Atualmente, está bem estabelecido que o ambiente fetal está ligado à saúde materna, e estímulos ou agressões anormais durante a vida intra-uterina podem resultar em mudanças na fisiologia e metabolismo da prole, aumentando o risco de doenças na vida adulta. Tal fenômeno é conhecido como program...
Barbosa, S C M;
Pereira, V B M;
Wong, D V T;
Santana, A P M;
Lucetti, L T;
Carvalho, L L;
Barbosa, C R N;
Callado, R B;
Silva, C A A;
Lopes, C D H;
Brito, G A C;
Alencar, N M N;
Lima-Júnior, R C P.
Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable. Amifostine is a cytoprotective agent with a described anti...
Amifostina/uso terapéutico,
Cricetinae,
Modelos Animales de Enfermedad,
Fluorouracilo/efectos adversos,
Inflamación/inducido químicamente,
Inflamación/patología,
Inflamación/prevención & control,
Sustancias Protectoras/uso terapéutico,
Estomatitis/inducido químicamente,
Estomatitis/patología,
Estomatitis/prevención & control,
Xerostomía/inducido químicamente,
Xerostomía/patología,
Xerostomía/prevención & control
The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation. A pre-clinical, prospective, and randomized experimental study of quantitative and...
Administración Tópica,
Analgésicos/administración & dosificación,
Antiinflamatorios/administración & dosificación,
Antiinflamatorios no Esteroideos/administración & dosificación,
Diclofenaco/administración & dosificación,
Modelos Animales de Enfermedad,
Inflamación/tratamiento farmacológico,
Inflamación/patología,
Inflamación/fisiopatología,
Fonoforesis,
Estudios Prospectivos,
Distribución Aleatoria,
Ratas Wistar,
Factor de Necrosis Tumoral alfa,
Terapia por Ultrasonido/métodos
Acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by a complex pathophysiology, involving not only the respiratory system but also nonpulmonary distal organs. Although advances in the management of ARDS have led to a distinct improvement in ARDS-related mortality, ARD...
ABSTRACT Objective: To compare the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as possible parameters of systemic inflammation in hyperglycemic and normoglycemic subjects. Methods: A retrospective, cross-sectional study of data collected from patients tested for fasting blood glucose, gl...
Glucemia/análisis,
Plaquetas,
Estudios de Casos y Controles,
Estudios Transversales,
Ayuno/sangre,
Hemoglobina Glucada/análisis,
Hiperglucemia/sangre,
Inflamación/sangre,
Recuento de Linfocitos,
Linfocitos,
Persona de Mediana Edad,
Neutrófilos,
Recuento de Plaquetas,
Valores de Referencia,
Estudios Retrospectivos,
Estadísticas no Paramétricas
Background: diabetes and periodontitis are common comorbidities; however, the clinical implications of this association remain only partially known. This study was aimed to characterize the periodontal status of type 2 diabetic (T2D) patients and its correlation with metabolic and inflammatory parameters...
RESUMO Objetivo: avaliar o impacto da hanseníase na qualidade de vida de pacientes com reações hansênicas. Método: estudo transversal e quantitativo realizado com 40 pacientes em janeiro de 2017 em ambulatório de hospital paraibano de referência utilizando questionário contendo dados sociodemog...
Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondrocytes in the presence of inflammatory factors have never been shown. Increased levels of pro-inflammatory cytokines are generally associated with the degradation and death o...
Agrecanos/metabolismo,
Supervivencia Celular/efectos de los fármacos,
Condrocitos/citología,
Condrocitos/efectos de los fármacos,
Condrocitos/metabolismo,
Ciclooxigenasa 2/metabolismo,
Dinoprostona/metabolismo,
Ginsenósidos/metabolismo,
Ginsenósidos/farmacología,
Inflamación/metabolismo,
Proteína Accesoria del Receptor de Interleucina-1/metabolismo,
Interleucina-1beta/efectos de los fármacos,
Interleucina-1beta/metabolismo,
Degeneración del Disco Intervertebral/metabolismo,
Dolor de la Región Lumbar/metabolismo,
Óxido Nítrico Sintasa/metabolismo,
Núcleo Pulposo/citología,
Núcleo Pulposo/efectos de los fármacos,
Núcleo Pulposo/metabolismo,
Factor de Necrosis Tumoral alfa/metabolismo,
Ubiquitinación
Abstract Clinical research has shed the light on the relation between coagulation and inflammation. Coagulation cascade is activated in lung injury resulting in thrombotic and fibrotic lesions. Such a cascade is initiated by inflammation, then the two systems intense each other. New therapies that modula...
Abstract The aim of this study was to evaluate the immunoexpression of human leukocyte antigen-DR (HLA-DR) in actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), and to correlate the findings with clinical (tumor size/extent, regional lymph node metastasis, and clinical stage) and histo...
Carcinogénesis/inmunología,
Queilitis/inmunología,
Queilitis/patología,
Antígenos HLA-DR/inmunología,
Inflamación/patología,
Neoplasias de los Labios/inmunología,
Neoplasias de los Labios/patología,
Neoplasias de los Labios/secundario,
Metástasis Linfática/patología,
Persona de Mediana Edad,
Clasificación del Tumor,
Carcinoma de Células Escamosas de Cabeza y Cuello/inmunología,
Carcinoma de Células Escamosas de Cabeza y Cuello/patología,
Carcinoma de Células Escamosas de Cabeza y Cuello/secundario,
Estadificación de Neoplasias
