A periodontite é uma doença inflamatória crônica, multifatorial, associada com a
disbiose do biofilme dental e caracterizada pela destruição dos tecidos de suportes
dos dentes. Embora a presença das bactérias seja essencial na patogênese da
periodontite, fatores do hospedeiro, como os genéticos...
A lesão inflamatória de origem periférica aumenta a sensibilidade sensória a um estímulo mecânico de leve intensidade, provocando dor, um processo conhecido como alodinia. A recente descoberta de que astrócitos e micróglia da medula espinal tornam-se reativos devido à inflamação periférica, s...
The thiazolidinediones (TZDs) class comprises drugs with hypoglycemic effects, reducing insulin resistance in peripheral tissues. Our group has demonstrated in preliminary in vivo studies that a new TZD, GQ-11, improves insulin resistance as well as modulates cytokines involved in inflammatory process, s...
Himatanthus drasticus (Mart.) Plumel belongs to the Apocynaceae family and the latex from its trunk bark (Hd) is known as "janaguba milk". This latex is widely used in Northeast Brazil, mainly in the Cariri region, for its gastroprotective, anti-inflammatory, and antitumor properties. The objective of th...
Analgésicos/uso terapéutico,
Antiinflamatorios/uso terapéutico,
Apocynaceae/química,
Biomarcadores/sangre,
Modelos Animales de Enfermedad,
Edema/tratamiento farmacológico,
Inmunohistoquímica,
Inflamación/tratamiento farmacológico,
Ratas Wistar,
Triterpenos/aislamiento & purificación,
Triterpenos/uso terapéutico
This study aimed to explore the influence of gut microbiota alterations induced by Linderae radix ethanol extract (LREE) on alcoholic liver disease (ALD) in rats and to study the anti-inflammatory effect of LREE on ALD through the lipopolysaccharide (LPS) toll-like receptor 4 (TLR4)-nuclear factor kappa ...
Citocinas/sangre,
Modelos Animales de Enfermedad,
Microbioma Gastrointestinal/efectos de los fármacos,
Inflamación/prevención & control,
Lindera/química,
Lipopolisacáridos/sangre,
Hígado/ultraestructura,
Hepatopatías Alcohólicas/diagnóstico por imagen,
Hepatopatías Alcohólicas/prevención & control,
Extractos Vegetales/farmacología,
Raíces de Plantas/química,
Proteínas Serina-Treonina Quinasas/sangre,
Ratas Sprague-Dawley,
Receptor Toll-Like 4/sangre
Excessive pro-inflammatory cytokines result in adverse pregnancy outcomes, including preeclampsia-like phenotypes, and fetal growth restriction. Anti-inflammation might be an effective therapy. The aim of this research was to investigate whether Uncaria rhynchophylla alkaloid extract (URE), a highly safe...
Abstract: This study evaluated the cytotoxicity and biocompatibility of a new bioceramic endodontic sealer (i.e., Sealer Plus BC) in comparison with those of MTA Fillapex and AH Plus. L929 fibroblasts were cultured and Alamar Blue was used to evaluate cell viability of diluted extracts (1:50, 1:100, and ...
Compuestos de Aluminio/química,
Materiales Biocompatibles,
Cementos para Huesos/química,
Cementos para Huesos/farmacología,
Cementos para Huesos/toxicidad,
Compuestos de Calcio/sangre,
Hidróxido de Calcio/química,
Hidróxido de Calcio/farmacología,
Hidróxido de Calcio/toxicidad,
Supervivencia Celular/efectos de los fármacos,
Células Cultivadas/efectos de los fármacos,
Cerámica/química,
Combinación de Medicamentos,
Resinas Epoxi/química,
Fibroblastos/efectos de los fármacos,
Técnicas In Vitro,
Inflamación,
Ensayo de Materiales,
Óxidos/química,
Ratas Wistar,
Materiales de Obturación del Conducto Radicular/química,
Materiales de Obturación del Conducto Radicular/toxicidad,
Silicatos/química,
Tejido Subcutáneo/patología
OBJECTIVES: We aimed to explore the effects of diet on the inflammatory response in middle-aged and elderly people with hypertension. METHODS: Thirty overweight or obese patients with stage one hypertension (age range, 45-75 years) were allocated to either the intervention or control group (n=15 per gro...
Adiponectina/sangre,
Biomarcadores/sangre,
Presión Sanguínea/efectos de los fármacos,
Proteína C-Reactiva/análisis,
China,
Suplementos Dietéticos/análisis,
Ingestión de Energía,
Hipertensión/sangre,
Inflamación/sangre,
Molécula 1 de Adhesión Intercelular/sangre,
FN-kappa B/sangre,
Encuestas Nutricionales/estadística & datos numéricos,
Sobrepeso/sangre,
Polvos/uso terapéutico,
Población Rural
OBJECTIVES: The inflammatory response is a key mechanism of neuronal damage and loss during acute ischemic stroke. Hypothermia has shown promise as a treatment for ischemic stroke. In this study, we investigated the molecular signaling pathways in ischemic stroke after hypothermia treatment. METHODS: Cy...
Enfermedad Aguda,
Biomarcadores/sangre,
Western Blotting,
Isquemia Encefálica/sangre,
Isquemia Encefálica/terapia,
Quinasa 5 Dependiente de la Ciclina/sangre,
Modelos Animales de Enfermedad,
Ensayo de Inmunoadsorción Enzimática,
Hipotermia Inducida/métodos,
Inflamación/sangre,
Interleucina-1beta/sangre,
FN-kappa B/sangre,
Ratas Sprague-Dawley,
Resultado del Tratamiento
RESUMEN OBJETIVO: Determinar el efecto del aceite de linaza sobre las concentraciones plasmáticas de resistina en mujeres con diagnóstico de síndrome de ovarios poliquísticos. METODOS: se realizó un estudio en 195 mujeres con diagnóstico de SOPQ que fueron tratadas con aceite de linaza por 12 sem...
