Abstract Purpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM). Methods: The study featured 4 control groups (I-IV) and 4 experimental groups (V-VIII), totaling 48 rats. Once a week for 2 weeks, animals on control groups r...
Azoximetano,
Carcinógenos,
Neoplasias Colorrectales/inducido químicamente,
Neoplasias Colorrectales/prevención & control,
Modelos Animales de Enfermedad,
Goma Arábiga/farmacología,
Lisina/farmacología,
Estrés Oxidativo/efectos de los fármacos,
Lesiones Precancerosas/inducido químicamente,
Lesiones Precancerosas/prevención & control,
Própolis/farmacología,
Ratas Wistar
Abstract Purpose: To investigate the effects of icariside II on brain tissue oxidative stress and Nrf2/HO-1 expression in rats with cerebral ischemia-reperfusion injury (CIRI). Methods: One hundred SD rats were randomly divided into sham-operated, model, and 5, 10 and 20 mg/kg icariside II groups, 20 ...
Isquemia Encefálica/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Flavonoides/uso terapéutico,
Factor 2 Relacionado con NF-E2/efectos de los fármacos,
Factor 2 Relacionado con NF-E2/metabolismo,
Fármacos Neuroprotectores,
Estrés Oxidativo/efectos de los fármacos,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Daño por Reperfusión/tratamiento farmacológico,
Índice de Severidad de la Enfermedad
The natural flavonoid glycoside baicalin (BA) produces a variety of pharmaceutical effects, particularly for psychiatric/neurological disorders. This study evaluated the behavioral and neuroprotective effects of BA in mice subjected to chronic unpredictable mild stress, a model of depression. BA (25 and ...
Trastorno Depresivo/tratamiento farmacológico,
Trastorno Depresivo/metabolismo,
Trastorno Depresivo/psicología,
Modelos Animales de Enfermedad,
Flavonoides/administración & dosificación,
Suspensión Trasera/psicología,
Interleucina-1beta/sangre,
Interleucina-6/sangre,
Ratones Endogámicos C57BL,
Estrés Oxidativo/efectos de los fármacos,
Factor de Necrosis Tumoral alfa/sangre
Dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptors, has anti-inflammation properties and potential beneficial effects against trauma, shock, or infection. Therefore, this study aimed to investigate whether DEX might protect against multiple-organ dysfunction in a two-hit model of ...
Biomarcadores/sangre,
Dexmedetomidina/uso terapéutico,
Modelos Animales de Enfermedad,
Endotoxemia/tratamiento farmacológico,
Endotoxemia/patología,
Hemorragia/tratamiento farmacológico,
Hemorragia/patología,
Insuficiencia Multiorgánica/tratamiento farmacológico,
Insuficiencia Multiorgánica/patología,
Estrés Oxidativo/efectos de los fármacos,
Sustancias Protectoras/uso terapéutico,
Ratas Wistar,
Receptores Adrenérgicos beta 2/efectos de los fármacos,
Receptores Adrenérgicos beta 2/metabolismo,
Resucitación,
Factores de Tiempo
OBJECTIVES: Intestinal obstruction has a high mortality rate when therapeutic treatment is delayed. Resuscitation in intestinal obstruction requires a large volume of fluid, and fluid combinations have been studied. Therefore, we evaluated the effects of hypertonic saline solution (HS) with pentoxifyllin...
Apoptosis/efectos de los fármacos,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Etiquetado Corte-Fin in Situ,
Obstrucción Intestinal/metabolismo,
Obstrucción Intestinal/mortalidad,
Obstrucción Intestinal/prevención & control,
Intestino Delgado/efectos de los fármacos,
Intestino Delgado/metabolismo,
Estimación de Kaplan-Meier,
Riñón/efectos de los fármacos,
Riñón/metabolismo,
Peroxidación de Lípido/efectos de los fármacos,
Malondialdehído/análisis,
Estrés Oxidativo/efectos de los fármacos,
Pentoxifilina/farmacología,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Resucitación/métodos,
Solución Salina Hipertónica/farmacología
OBJECTIVES: The aim of this study was to investigate the effects of aquatic exercise on mental health, functional autonomy and oxidative stress parameters in depressed elderly individuals. METHODS: Initially, ninety-two elderly individuals were included in the study and were allocated into the depressio...
SUMMARY: In spite of being one of the most powerful anti-cancer drug, the nephrotoxicity of Vincristine (VCR) is not well established in either animals or humans. Hence, this study evaluates the nephrotoxic effect of VCR in rats after sub-chronic long-term administration. Rats were divided into 2 groups ...
Vincristina/toxicidad,
Enfermedades Renales/inducido químicamente,
Estrés Oxidativo/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Riñón/efectos de los fármacos,
MAP Quinasa Quinasa 1,
Proteína Quinasa 3 Activada por Mitógenos,
Sistema de Señalización de MAP Quinasas,
Ratas Wistar,
Creatinina/sangre,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Western Blotting,
Riñón/patología,
Tasa de Supervivencia,
ARN Mensajero,
Urea/sangre,
Necrosis
SUMMARY: This study aimed to investigate the toxic effects of cigarette smoke exposure on lung and the protective role of Omega 3 and Vitamin D against these toxic effects biochemically and histologically. 28 pregnant Wistar Albino rats were divided into four groups. The first group was control group; th...
Ácidos Grasos Omega-3/administración & dosificación,
Vitamina D/administración & dosificación,
Animales Recién Nacidos,
Exposición Materna/efectos adversos,
Lesión Pulmonar/prevención & control,
Lesión Pulmonar/inducido químicamente,
Nicotina/toxicidad,
Lesión Pulmonar/patología,
Humo/efectos adversos,
Malondialdehído/análisis,
Estrés Oxidativo,
Fluorescencia,
Ratas Wistar,
Análisis de Varianza,
Feto/efectos de los fármacos
Abstract This study aimed to investigate the cardioprotection of rosuvastatin pre-conditioning (R-Pre) in a rat model of myocardial ischemia / reperfusion (I/R). Male SD rats were assigned into three groups: sham group, I/R group and R-Pre group. Rats in I/R group and R-Pre group received ischemia for 30...
Santos, J M;
Mendonça, V A;
Ribeiro, V G C;
Tossige-Gomes, R;
Fonseca, S F;
Prates, A C N;
Flor, J;
Oliveira, A C C;
Martins, J B;
Garcia, B C C;
Leite, H R;
Figueiredo, P H S;
Bernardo-Filho, M;
Lacerda, A C R.
The objective of this study was to investigate the effect of whole body vibration (WBV) exercise on oxidative stress markers in a group of women with fibromyalgia (FM) compared to a group of healthy women (CT). Twenty-one women diagnosed with FM and 21 age- and weight-matched healthy women were enrolled ...
