Kruppel-like factor 6 (KLF6) is a member of the family of Kruppel transcription factors, this plays an important role in the regulation of cell growth, differentiation and angiogenesis. Rosiglitazone is a PPARy agonist drug, its antitumor effect has been described in models of breast and colon cancer. Th...
RESUMO Objetivo: Avaliar o impacto da terapia sobre a densidade mineral óssea (DMO) e composição corporal em sobreviventes da leucemia linfoide aguda (LLA), tratados de acordo com os protocolos brasileiros do Grupo Cooperativo Brasileiro de Tratamento de Leucemia Linfoide Aguda na Infância (GBTLI),...
Antineoplásicos/efectos adversos,
Protocolos Antineoplásicos,
Composición Corporal/efectos de los fármacos,
Composición Corporal/efectos de la radiación,
Densidad Ósea/efectos de los fármacos,
Densidad Ósea/efectos de la radiación,
Brasil,
Estudios Transversales,
Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico,
Leucemia-Linfoma Linfoblástico de Células Precursoras/radioterapia,
Radioterapia,
Radioterapia/efectos adversos,
Estudios Retrospectivos,
Factores de Tiempo
Abstract: Periungual and paronychia-like skin lesions can mimic various diseases, setting up a diagnostic challenge that invariably requires correlation with complementary tests. We report a case of an ulcerated tumor of the nailfold diagnosed as leishmaniasis. Although paronychia-like cutaneous leishman...
Abstract: In the recent past years, many discoveries in the tumor microenvironment have led to changes in the management of melanoma and it is rising up hopes, specially, to those in advanced stages. FDA approved seven new drugs from 2011 to 2014. They are: Vemurafenib, Dabrafenib and Trametinib, kinases...
A capecitabina é um agente quimioterápico indicado, dentre outros casos, como monoterapia no câncer de mama metastático. A síndrome mão-pé consiste numa das reações adversas associadas ao seu uso e caracteriza-se por eritema doloroso, edema, disestesia, descamação, bolhas e úlceras nas regiõ...
Abstract Identifying new chemotherapeutic agents with fewer side effects is a major concern for scientists today. Thymus caramanicus Jalas (Lamiaceae family) is one of the species of Thymus that grows wild in different regions of Iran. Traditionally, leaves of this plant are used in the treatment of diab...
Canu, Letizia;
Pradella, Silvia;
Rapizzi, Elena;
Fucci, Rossella;
Valeri, Andrea;
Briganti, Vittorio;
Giachè, Valentino;
Parenti, Gabriele;
Ercolino, Tonino;
Mannelli, Massimo.
SUMMARY Metastatic pheochromocytomas (PHEOs) and paragangliomas (sPGLs) are rare neural crest-derived tumors with a poor prognosis. About 50% of them are due to germ-line mutations of the SDHB gene. At present, there is no cure for these tumors. Their therapy is palliative and represented by different op...
Inhibidores de la Angiogénesis/uso terapéutico,
Antineoplásicos/uso terapéutico,
Indoles/uso terapéutico,
Mutación/genética,
Metástasis de la Neoplasia,
Paraganglioma/irrigación sanguínea,
Paraganglioma/tratamiento farmacológico,
Paraganglioma/genética,
Pirroles/uso terapéutico,
Succinato Deshidrogenasa/genética,
Sunitinib,
Resultado del Tratamiento
ABSTRACT Radioiodine (RAI)-refractory thyroid cancer is an uncommon entity, occurring with an estimated incidence of 4-5 cases/year/million people. RAI refractoriness is more frequent in older patients, in those with large metastases, in poorly differentiated thyroid cancer, and in those tumors with high...
ABSTRACT Hand-foot syndrome is a common cutaneous adverse effect associated with certain systemic chemotherapy drugs. It is characterized by erythema, edema, and burning sensation, especially over palmoplantar surfaces. We report the case of an elderly patient undergoing chemotherapy after a breast cance...
Abstract: Introduction and aims. Cholangiocarcinomas are a heterogeneous group of tumors that can be classified into three clinically distinct types of cancers, intrahepatic, perihilar and distal cholangiocarcinoma. The inconsistent use of nomenclature for these cancers has obscured a true knowledge of...
Antineoplásicos/uso terapéutico,
Neoplasias de los Conductos Biliares/terapia,
Procedimientos Quirúrgicos del Sistema Biliar,
Colangiocarcinoma/terapia,
Tumor de Klatskin/terapia,
Antineoplásicos/efectos adversos,
Neoplasias de los Conductos Biliares/clasificación,
Neoplasias de los Conductos Biliares/mortalidad,
Neoplasias de los Conductos Biliares/patología,
Procedimientos Quirúrgicos del Sistema Biliar/efectos adversos,
Procedimientos Quirúrgicos del Sistema Biliar/mortalidad,
Quimioterapia Adyuvante,
Colangiocarcinoma/clasificación,
Colangiocarcinoma/mortalidad,
Colangiocarcinoma/patología,
Florida,
Estimación de Kaplan-Meier,
Tumor de Klatskin/clasificación,
Tumor de Klatskin/mortalidad,
Tumor de Klatskin/patología,
Estadificación de Neoplasias,
Radioterapia Adyuvante,
Sistema de Registros,
Estudios Retrospectivos,
Factores de Tiempo,
Resultado del Tratamiento
