La prevalencia de enfermedad renal ha aumentado considerablemente en la última década y está previsto que crezca en los próximos años. Recientemente, diversos modelos se han utilizado para entender los procesos fisiopatológicos de daño renal y para la búsqueda de futuros candidatos farmacológico...
Abstract Objective: To investigate the differences of receptor activator of nuclear factor-κB ligand (RANKL) and Osteoprotegerin (OPG) expressions between normoglycemic and hyperglycemic Wistar rats (Rattus Novergicus) during Orthodontic Tooth Movement (OTM). Material and Methods: This study was t...
Técnicas de Investigación,
Análisis de Varianza,
Ratas Wistar,
Técnicas de Movimiento Dental,
Osteoprotegerina,
Inmunohistoquímica,
Diente Molar,
28573,
Diabetes Mellitus,
Hiperglucemia,
Estreptozocina,
Ligando RANK
Resumo Contexto A isquemia e reperfusão (I/R) renal está envolvida diretamente com insuficiência renal aguda, ocorrendo em casos como infarto por embolização ou trombose, quadros de septicemia e transplante renal. Esse processo é complexo, envolvendo respostas imunes inatas e adaptativas, presenç...
28573,
Isquemia/complicaciones,
Reperfusión/métodos,
Riñón,
Insuficiencia Renal/terapia,
Soluciones Preservantes de Órganos/uso terapéutico,
Bicarbonato de Sodio,
Cloruro de Potasio,
Cloruro de Sodio,
Fosfatos,
Ratas Wistar
Abstract Purpose To evaluate the effects of treatment with Indigo Carmine (IC) on rat livers subjected to ischemia-reperfusion injury. Methods The animals were subdivided into 4 groups: 1.SHAM group(SH) - saline; 2.SHAM group with IC-2mg/Kg(SHIC); 3.IR group - rats submitted to ischemia and reperfusi...
Abstract Purpose: The current study explored the involvement of neurogenic pathway-linked cholecystokinin (CCK) release in RIP-induced cardioprotection in rats. Methods: Male Wistar rats were subjected to four cycles of alternate episodes of ischemia and reperfusion (five min each) to induce RIP. There...
Luchi, T C;
Coelho, P M;
Cordeiro, J P;
Assis, A L E M;
Nogueira, B V;
Marques, V B;
dos Santos, L;
Lima-Leopoldo, A P;
Lunz, W;
Leopoldo, A S.
Nitric oxide (NO) inhibition by high-dose NG-nitro-L-arginine methyl ester (L-NAME) is associated with several detrimental effects on the cardiovascular system. However, low-dose L-NAME increases NO synthesis, which in turn induces physiological cardiovascular benefits, probably by activating a protectiv...
Adiposidad,
Peso Corporal/fisiología,
Calcio/análisis,
Inhibidores Enzimáticos/administración & dosificación,
Inhibidores Enzimáticos/farmacología,
Hemodinámica,
Modelos Animales,
Actividad Motora/fisiología,
Contracción Miocárdica/efectos de los fármacos,
Miocardio/patología,
Miocitos Cardíacos/efectos de los fármacos,
Miocitos Cardíacos/fisiología,
NG-Nitroarginina Metil Éster/administración & dosificación,
NG-Nitroarginina Metil Éster/farmacología,
Óxido Nítrico Sintasa/efectos de los fármacos,
Óxido Nítrico Sintasa/metabolismo,
Condicionamiento Físico Animal/fisiología,
Ratas Wistar,
Presión Ventricular/efectos de los fármacos
Anaphylactic shock can be defined as an acute syndrome, and it is the most severe clinical manifestation of allergic diseases. Anaphylactoid reactions are similar to anaphylactic events but differ in the pathophysiological mechanism. Nitric oxide (NO) inhibitors during anaphylaxis suggest that NO might d...
The central nervous system shows limited regenerative capacity after injury. Spinal cord injury (SCI) is a devastating traumatic injury resulting in loss of sensory, motor, and autonomic function distal from the level of injury. An appropriate combination of biomaterials and bioactive substances is curre...
Sistema Nervioso Central/efectos de los fármacos,
Modelos Animales de Enfermedad,
Ensayo de Materiales,
Microfibrillas/química,
Microscopía Electrónica de Rastreo,
Copolímero de Ácido Poliláctico-Ácido Poliglicólico/química,
Ratas Wistar,
Traumatismos de la Médula Espinal/terapia,
Ingeniería de Tejidos/métodos,
Andamios del Tejido,
Ácido Valproico/administración & dosificación
Chagas, Diego Cipriano;
Barros-Oliveira, Maria da Conceição;
Lopes-Costa, Pedro Vitor;
Pereira, Renato de Oliveira;
Melo, Mariella de Almeida;
Costa-Silva, Danylo Rafhael;
Borges, Carine Soares;
Viana, Jackeline Lopes;
Santos, Alesse Ribeiro dos;
Facina, Gil;
Silva, Benedito Borges da.
OBJECTIVES: Aromatase inhibitors are the first-choice drugs for the treatment of hormone sensitive breast cancer. However, in addition to the scarcity of studies, there are controversies about their effects on vaginal epithelial cell proliferation in rats, especially those in persistent estrus. METHODS:...
Abstract Glucosamine is known as anti-inflammatory, antioxidant and as neuroprotective as well as using to treat many of diseases. This work aimed to investigate the remedial effect of glucosamine (20mg/kg b.wt) against the damage induced by a single dose of γ-radiation (8Gy) or aluminium chloride (...
Enfermedades Cardiovasculares/etiología,
Exposición a la Radiación/efectos adversos,
Glucosamina/uso terapéutico,
Encefalopatías/etiología,
Cloruro de Aluminio/efectos adversos,
Encefalopatías/tratamiento farmacológico,
Enfermedades Cardiovasculares/tratamiento farmacológico,
Ratas Wistar,
Encefalopatías/patología,
Enfermedades Cardiovasculares/patología,
Reacción en Cadena de la Polimerasa,
Antiinflamatorios/uso terapéutico,
Modelos Animales de Enfermedad
