The membrane-based efflux pump systems are recognized to have an important role in pathogenicity and drug resistance in Mycobacterium tuberculosis by the extrusion of toxic substrates and drugs from the inner bacillus. This study aimed to investigate the in vitro interaction of Verapamil (VP), an efflux ...
This paper reports on the development of nanoparticles aiming at the in vitro controlled release of simvastatin (SVT). The nanoparticles were prepared by the nanoprecipitation method with polymers Eudragit® FS30D (EDGFS) or Eudragit® NE30D (EDGNE). EDGFS+SVT nanoparticles showed mean size of 148.8 nm a...
Temozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug was ...
Cavalcante, Géssica Soares;
Morais, Selene Maia de;
André, Weibson Paz Pinheiro;
Araújo-Filho, José Vilemar de;
Muniz, Celli Rodrigues;
Rocha, Letícia Oliveira da;
Ribeiro, Wesley Lyeverton Correia;
Rodrigues, Ana Livya Moreira;
Oliveira, Lorena Mayana Beserra de;
Bevilaqua, Claudia Maria Leal;
Ramos, Márcio Viana.
Abstract This study aimed to evaluate the anthelmintic and ultrastructural effects of Calotropis procera latex on Haemonchus contortus. C. procera latex was twice centrifuged at 10,000×g and dialyzed to obtain a fraction rich in proteins, named LP (latex protein), and at 3,000 rpm to obtain a fraction r...
Haemonchus/efectos de los fármacos,
Calotropis/química,
Látex/química,
Antihelmínticos/farmacología,
Haemonchus/ultraestructura,
Técnicas In Vitro,
Cromatografía Líquida de Alta Presión,
Enfermedades de las Ovejas/parasitología,
Resistencia a Medicamentos,
Ovinos/parasitología,
Hemoncosis/veterinaria,
Haemonchus/aislamiento & purificación,
Látex/aislamiento & purificación,
Haemonchus/fisiología,
Microscopía Electrónica de Rastreo,
Brasil,
Fenoles/química,
Taninos/química,
Antocianinas/química,
Fitosteroles/química,
Triterpenos/química,
Saponinas/química,
Alcaloides/química,
Cardenólidos/química
Docetaxel-loaded acetic acid conjugated Cordyceps sinensis polysaccharide (DTX-AA-CSP) nanoparticles were prepared through dialysis and their release rates in vitro, particle sizes, zeta potentials, drug loading capacities, and encapsulation efficiencies were characterized for the synthesis of AA-modifie...
Abstract Objective: To perform an in vivo evaluation on the agreement between measurements of working length obtained by conventional radiographic examinations and an apex locator in deciduous teeth with or without root resorption. Material and Methods: Nine canals of teeth from children ranging from 3...
La etnomedicina es una disciplina idónea para elegir especies vegetales con el fin de ser estudiadas farmacológicamente; las cuatro especies seleccionadas para el presente estudio se usan como hipoglucemiantes en la medicina tradicional de la Amazonía peruana. Objetivos. Estudiar la capacidad inhibito...
A técnica semidireta realizada com resina composta pode ser uma excelente opção de
tratamento para restaurações profundas e extensas em dentes posteriores devido às
dificuldades técnicas no uso da resina composta pela técnica direta, como também pelos
maiores custo e tempo de tratamento das rest...
Objetivo: Avaliar o efeito do tempo de exposição e do tipo de compósito na
produção de artefato radiográfico na interface dente/material restaurador. Materiais e
Métodos: Em 20 incisivos bovinos hígidos foram feitos preparos cavitários e
restaurações classe II utilizando resinas compostas Filt...
Introduction: Three vanadium complexes with orotic and glutamic acids, in their anion forms, were prepared and their in vitro cytotoxicity toward human lung fibroblasts (MRC-5), human hepatocellular carcinoma (HepG2) and human colorectal adenocarcinoma (Caco-2) are reported. Objective: Describe the synth...
Carcinoma Hepatocelular/tratamiento farmacológico,
Compuestos de Vanadio/farmacología,
Ensayos de Selección de Medicamentos Antitumorales,
Técnicas In Vitro,
Ácido Orótico/farmacología,
Ácido Glutámico/farmacología,
Fibroblastos Asociados al Cáncer/efectos de los fármacos,
Neoplasias Pulmonares/tratamiento farmacológico,
Adenocarcinoma/tratamiento farmacológico,
Neoplasias Colorrectales/tratamiento farmacológico,
Antineoplásicos/farmacología,
Línea Celular Tumoral/efectos de los fármacos
