Ferreira, Magda Rhayanny Assunção;
Santiago, Rosilene Rodrigues;
Silva-Rocha, Walicyranison Plínio;
Souza, Luanda Barbara Ferreira Canário de;
Faria, Maria Graciela Icher;
Mello, João Carlos Palazzo de;
Langassner, Silvana Maria Zucolotto;
Chaves, Guilherme Maranhão;
Milan, Eveline Pipolo;
Svidzinski, Terezinha Inez Estivalet;
Soares, Luiz Alberto Lira.
The aim of this study was evaluate the in vitro antifungal activity of crude extracts from Eugenia uniflora, Libidibia ferrea and Psidium guajava. The extracts were obtained by turbo-extraction using water (AQ) or acetone-water (AC-W) (7:3, v/v) as solvents and lyophilized to obtain the crude extracts (C...
A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diamete...
Gold coated magnetite nanoparticles were prepared and coated with ranibizumab as an ocular drug delivery system. The surface morphologies of the nanoparticles were determined by Scanning Electron Microscopy (SEM). The size and surface charge were determined by using the dynamic light scattering (DLS) tec...
Técnicas In Vitro/instrumentación,
Nanopartículas de Magnetita/administración & dosificación,
Ranibizumab/efectos adversos,
Microscopía Electrónica de Rastreo/métodos,
Análisis Espectral/instrumentación,
Dispersión Dinámica de Luz/instrumentación,
Ensayo de Inmunoadsorción Enzimática/instrumentación,
Métodos,
Oro,
Rayos X,
Sistemas de Liberación de Medicamentos
The aim of the present study was to enhance the dissolution rate of an NSAID drug Ketoprofen by formulating it into solid dispersions with water soluble carrier Poloxamer 188 and Eudragit S 100. The solid dispersions of Ketoprofen with Poloxamer 188 were prepared at 1:1, 1:1.5 and 1:2 (Ketoprofen: Poloxa...
This study aims to investigate chemical composition of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits and determine their in vitro antibacterial activity. Essential oils were extracted by hydrodistillation from Murraya paniculata (L.) Jack ripe and unripe fruits collec...
Aceites Volátiles/química,
Técnicas In Vitro/métodos,
Frutas/anatomía & histología,
Cromatografía de Gases y Espectrometría de Masas/métodos,
Cromatografía de Gases/instrumentación,
Murraya/clasificación,
Mycobacterium/clasificación,
Mycobacterium kansasii,
Rutaceae/anatomía & histología,
Streptococcus mutans,
Pruebas de Sensibilidad Microbiana
The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were...
Oral fast-dispersible film was prepared by utlizing donepezil hydrochloride (drug) and various cellulose derivatives such as hydroxypropyl methyl cellulose (hypermellose) (HPMC), microcrystalline cellulose (MCC) and nanocrystalline cellulose (NCC) to treat Alzheimer's disease. NCC was synthesized by ultr...
Antimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic s...
Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mic...
Hypericum sinaicum L. is an endangered Egyptian medicinal plant of high importance due to the presence of naphthodianthrones (hypericins), which have photodynamic properties and pharmaceutical potential. We sought to assess H. sinaicum ability to develop hairy roots that could be cultured in contained co...
