Mónica;
Velázquez, Gladys;
Espínola, Carmen;
Samudio, Gloría;
Gómez, Gloria;
Basualdo, Wilma.
Introduction: The prevalence of Staphylococcus aureus in the community has increased, being the pediatric population the most affected. This fact highlights the need for epidemiological surveillance. Aim: To characterize clinical, phenotypic and genotypic isolates of S. aureus children’s samples wi...
Proteínas Bacterianas/genética,
Toxinas Bacterianas/genética,
Exotoxinas/genética,
Leucocidinas/genética,
Proteínas de Unión a las Penicilinas/genética,
Infecciones Estafilocócicas/microbiología,
Staphylococcus aureus/efectos de los fármacos,
Staphylococcus aureus/genética,
Infecciones Comunitarias Adquiridas/microbiología,
Estudios Transversales,
Genotipo,
Paraguay,
Fenotipo,
Reacción en Cadena de la Polimerasa,
Prevalencia
