ABSTRACT BACKGROUND: Approximately 50% of patients with newly diagnosed non-small cell lung cancer (NSCLC) are over 70 years of age at diagnosis. Despite this fact, these patients are underrepresented in randomized controlled trials (RCTs). As a consequence, the most appropriate regimens for these pati...
Antineoplásicos/efectos adversos,
Antineoplásicos/uso terapéutico,
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos,
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico,
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Carcinoma de Pulmón de Células no Pequeñas/mortalidad,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/mortalidad,
Estadificación de Neoplasias,
Compuestos de Platino/efectos adversos,
Compuestos de Platino/uso terapéutico,
Calidad de Vida,
Ensayos Clínicos Controlados Aleatorios como Asunto
Abstract Tyrosine kinase inhibitors are effective as a target therapy for malignant neoplasms. Imatinib was the first tyrosine kinase inhibitor used. After its introduction, several other drugs have appeared with a similar mechanism of action, but less prone to causing resistance. Even though these drugs...
Erupciones por Medicamentos/etiología,
Erupciones por Medicamentos/patología,
Liquen Plano/patología,
Inhibidores de Proteínas Quinasas/efectos adversos,
Pirimidinas/efectos adversos,
Alopecia/inducido químicamente,
Alopecia/patología,
Antineoplásicos/efectos adversos,
Biopsia,
Mesilato de Imatinib/efectos adversos,
Leucemia Mielógena Crónica BCR-ABL Positiva/tratamiento farmacológico
Summary This review is aimed at the systematic mapping of ascorbic acid in the prevention and/or treatment of cancer in clinical and non-clinical studies from 2011 to 2015, in order to understand dose-response variations as well as its mechanisms of action as an antioxidant and antitumor agent. Seventy-e...
Summary Objective: To compare nutritional risk in adult patients undergoing chemotherapy and radiotherapy in the beginning, middle, and end of oncologic treatment. Method: This prospective, comparative study included 83 adult patients, 44 undergoing chemotherapy (CT group) and 39 undergoing radiotherap...
Antineoplásicos/efectos adversos,
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/complicaciones,
Ingestión de Alimentos/efectos de los fármacos,
Desnutrición/etiología,
Persona de Mediana Edad,
Neoplasias/tratamiento farmacológico,
Neoplasias/radioterapia,
Evaluación Nutricional,
Estado Nutricional,
Estudios Prospectivos,
Radioterapia/efectos adversos,
Medición de Riesgo/métodos,
Factores de Riesgo,
Índice de Severidad de la Enfermedad,
Encuestas y Cuestionarios,
Factores de Tiempo,
Pérdida de Peso
ABSTRACT Objective: To implement a clinical pharmacy service focused on the comprehensive review of antineoplastic drugs used in therapy of hematological diseases. Methods: An interventional study was conducted in a Brazilian tertiary teaching hospital in two different periods, with and without a clini...
Introducción: la familia Leguminosae es rica en isoflavonoides y puede tener efecto anticáncer. Las especies panameñas de esta familia no han sido estudiadas para explorar su potencial en los cánceres de mamas y próstata, dos principales causas de mortalidad en la población adulta panameña. Objeti...
Torres, Orlando Jorge Martins;
Marques, Márcio Carmona;
Santos, Fabio Nasser;
Farias, Igor Correia de;
Coutinho, Anelisa Kruschewsky;
Oliveira, Cássio Virgílio Cavalcante de;
Kalil, Antonio Nocchi;
Mello, Celso Abdon Lopes de;
Kruger, Jaime Arthur Pirola;
Fernandes, Gustavo dos Santos;
Quireze Jr, Claudemiro;
Murad, André M;
Silva, Milton José de BARROS E;
Zurstrassen, Charles Edouard;
Freitas, Helano Carioca;
Cruz, Marcelo Rocha;
Weschenfelder, Rui;
Linhares, Marcelo Moura;
Castro, Leonaldson dos Santos;
Vollmer, Charles;
Dixon, Elijah;
Ribeiro, Héber Salvador de Castro;
Coimbra, Felipe José Fernandez.
ABSTRACT In the last module of this consensus, controversial topics were discussed. Management of the disease after progression during first line chemotherapy was the first discussion. Next, the benefits of liver resection in the presence of extra-hepatic disease were debated, as soon as, the best sequen...
INTRODUCCIÓN: Antecedentes: El Instituto de Evaluación de Tecnologías en Salud e Investigación (IETSI) ha recibido la solicitud de evaluar el uso e la seguridad y eficacia de sorafenib en el tratamiento de pacientes con diagnóstico de carcinoma de tiroides, metastásico, irresecable, refractario a t...
ABSTRACT Purpose: The aim of this study was to assess the impact of sunitinib treatment in a non-screened group of patients with metastatic renal cell cancer (mRCC) treated by the Brazilian Unified Health System (SUS) at a single reference institution. Material and Methods: Retrospective cohort study, ...
Antineoplásicos/efectos adversos,
Antineoplásicos/uso terapéutico,
Brasil,
Carcinoma de Células Renales/tratamiento farmacológico,
Carcinoma de Células Renales/secundario,
Supervivencia sin Enfermedad,
Programas de Gobierno,
Indoles/efectos adversos,
Indoles/uso terapéutico,
Neoplasias Renales/tratamiento farmacológico,
Neoplasias Renales/patología,
Neoplasias Pulmonares/secundario,
Metástasis Linfática,
Persona de Mediana Edad,
Programas Nacionales de Salud,
Pirroles/efectos adversos,
Pirroles/uso terapéutico,
Estudios Retrospectivos,
Sunitinib
Resumo Objetivo Descrever a frequência, características, localização, intensidade da dor em pacientes com câncer de mama em uso do quimioterápico Docetaxel. Métodos Estudo longitudinal realizado com 17 mulheres com câncer de mama em tratamento com Docetaxel. As pacientes foram avaliadas duran...
