Objective : to evaluate the effect of topical delivery of latex cream-gel in acute cutaneous wounds induced on the back of rats. Methods : we subjected sixteen rats to dermo-epidermal excision of a round dorsal skin flap, with 2.5cm diameter. We divided the animals into two groups: Latex Group: applicat...
PURPOSE: To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three weeks as a recovery period, 6-OHDA-induced brady...
Antagonistas del Receptor de Adenosina A2/farmacología,
Cafeína/farmacología,
Oxidopamina/efectos adversos,
Enfermedad de Parkinson Secundaria/inducido químicamente,
Antagonistas de Receptores Purinérgicos P1/farmacología,
Modelos Animales de Enfermedad,
Hipocinesia/inducido químicamente,
Actividad Motora/efectos de los fármacos,
Trastornos Motores/inducido químicamente,
Ratas Wistar,
Estudios de Tiempo y Movimiento
Çakır, Tuğrul;
Aslaner, Arif;
Tekeli, Seçkin Özgür;
Avcı, Sema;
Doğan, Uğur;
Tekeli, Feyza;
Soylu, Hakan;
Akyüz, Cebrail;
Koç, Süleyman;
Üstünel, İsmail;
Yılmaz, Necat.
PURPOSE: To investigate the effects of medical ozone theraphy on the colon anastomosis of peritonitis model in rats. METHODS: Eighteen rats were randomly assigned into three equal groups; control, cecal punctuation and colon anastomosis and ozone theraphy. Sepsis was performed with a cecal punctuation in...
Colon/cirugía,
Ozono/farmacología,
Peritonitis/inducido químicamente,
Cicatrización de Heridas/efectos de los fármacos,
Anastomosis Quirúrgica,
Colon/patología,
Modelos Animales de Enfermedad,
Interleucina-1beta/análisis,
Interleucina-1beta/efectos de los fármacos,
Malondialdehído/análisis,
Peroxidasa/análisis,
Peroxidasa/efectos de los fármacos,
Distribución Aleatoria,
Ratas Wistar,
Factor de Necrosis Tumoral alfa/análisis,
Factor de Necrosis Tumoral alfa/efectos de los fármacos
PURPOSE: To detect whether chitin and sepia ink sponge (CS) can promote wound healing and elevate impact of CS on phagocytosis ability of macrophages. METHODS: Forty-eight rats were assigned to four groups: Normal group (Normal), negative control group (Con), chitin and sepia ink sponge group (CS) and po...
Quemaduras Químicas/tratamiento farmacológico,
Quitina/farmacología,
Macrófagos/efectos de los fármacos,
Sepia,
Cicatrización de Heridas/efectos de los fármacos,
Quitina/uso terapéutico,
Citocinas/efectos de los fármacos,
Citocinas/metabolismo,
Modelos Animales de Enfermedad,
Hidroxiprolina/metabolismo,
Tinta,
Macrófagos/metabolismo,
Metaloproteinasa 1 de la Matriz/efectos de los fármacos,
Fagocitosis/efectos de los fármacos,
Distribución Aleatoria,
Ratas Wistar
PURPOSE: To investigate the anticancer activity of ellagic acid (EA) in U251 human glioblastoma cells and its possible molecular mechanism. METHODS: The cells were treated with EA at various concentrations for different time periods. Cell viability and cell proliferation were detected by cell counting ki...
Apoptosis/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Ácido Elágico/farmacología,
Glioblastoma/metabolismo,
Apoptosis/fisiología,
Caspasa 3/metabolismo,
Supervivencia Celular/efectos de los fármacos,
Ácido Elágico/metabolismo,
Proteínas de Choque Térmico/efectos de los fármacos,
Proteínas de Choque Térmico/metabolismo,
Sistema de Señalización de MAP Quinasas/efectos de los fármacos,
Factor de Transcripción CHOP/efectos de los fármacos,
Factor de Transcripción CHOP/metabolismo
PURPOSE: To investigate the potential protective effect of allopurinol on reperfusion injury by determining the inflammatory response through the measurement of tumor necrosis factor-alpha (TNF-alpha). METHODS: Sixty rats were distributed into two groups: control and allopurinol and each group was divide...
Cavidad Abdominal/irrigación sanguínea,
Alopurinol/farmacología,
Antimetabolitos/farmacología,
Isquemia/cirugía,
Daño por Reperfusión/metabolismo,
Inflamación/metabolismo,
Modelos Animales,
Distribución Aleatoria,
Ratas Wistar,
Especies Reactivas de Oxígeno/metabolismo,
Daño por Reperfusión/prevención & control,
Factores de Tiempo,
Factor de Necrosis Tumoral alfa/análisis,
Factor de Necrosis Tumoral alfa/efectos de los fármacos
Background: The antimicrobial properties and molecular interaction analysis of curcumin and its derivatives against three different strains of Streptococcus pneumoniae (Penicillin-susceptible, Penicillin-intermediate and Penicillin-resistant) are studied. Results: These properties were analyzed based on ...
A doença de Chagas afeta cerca de 6 a 7 millhões de pessoas no mundo, principalmente América Latina. A busca de alternativas terapêuticas para esta enfermidade tem grande relevância para a sociedade, já que as opções atuais são limitadas, sendo disponível apenas o benznidazol (BZD) e nifurtimox...
Preparaciones Farmacéuticas,
Trypanosoma cruzi/efectos de los fármacos,
Nitrofuranos/análisis,
25873/efectos adversos,
Relación Estructura-Actividad,
Técnicas In Vitro/métodos,
Relación Estructura-Actividad Cuantitativa,
Oxidorreductasas,
Química Farmacéutica/métodos,
Nifurtimox/administración & dosificación,
Citotoxicidad Inmunológica
A diabetes mellitus (DM) é considerada uma das principais epidemias mundiais deste século, sendo responsável direta ou indiretamente pelo óbito de 123 mil diabéticos no Brasil em 2010. Na diabetes mellitus do tipo 1 (DM1), que corresponde a 5-10% dos casos, há ausência ou um relativo déficit de i...
Fatores dietéticos como o selênio (Se) são apontados como importantes moduladores do risco de desenvolvimento do câncer de mama. Essa neoplasia pode apresentar sua origem no início do desenvolvimento e, assim, a alimentação materna poderia ter importantes repercussões na programação fetal da do...
