Abstract Purpose: To evaluate the in vivo response of photobiomodulation therapy associated with norbixin-based poly(hydroxybutyrate) membrane (PHB) in tenotomized calcaneal tendon. Methods: Thirty rats were randomly allocated to six groups (n=5 each): LED groups (L1, L2 and L3) and membrane + LED grou...
Tendón Calcáneo/efectos de los fármacos,
Tendón Calcáneo/efectos de la radiación,
Tendón Calcáneo/cirugía,
Carotenoides/farmacología,
Colágeno/farmacología,
Colágeno Tipo I/análisis,
Colágeno Tipo I/efectos de los fármacos,
Colágeno Tipo III/análisis,
Colágeno Tipo III/efectos de los fármacos,
Evaluación Preclínica de Medicamentos,
Fibroblastos/química,
Fibroblastos/efectos de los fármacos,
Hidroxibutiratos/farmacología,
Terapia por Luz de Baja Intensidad/métodos,
Prohibitinas,
Distribución Aleatoria,
Ratas Wistar,
Tendinopatía/radioterapia,
Tenotomía/métodos,
Cicatrización de Heridas/efectos de los fármacos,
Cicatrización de Heridas/efectos de la radiación
Abstract Purpose: To evaluate the healing potential of the electrospinning membranes of Poly (Lactic Acid) (PLA) associated with Sedum dendroideum extract in burn injuries in rats. Methods: Seventy-five rats were submitted to burn injury on their back skin: (C) untreated; (F) with daily topical applica...
Abstract Purpose: To analyze the serum levels of nitric oxide and correlate them with the levels of thiobarbituric acid reactive substances (TBARS) in liver, brain and spinal cord of animals using L-NAME and treated with hydroxyurea. Methods: Eighteen male albino Wistar rats were divided into three gro...
Anemia de Células Falciformes/tratamiento farmacológico,
Anemia de Células Falciformes/metabolismo,
Anemia de Células Falciformes/fisiopatología,
Encéfalo/metabolismo,
Modelos Animales de Enfermedad,
Hidroxiurea/uso terapéutico,
Hígado/metabolismo,
NG-Nitroarginina Metil Éster,
Estrés Oxidativo/fisiología,
Ratas Wistar,
Médula Espinal/metabolismo
Meirelles, Rogério José de Azevedo;
Lizarte Neto, Fermino Sanches;
Cirino, Mucio Luiz de Assis;
Novais, Paulo Cezar;
Gula, Isabella Stracieri;
Silva, Jairo Pinheiro da;
Tazzima, Maria de Fátima Galli Sorita;
Fazan, Valéria Paula Sassoli;
Durand, Marina Toledo;
Tirapelli, Daniela Pretti da Cunha;
Carvalho, Camila Albuquerque Melo de;
Schimming, Bruno César;
Molina, Carlos Augusto Fernandes;
Tucci Junior, Silvio;
Tirapelli, Luis Fernando.
Abstract Purpose To evaluate the effect of chronic alcoholism on morphometry and apoptosis mechanism and correlate with miRNA-21 expression in the corpus cavernosum of rats. Methods Twenty-four rats were divided into two experimental groups: Control (C) and Alcoholic group (A). After two weeks of an ...
Alcoholismo/complicaciones,
Apoptosis/efectos de los fármacos,
Caspasa 3/análisis,
Modelos Animales de Enfermedad,
Disfunción Eréctil/inducido químicamente,
Disfunción Eréctil/patología,
Expresión Génica,
Inmunohistoquímica,
MicroARNs/análisis,
Músculo Liso/efectos de los fármacos,
Pene/efectos de los fármacos,
Pene/patología,
Ratas Wistar,
Valores de Referencia
Abstract Purpose To investigate the effects of bradykinin on reperfusion injury in an experimental intestinal ischemia reperfusion model. Methods We used 32 Wistar-Albino rats. We composed 4 groups each containing 8 rats. Rats in sham group were sacrified at 100 minutes observation after laparotomy. ...
Bradiquinina/farmacología,
Modelos Animales de Enfermedad,
Intestino Delgado/efectos de los fármacos,
Precondicionamiento Isquémico/métodos,
Laparotomía,
Peroxidasa/análisis,
Distribución Aleatoria,
Ratas Wistar,
Valores de Referencia,
Daño por Reperfusión/prevención & control,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento,
Vasodilatadores/farmacología
Abstract Purpose To evaluate the effect of N-Acetylcysteine (NAC) in newborn rats submitted to hypoxia and reoxygenation (H/R) conditions in an experimental model of necrotizing enterocolitis. Methods Eight pregnant rats and their 70 cubs were used (5 groups) and exposed to H/R conditions and receive...
Acetilcisteína/farmacología,
Modelos Animales de Enfermedad,
Enterocolitis Necrotizante/prevención & control,
Hipoxia/patología,
Íleon/efectos de los fármacos,
Íleon/patología,
Sustancias Protectoras/farmacología,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento
Abstract Purpose To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions. Methods The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XR...
Abstract Purpose 5-flourourasil (5-FU) is commonly used for early intraperitoneal chemotherapy in colorectal or appendiceal cancer patients with peritoneal carcinomatosis. Due to its effect, anastomosis healing can be impaired and leads to anastomotic leakage. In this study, we aimed to investigate the...
Abstract Purpose The objective of this study was to investigate the accuracy of 18F-FDG-PET in the diagnosis of multibacterial abdominal sepsis by cecum ligation and puncture (CLP) in rats. Methods Adult Wistar rats ( Rattus norvegicus ), weighing 227±35g, were allocated into a sepsis group by CLP (...
Fluorodesoxiglucosa F18,
Infecciones Intraabdominales/diagnóstico por imagen,
Infecciones Intraabdominales/patología,
Tomografía de Emisión de Positrones/métodos,
Valor Predictivo de las Pruebas,
Radiofármacos,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Sepsis/diagnóstico por imagen,
Sepsis/patología,
Factores de Tiempo
Abstract Purpose To determine by histomorphometric analysis whether CO2 pneumoperitoneum interferes with collagen deposition in surgical wounds in the aponeurosis of rats. Methods This experiment involved 80 male Wistar rats, randomly allocated into four groups according to pneumoperitoneum period (P...
