ABSTRACT Purpose: In a previous study the vaccine was effective against bladder cancer in a mouse model. However, a small portion of tumors regrew because the vaccine could not eliminate bladder cancer stem cells (CSCs). In this study, we showed a modified method for the isolation of bladder CSCs using ...
Biomarcadores de Tumor,
Vacunas contra el Cáncer/inmunología,
Adhesión Celular/efectos de los fármacos,
Técnicas de Cultivo de Célula/métodos,
Diferenciación Celular,
Línea Celular Tumoral,
Separación Celular/métodos,
Medio de Cultivo Libre de Suero,
Citometría de Flujo,
Ratones Desnudos,
Células Madre Neoplásicas/química,
Células Madre Neoplásicas/citología,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Tripsina/farmacología,
Neoplasias de la Vejiga Urinaria/patología
ABSTRACT Introduction: We investigate the effect of active peptide from Urechis unicinctus (UU) by high temperature/pressure and ultra-wave assisted lysis on erectile dysfunction in streptozotocin-induced diabetic rats. Materials and Methods: Forty 12-week-old Sprague-Dawley rats were used in this stud...
Anélidos/química,
Células Cultivadas,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/complicaciones,
Disfunción Eréctil/tratamiento farmacológico,
Disfunción Eréctil/etiología,
Disfunción Eréctil/fisiopatología,
Pene/efectos de los fármacos,
Péptidos/análisis,
Péptidos/farmacología,
Péptidos/uso terapéutico,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Estreptozocina,
Temperatura
This report describes two cases of male cats affected by FLUTD (Feline lower urinary tract disease). The first patient had been affected by numerous relapses after passing through various therapeutic treatments and surgical interventions, and was subjected to the alternative protocol after being recommen...
Abstract Objective Analyze nasal colonization by oxacillin-sensitive and oxacillin-resistant Staphylococcus aureus in people with HIV/AIDS (PWHA) at days 1 and7 of hospitalization. METHOD A prospective observational study conducted in a hospital in the countryside of the state of São Paulo. Nasal swab...
ABSTRACT Purpose: The objective of this study was to evaluate subfoveal choroidal thickness (SFCT) using enhanced depth imaging optical coherence tomography (EDI-OCT) in patients with naïve branch retinal vein occlusion (BRVO) before and after intravitreal dexamethasone implant (Ozurdex®) injection. ...
Estudios de Casos y Controles,
Coroides/diagnóstico por imagen,
Coroides/efectos de los fármacos,
Dexametasona/administración & dosificación,
Glucocorticoides/administración & dosificación,
Presión Intraocular,
Inyecciones Intravítreas,
Edema Macular/prevención & control,
Estudios Prospectivos,
Valores de Referencia,
Oclusión de la Vena Retiniana/diagnóstico por imagen,
Oclusión de la Vena Retiniana/tratamiento farmacológico,
Estadísticas no Paramétricas,
Factores de Tiempo,
Tomografía de Coherencia Óptica/métodos,
Resultado del Tratamiento,
Agudeza Visual
RESUMO Objetivo Avaliar o efeito da suplementação com ômega-3 nas subfrações das lipoproteínas de alta densidade em indivíduos tabagistas. Métodos Ensaio clínico, randomizado, duplo-cego. Foi selecionada uma amostra com 33 tabagistas, de ambos os sexos, com idade entre 30 e 60 anos, suplementa...
RESUMO Objetivo: Investigar os efeitos da vitamina C sobre níveis de peroxidação lipídica e glutationa reduzida em tecido hepático de camundongos imunossuprimidos por ciclofosfamida. Métodos: O estudo foi realizado em camundongos Swiss, fêmeas, com 45 dias de idade, separados em quatro grupos co...
Abstract Background and objective: Sugammadex is the first selective relaxant binding agent. When compared with neostigmine, following sugammadex administration patients wake earlier and have shorter recovery times. In this study, we hypothesized that fast and clear awakening in patients undergoing gene...
ABSTRACT CONTEXT AND OBJECTIVE: Dementia is a syndrome characterized by functional and cognitive decline. Alzheimer's disease (AD) is one of the most common causes of dementia and has high prevalence among the elderly. It is known that there is no drug capable of interfering with the course of the dise...
Abstract Background: Thyroid hormone deficiency during fetal life could affect the cardiac function in later life. The mechanism underlying this action in fetal hypothyroidism (FH) in rats has not been elucidated thus far. Objective: The aim of this study is to evaluation the effect of FH on cardiac ...
Antitiroideos,
Peso Corporal/efectos de los fármacos,
Hipotiroidismo Congénito/sangre,
Hipotiroidismo Congénito/inducido químicamente,
Hipotiroidismo Congénito/metabolismo,
ADN Complementario/metabolismo,
Modelos Animales de Enfermedad,
Frecuencia Cardíaca,
Miocardio/metabolismo,
Cadenas Pesadas de Miosina/metabolismo,
Propiltiouracilo,
ARN Mensajero/metabolismo,
Distribución Aleatoria,
Ratas Wistar,
Tiroxina/sangre,
Triyodotironina/sangre,
Presión Ventricular
