SUMMARY PURPOSE: To investigate the contribution of the deletion polymorphism and insertion (rs1799752) of the angiotensin converting enzyme (ACE) gene in the aetiology of Polycystic Ovarian Syndrome (PCOS). METHODOLOGY: 97 women diagnosed with PCOS who received care at the Gynaecology and Obstetrics c...
ABSTRACT Objective: To investigate the potential relationship between the human leukocyte antigen (HLA) type (class I and II) and the response to several disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS). Methods: We analyzed clinical data of 87 patients with MS at the beginni...
Alelos,
Progresión de la Enfermedad,
Frecuencia de los Genes/genética,
Predisposición Genética a la Enfermedad,
Genotipo,
Antígenos HLA/genética,
Antígenos HLA-D/genética,
Inmunosupresores/uso terapéutico,
Esclerosis Múltiple Recurrente-Remitente/tratamiento farmacológico,
Esclerosis Múltiple Recurrente-Remitente/genética,
Índice de Severidad de la Enfermedad,
Factores de Tiempo,
Resultado del Tratamiento
Andrade, Elisabete;
Rocha, Daniele;
Fontana-Maurell, Marcela;
Costa, Elaine;
Ribeiro, Marisa;
de Godoy, Daniela Tupy;
Ferreira, Antonio G P;
Tanuri, Amilcar;
Alvarez, Patrícia;
Brindeiro, Rodrigo.
ABSTRACT The Brazilian Public Health Service provides freely αPEG-IFN to treat patients infected with HCV. The primary goal of HCV therapy is the long-term elimination of HCV from the blood to reduce the risk of HCV associated complications and death. Patient viremia affects the treatment duration a...
Antivirales/uso terapéutico,
Brasil,
Genotipo,
Técnicas de Genotipaje,
Hepacivirus/genética,
Hepacivirus/aislamiento & purificación,
Hepatitis C/sangre,
Hepatitis C/tratamiento farmacológico,
Hepatitis C/virología,
Interferón-alfa/uso terapéutico,
Polietilenglicoles/uso terapéutico,
Estudios Prospectivos,
ARN Viral/sangre,
ARN Viral/genética,
ARN Viral/aislamiento & purificación,
Reacción en Cadena en Tiempo Real de la Polimerasa/métodos,
Proteínas Recombinantes/uso terapéutico,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Carga Viral/métodos,
Viremia
ABSTRACT Objective: To determine the role of extended-spectrum β-lactamases in carbapenem-resistant Gram-negative bacteria from south-western Nigeria. Methods: Twenty-seven carbapenem-resistant isolates that were found to be non-carbapenemase producers (15 Escherichia coli, 9 Klebsiella pneumoniae...
Escherichia coli/efectos de los fármacos,
Klebsiella pneumoniae/efectos de los fármacos,
Pseudomonas aeruginosa/efectos de los fármacos,
Fenotipo,
Genotipo,
beta-Lactamasas/biosíntesis,
Escherichia coli/enzimología,
Klebsiella pneumoniae/enzimología,
Pseudomonas aeruginosa/enzimología,
Nigeria,
Pruebas de Sensibilidad Microbiana,
Antibacterianos/farmacología,
Farmacorresistencia Microbiana
Alves, Daniella de Sousa Mendes Moreira;
Gonçalves, Gustavo Souza;
Moraes, Aline Silva;
Alves, Luciano Moreira;
Carmo Neto, José Rodrigues do;
Hecht, Mariana Machado;
Nitz, Nadjar;
Gurgel-Gonçalves, Rodrigo;
Bernardes, Geisa;
Castro, Ana Maria de;
Chalita, Maria Regina;
Vinaud, Marina Clare.
Abstract We report an Acanthamoeba keratitis case associated with the use of contact lens in a 28-year-old female from Brasília, Brazil. Samples from corneal scraping and contact lens case were used for culture establishment, PCR amplification, and partial sequencing (fragments of ~400kb) of small subun...
SUMMARY Congenital hyperinsulinism (CHI) is a heterogenous disease caused by insulin secretion regulatory defects, being ABCC8/KCNJ11 the most commonly affected genes. Therapeutic options include diazoxide, somatostatin analogues and surgery, which is curative in focal CHI. We report the case of two sibl...
Hiperinsulinismo Congénito/genética,
Hiperinsulinismo Congénito/terapia,
Diazóxido/uso terapéutico,
Genotipo,
Mutación/genética,
Pancreatectomía/métodos,
Fenotipo,
Hermanos,
Somatostatina/análisis,
Receptores de Sulfonilureas/genética,
Resultado del Tratamiento
ABSTRACT Objective: The clinical, functional, radiological and genotypic descriptions of patients with an alpha-1 antitrypsin (A1AT) gene mutation in a referral center for COPD in Brazil. Methods: A cross-sectional study of patients with an A1AT gene mutation compatible with deficiency. We evaluated th...
Abstract Objectives: The aims of the study were to determine the frequency of hepatobiliary disease in patients with cystic fibrosis and to describe the sociodemographic, clinical, and laboratory profile of these patients. Methods: This was a retrospective, descriptive, and analytical study of 55 patie...
SUMMARY BACKGROUND: There is evidence of detection of Helicobacter pylori (H. pylori) in the stool of newborns and in the yeast that colonizes the oral cavity of this age group. However, there is a lack of research to confirm it. This study proposes to determine the existence of the bacteria at an early...
Antígenos Bacterianos,
Candida glabrata/aislamiento & purificación,
Estudios Transversales,
Heces/microbiología,
Genotipo,
Infecciones por Helicobacter/microbiología,
Helicobacter pylori/genética,
Helicobacter pylori/aislamiento & purificación,
Mucosa Bucal/microbiología,
Reacción en Cadena de la Polimerasa,
Saliva/microbiología
