Abstract: Porphyria cutanea tarda has a complex etiology with genetic factors not completely elucidated. The miscegenation of the Brazilian population has important implications in the predisposition to diseases. There are no studies concerning the genetic ancestry of patients with porphyria cutanea tard...
Abstract: Background: The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results. Objective: The aim here was to assess the association between GSTM1/T1 null polymorphisms and ...
ABSTRACT Objective Monocyte chemoattractant protein 1 (MCP-1) has been suggested to be involved in the pathophysiology of insulin resistance (IR); therefore, variants in the MCP-1 gene may contribute to the development of this disease. The aim of this study was to analyze the relationship of the -2518 A...
ABSTRACT Objectives This study aimed to evaluate the frequencies of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) and methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphisms in obese patients with and without type 2 diabetes mellitus (T2DM). Subjects and methods The...
Brasil,
Estudios de Casos y Controles,
Diabetes Mellitus Tipo 2/complicaciones,
Diabetes Mellitus Tipo 2/enzimología,
Diabetes Mellitus Tipo 2/genética,
Eliminación de Gen,
Predisposición Genética a la Enfermedad,
Genotipo,
Metilenotetrahidrofolato Reductasa (NADPH2)/genética,
Mutagénesis Insercional,
Obesidad/complicaciones,
Obesidad/enzimología,
Peptidil-Dipeptidasa A/genética,
Reacción en Cadena de la Polimerasa,
Polimorfismo Genético/genética,
Factores de Riesgo
Using a metagenomic approach, we identified hepatitis A virus among cases of acute febrile illnesses that occurred in 2008-2012 in Brazil suspected as yellow fever. These findings reinforce the challenge facing routine clinical diagnosis in complex epidemiological scenarios....
Abstract Background: Metabolic syndrome (MS) is a condition that, when associated with ischemic heart disease and cardiovascular events, can be influenced by genetic variants and determine more severe coronary atherosclerosis. Objectives: To examine the contribution of genetic polymorphisms to the exte...
Histopathological evaluation of liver from 33 pigs slaughtered for human consumption in Amazon region, previously tested by serology and molecular techniques for hepatitis E virus infection (HEV), was analysed in three groups: Group 1, negative for both HEV-RNA and anti-HEV IgG (n=10); Group 2, positive ...
Cavalcante, José Roosevelt;
Pinheiro, Luiz Gonzaga Porto;
Almeida, Paulo Roberto Carvalho de;
Ferreira, Márcia Valéria Pitombeira;
Cruz, Gizele Almada;
Campelo, Thales Alves;
Silva, Caroliny Soares;
Lima, Luana Nepomuceno Gondim Costa;
Oliveira, Bruno Masato Kitagawa de;
Lima, Lara Mulato;
Feitosa, Laura Magda Costa;
Pinheiro, Agostinho Câmara;
Frota, Cristiane Cunha.
OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the non-ma...
OBJECTIVES: To study the relationship between the Asp1104His polymorphism of the nucleotide excision repair gene ERCC5 and treatment sensitivity to oxaliplatin in patients with advanced colorectal cancer (CRC) in China. METHODS: A group of 226 patients in the Department of Gastrointestinal Oncology at Z...
Antineoplásicos/uso terapéutico,
Estudios de Casos y Controles,
Neoplasias Colorrectales/tratamiento farmacológico,
Neoplasias Colorrectales/genética,
Neoplasias Colorrectales/mortalidad,
Proteínas de Unión al ADN/genética,
Endonucleasas/genética,
Genotipo,
Estimación de Kaplan-Meier,
Estadificación de Neoplasias,
Proteínas Nucleares/genética,
Oxaliplatino/uso terapéutico,
Polimorfismo de Nucleótido Simple/genética,
Factores de Transcripción/genética
