O Diabetes Mellitus é uma desordem sistêmica que afeta a produção de insulina excretada pelo pâncreas e desencadeia uma série de eventos de resposta imunológica do hospedeiro fazendo com que ocorra uma alteração nos tecidos periodontais. A doença periodontal é uma desordem inflamatória que at...
Hearing loss induced by chemotherapy and acoustic trauma is mainly associated with two factors, free radical formation and apoptosis pathway activation. Despite numerous efforts on reducing the effects of these factors, no definite strategy is still determined to interfere with and control these processe...
Abstract Objective The aim of this study was to evaluate the effects of gliclazide on oxidative stress, inflammation, and bone loss in an experimental periodontal disease model. Material and Methods Male albino Wistar rats were divided into no ligature, ligature, and ligature with 1, 5, and 10 mg/kg ...
Pérdida de Hueso Alveolar/tratamiento farmacológico,
Pérdida de Hueso Alveolar/patología,
Antioxidantes/farmacología,
Antioxidantes/uso terapéutico,
Catepsina K/análisis,
Técnica del Anticuerpo Fluorescente,
Encía/química,
Encía/patología,
Gliclazida/farmacología,
Gliclazida/uso terapéutico,
Glutatión/análisis,
Inmunohistoquímica,
Interleucina-1beta/análisis,
Factores Inhibidores de la Migración de Macrófagos/efectos adversos,
Malondialdehído/análisis,
Metaloproteinasa 2 de la Matriz/análisis,
Neutrófilos/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Periodontitis/tratamiento farmacológico,
Periodontitis/patología,
Peroxidasa/análisis,
Ligando RANK/análisis,
Distribución Aleatoria,
Ratas Wistar,
Receptor Activador del Factor Nuclear kappa-B/análisis,
Reproducibilidad de los Resultados,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factor de Necrosis Tumoral alfa/análisis,
Microtomografía por Rayos X
BACKGROUND: Tumourigenic cells modify metabolic pathways In order to facilitate increased proliferation and cell survival resulting in glucose-and glutamine addiction. Previous research indicated that glutamine deprivation resulted in potential differential activity targeting tumourigenic cells more prom...
Neoplasias de la Mama/patología,
Glutamina/deficiencia,
Especies Reactivas de Oxígeno/metabolismo,
Proliferación Celular,
Supervivencia Celular,
Estrés Oxidativo,
Neoplasias de la Mama/metabolismo,
Glutamina/metabolismo,
Apoptosis,
Línea Celular Tumoral,
Espectrofotometría
Abstract Aim: The present study aimed to analyze the effects of N-acetylcysteine supplementation associated with concurrent training on the bone mineral density of spontaneously hypertensive elderly rats. Methods: For the present study, 28 male spontaneously hypertensive rats, six months old, were di...
Abstract Aim SLE is a systemic autoimmune disease generally affecting woman in the reproductive age. It is associated with an altered level of Tregs and oxidative stress while an increase in Tregs, and different antioxidant mechanisms to combat oxidative stress are essential for successful pregnancy. H...
Lupus Eritematoso Sistémico/inmunología,
Lupus Eritematoso Sistémico/metabolismo,
Estrés Oxidativo,
Complicaciones del Embarazo/inmunología,
Complicaciones del Embarazo/metabolismo,
Linfocitos T Reguladores/citología,
Proteínas Sanguíneas/análisis,
Recuento de Linfocito CD4,
Linfocitos T CD4-Positivos,
Linfocitos T CD8-positivos,
Estudios de Casos y Controles,
CatalasaSangre,
Glutatión PeroxidasaSangre,
Inmunofenotipificación,
Peroxidación de Lípido,
Superóxido DismutasaSangre,
Linfocitos T Reguladores/inmunología
ABSTRACT OBJETIVE: to evaluate oxidative stress and non-enzymatic antioxidant defenses in informal caregivers, and correlations with anxiety, health satisfaction and quality of life. METHOD: a case-control analytical study was performed, where the case was represented by the main informal caregiver and ...
Objetivo: analisar pesquisas acerca da suplementação com ácidos graxos poliinsaturados ômega-3 (AGPI-n3) em praticantes de exercícios físicos intensos (EFI). Método: Para a realização do estudo, foram consultados artigos disponíveis nas seguintes bases de dados eletrônicas: Scielo, PubMed, Lil...
ABSTRACT Objective: To compare the effects that prone and supine positioning during high-frequency oscillatory ventilation (HFOV) have on oxygenation and lung inflammation, histological injury, and oxidative stress in a rabbit model of acute lung injury (ALI). Methods: Thirty male Norfolk white rabbits...
Lesión Pulmonar Aguda/patología,
Lesión Pulmonar Aguda/prevención & control,
Líquido del Lavado Bronquioalveolar/química,
Ventilación de Alta Frecuencia/efectos adversos,
Ventilación de Alta Frecuencia/métodos,
Peroxidación de Lípido,
Modelos Animales,
Estrés Oxidativo,
Oxígeno/metabolismo,
Posición Prona/fisiología,
Estudios Prospectivos,
Valores de Referencia,
Reproducibilidad de los Resultados,
Posición Supina/fisiología,
Factores de Tiempo,
Factor de Necrosis Tumoral alfa/análisis
Aim: Determine the relationship between changes in oxidative stress markers, muscle damage, DOMS, and their relationship with performance in response to a session of football training during a 1-week recovery period of young football players. Methods: Nineteen young football players aged 16.7±1.0 yea...
