Background Triterpenoids are multifunctional secondary metabolites in plants. But little information is available concerning the actual yield, optimal extraction method and pharmacologic activity with regard to triterpenoids from Jatropha curcas leaves (TJL). Hence, response surface methodology (RSM) was...
Jatropha/química,
Triterpenos/análisis,
Triterpenos/farmacología,
Antiinfecciosos/farmacología,
Antiinflamatorios/farmacología,
Depuradores de Radicales Libres,
Ultrasonido,
Etanol/análisis,
Factores de Tiempo,
Bacterias/efectos de los fármacos,
Hongos/efectos de los fármacos
Bovine viral diarrhea virus (BVDV) is an important cause of economic losses worldwide. E2 is an immunodominant protein and a promising candidate to develop subunit vaccines. To improve its immunogenicity, a truncated E2 (tE2) was fused to a single chain antibody named APCH, which targets to antigen-prese...
Community-acquired methicillin-resistant Staphylococcus aureus is the first cause of skin and soft tissue infections, but can also produce severe diseases such as bacteremia, osteomyelitis and necrotizing pneumonia. Some S. aureus lineages have been described in cases of necrotizing pneumonia worldwide, ...
As tiazolidinodionas (TZDs) são sensibilizadores de insulina utilizados no tratamento do diabetes mellitus tipo 2. Contudo, apesar dos efeitos benéficos sobre a glicemia, importantes efeitos adversos incluindo perda óssea e aumento de adiposidade são relatados com o uso clínico das TZDs. Assim, é n...
Feijó, J O;
Schneider, A;
Schmitt, E;
Brauner, C C;
Martins, C F;
Barbosa-Ferreira, M;
Del Pino, F A B;
Faria Junior, S P;
Rabassa, V R;
Corrêa, M N.
The aim of this study was to determine the effect of prepartum rbST injection on the metabolic profile of pregnant ewes induced to subclinical ketosis, as well as the metabolism until seven days of life and weight gain until seven weeks of life of the lambs. Twenty seven pregnant ewes of the pantaneiro g...
BACKGROUND: The purpose of the study was to compare the neurotoxic effects of intrathecally administered levobupivacaine, fentanyl and their mixture on rat spinal cord. METHODS: In experiment, there were four groups with medication and a control group. Rats were injected 15 µL saline or fentanyl 0.0005 ...
Souza, Thiago Moreno Lopes e;
Fintelman-Rodrigues, Natalia;
Resende, Paola Cristina;
Mesquita, Milene;
Gregianini, Tatiana Schaffer;
Bozza, Fernando A;
Pecego, Ana Carla;
Fernandes, Sandra Bianchini;
Cury, Ana Luisa Furtado;
Riediger, Irina Nastassja;
Siqueira, Marilda M.
The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have been f...
Procedimentos cirúrgicos oftalmológicos são realizados, em sua maioria, em pacientes com idade avançada e que apresentam diversas comorbidades clínicas, trazendo subsequentes preocupações com o emprego de anestesia geral. Há, portanto, preferência pela anestesia regional, sendo o bloqueio peribu...
Estudos apontam que a região Amazônica apresenta concentrações significativas de selênio nos solos e que, por isso, a população não estaria susceptível à deficiência desse mineral. Em contrapartida, a região também apresenta dados de concentrações elevadas de mercúrio nos solos e rios, en...
