SUMMARY: Diabetes and hypertension account for the majority of chronic kidney injury cases that can lead to renal failure. The link between the leukocytes common antigen (CD45) and diabetic kidney disease (DKD) with and without metformin incorporation in an animal model has not been investigated before. ...
Diabetes Mellitus,
Metformina/administración & dosificación,
Metformina/uso terapéutico,
Hipoglucemiantes/administración & dosificación,
Hipoglucemiantes/uso terapéutico,
Lesión Renal Aguda/prevención & control,
Inflamación,
Modelos Animales de Enfermedad,
Biomarcadores,
Estrés Oxidativo/efectos de los fármacos,
Antígenos Comunes de Leucocito,
Riñón/efectos de los fármacos
SUMMARY: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) represent a unique class of glucose-declining renal-targeted drugs. The SGLT2i Canagliflozin (CANA) is an anti-hyperglycemic drug that reduces various cardiovascular and renal outcomes in patients with type 2 diabetes mellitus. This study aimed ...
SUMMARY: In Saudi Arabia, it is widely believed that women with reproductive problems can use the extract of the sage plant as a tea drink. This study was conducted to investigate the effects of this herb on the fertility of female rats and embryo implantation. Forty-eight Wistar virgin female rats were ...
SUMMARY: Di-(2-ethylhexyl) phthalate (DEHP) is among the most common plasticizer additives that humans are in contact with daily. DEHP can be released from plastic and enter the human body, whereby it is metabolized and transformed into oxidative hydrophilic molecules. Clinical follow-ups in patients exp...
SUMMARY: Statins inhibit cholesterol synthesis, but also have other pleiotropic effects. There are indications that they affect macrophage survival trough the regulation of apoptosis. We analyzed 50 samples of aortic wall, selected based on statins in patients' therapy (n=25, Th-S group) or statin-free t...
Inhibidores de Hidroximetilglutaril-CoA Reductasas/administración & dosificación,
Aterosclerosis/metabolismo,
Apoptosis/efectos de los fármacos,
Proteína bcl-X/metabolismo,
Genes bcl-2/fisiología,
Macrófagos/efectos de los fármacos,
Aorta/efectos de los fármacos,
Aterosclerosis/tratamiento farmacológico,
Placa Aterosclerótica,
Factores de Riesgo,
Medición de Riesgo
SUMMARY: Ingestion of an overdose of paracetamol (also called acetaminophen, or APAP) induces hepatotoxicity that can lead to liver failure. The link between the pro-inflammatory microRNA-155 (miR-155) and leukocyte infiltration (CD45) in APAP- antioxidant depletion and liver toxicity with and without th...
RESUMEN: Las bacteriocinas son péptidos antimicrobianos de síntesis ribosomal secretadas por bacterias. Dentro de estas destaca nisina que posee potenciales usos en terapias antibióticas, como biopreservante de alimentos y probióticos. También se ha descrito que nisina posee citotoxicidad sobre lín...
SUMMARY: Ischemia-reperfusion (I/R) of the small intestine causes serious abdominal pathologies including tissue dysfunction and organ failure. L-carnitine (L-C), a powerful antioxidant, may help lessen the severity of these pathological effects since it plays a key role in energy metabolism. In this wor...
SUMMARY: Letrozole is mainly used for the treatment of unexplained infertility, breast cancer and polycystic ovarian syndrome, with secondary use in ovarian stimulation. In cases of unexpected or unknown pregnancy during the use of letrozole, letrozole may cause a teratogenic effect on the fetus. In this...
Desarrollo Óseo/efectos de los fármacos,
Osteogénesis/efectos de los fármacos,
Teratógenos/farmacología,
Letrozol/farmacología,
Letrozol/efectos adversos,
Antineoplásicos/farmacología,
Antineoplásicos/efectos adversos,
Inmunohistoquímica,
Ratas Wistar,
Coloración y Etiquetado/métodos,
Desarrollo Fetal/efectos de los fármacos
SUMMARY: Peripheral nerve damage (PNI) can cause demyelination, axonal degeneration and loss of motor and sensory function. Melatonin with its antioxidative effect, has been reported to reduce scar formation in nerve injury, take a role in repair process by suppressing fibroblast proliferation in the dam...
Tibia/patología,
Enfermedades del Sistema Nervioso Periférico/tratamiento farmacológico,
Tibia/inervación,
Melatonina/administración & dosificación,
Antioxidantes/administración & dosificación,
Modelos Animales de Enfermedad,
Ratas Wistar,
Proteínas S100,
Factor A de Crecimiento Endotelial Vascular,
Nervios Periféricos/efectos de los fármacos,
Fibroblastos
