Paracetamol (PCM) overdose can cause hepatotoxicity with oxidative stress; the present study was carried out to establish the possible protective effect of olive leaves extract (OLE) on toxicity induced by paracetamol in adult male rats. Twenty four adult male rats were divided into four equal groups; co...
Acetaminofén/toxicidad,
Olea,
Estrés Oxidativo/efectos de los fármacos,
Antioxidantes/farmacología,
Oxidantes,
Extractos Vegetales/farmacología,
Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control,
Medicamentos Hepatoprotectores,
Hojas de la Planta,
Extractos Vegetales/química,
Hígado/patología,
Hepatocitos/efectos de los fármacos,
Distribución Aleatoria,
Ratas Endogámicas,
Ratas Wistar
Background: The harmful effects of type 2 diabetes mellitus and its complications have become a major global public health problem. In this study, the effects of Momordica charantia saponins (MCS) on lipid metabolism, oxidative stress, and insulin signaling pathway in type 2 diabetic rats were investigat...
Diabetes Mellitus Experimental/tratamiento farmacológico,
Momordica charantia/química,
Saponinas/uso terapéutico,
Saponinas/farmacología,
Ratas Wistar,
Hipoglucemiantes/farmacología,
Hipoglucemiantes/uso terapéutico,
Estrés Oxidativo/efectos de los fármacos,
Resistencia a la Insulina,
Lípidos,
Glucemia/efectos de los fármacos,
Peso Corporal,
Hígado/efectos de los fármacos,
Páncreas/efectos de los fármacos
Wunderlich, A L M;
Azevedo, S C S F;
Yamada, L A;
Bataglini, C;
Previate, C;
Campanholi, K S S;
Pereira, P C S;
Caetano, W;
Kaplum, V;
Nakamura, C V;
Nakanishi, A B S;
Comar, J F;
Pedrosa, M M D;
Godoi, V A F.
Photodynamic therapy (PDT) promotes cell death, and it has been successfully employed as a treatment resource for neuropathic complications of diabetes mellitus (T1DM) and hepatocellular carcinoma. The liver is the major organ involved in the regulation of energy homeostasis, and in pathological conditio...
Clorofila/administración & dosificación,
Clorofila/análogos & derivados,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/patología,
Quimioterapia Combinada,
Metabolismo Energético/efectos de los fármacos,
Glucólisis/efectos de los fármacos,
Glucólisis/fisiología,
Hígado/patología,
Hígado/fisiopatología,
Estrés Oxidativo/efectos de los fármacos,
Estrés Oxidativo/fisiología,
Fotoquimioterapia,
Fármacos Fotosensibilizantes/administración & dosificación,
Ratas Wistar
A dieta hipercalórica é considerada fator de risco para o desenvolvimento de doenças cardiovasculares,
sendo notado que os hábitos ocidentais possuem uma grande influência no desenvolvimento
dessas enfermidades. A biomassa e a farinha de banana verde são alimentos que contém amido
resistente; este...
Abstract Objective: The phytohormone abscisic acid (ABA) as a signaling molecule exists in various types of organisms from early multicellular to animal cells and tissues. It has been demonstrated that ABA has an antinociceptive effect in rodents. The present study was designed to assess the possible r...
Ácido Abscísico/farmacología,
Analgésicos/farmacología,
Western Blotting,
Proteínas Quinasas Dependientes de AMP Cíclico/análisis,
Proteínas Quinasas Dependientes de AMP Cíclico/efectos de los fármacos,
Quinasas MAP Reguladas por Señal Extracelular/análisis,
Quinasas MAP Reguladas por Señal Extracelular/efectos de los fármacos,
Péptidos y Proteínas de Señalización Intracelular/farmacología,
Reguladores del Crecimiento de las Plantas/farmacología,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Médula Espinal/efectos de los fármacos,
Médula Espinal/metabolismo,
Factores de Tiempo
Abstract The objective of this study was to investigate the effects of low-level laser therapy (LLLT) and cigarette smoke on alveolar socket osteoclastogenesis signaling after tooth extraction, in rats. Sixty male Wistar rats were randomly assigned to four groups with 15 animals each: Control Group (with...
Silva, Lorena Doretto da;
Veridiano, Juliana Mora;
Oliveira, Jussara Celi Conceição;
Sayeg, Anna Carolina Haddad;
Mader, Ana Maria Amaral Antonio;
Petri, Giuliana;
Bianco, Bianca;
Fernandes, César Eduardo;
Toledo, Olga Maria Szymanski de;
Pompei, Luciano de Melo;
Steiner, Marcelo Luis.
Abstract Objective The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of ovariectomized rats and the visceral and subcutaneous fat expression of peroxisome proliferator-activated receptors (PPARs) gamma....
O fipronil é um inseticida de toxicidade seletiva amplamente empregado na agricultura e na medicina veterinária. Porém, há relatos de efeitos neurotóxicos dessa substância, que geram prejuízos para vertebrados. Avaliou-se a atividade locomotora, a coordenação motora e a atividade da enzima aceti...
OBJECTIVES: In cirrhotic children, infection events and sepsis are more frequent and more severe due to immune dysfunction. The objectives of the current study were therefore to develop an experimental model of infection and sepsis in cirrhotic weaning growing rats, by the use of bile duct ligation (BDL)...
Metabolic syndrome is a multifaceted condition associated with a greater risk of various disorders (e.g., diabetes and heart disease). In a rat model of metabolic syndrome, an acute in vitro application of rosuvastatin causes relaxation of aortic rings. Since the outcome of a subchronic rosuvastatin trea...
