The present work studied the adverse effects of maternal exposure of rats to alcohol during lactation, on the development of their offspring. Histometric evaluation by karyometry and of the palatine epithelium of the sucking was performed. Two groups of animals, one coming from mothers exposed to drinkin...
The present study assessed central nervous system (CNS) and immune system changes in murine fetuses after cyclophosphamide (CP) exposure during intrauterine life. A single CP dose of 0, 10, or 20mg/kg body weight was administered by intraperitoneal inj ection to pregnant mice (20/group) on day 11 of gest...
Ciclofosfamida/toxicidad,
Antineoplásicos Alquilantes/toxicidad,
Sistema Nervioso Central/efectos de los fármacos,
Timo/efectos de los fármacos,
Feto/efectos de los fármacos,
Fragmentación del ADN,
Proliferación Celular,
Técnicas In Vitro,
Sistema Nervioso Central/patología,
Timo/patología,
Fotomicrografía
The aim of this study was to present a possible carrier for MTA, monoolein gel, with the objective to maintain this material in the place that was inserted and verify if this procedure is able to optimize its action. The data were evaluated by histomorphometric method and submitted to statistical analysi...
Boron is a chemical element widely used in many industrial activities. Exposure to it affects many organs in mammals, mainly reproductive male organs. This work evaluates boron effect in testis. For this purpose, 12mg Boron/L of drinking water, equivalent to Arica tap water, was given for 42 days to 85 d...
Inúmeras alterações sistêmicas, assim como uso de medicamentos poderão levar a um quadro de hipossalivação. Por sua vez, a redução do fluxo salivar propicia desconforto e aumenta a susceptibilidade a processos infecciosos. Para diminuir a morbidade causada pela hipossalivação propõe-se o uso ...
Objetivos: Quantificar e avaliar os efeitos adversos causados pelo uso de acitretina e metotrexato o tratamento da psoríase. Material e métodos: Foi realizada uma coorte histórica para avaliação de intervenção em pacientes com uso de metotrexato e acitretina para tratamento de psoríase. Resultado...
Estudios Retrospectivos,
Psoriasis/tratamiento farmacológico,
Psoriasis/sangre,
Psoriasis/epidemiología,
Metotrexato/efectos adversos,
Acitretina/efectos adversos,
Metotrexato/uso terapéutico,
Acitretina/uso terapéutico,
Hígado/efectos de los fármacos,
Riñón/efectos de los fármacos,
Médula Ósea/efectos de los fármacos,
Sangre/efectos de los fármacos,
Hipercolesterolemia/inducido químicamente,
Brasil/epidemiología,
51894
Aspartame is a synthetic sweetener consumed by more than half the adult population in 75 countries. Their metabolites can be toxic, principally to the liver and retina, and there are few studies on the use of aspartame in gestation. Twenty pregnant rats were weighed and allocated randomly (n=5 per group)...
Aspartame/toxicidad,
Peso Corporal/efectos de los fármacos,
Peso Fetal/efectos de los fármacos,
Placenta/efectos de los fármacos,
Cordón Umbilical/efectos de los fármacos,
Hígado/efectos de los fármacos,
Cariometría,
Ratas Wistar,
Placenta/patología,
Cordón Umbilical/patología,
Hígado/patología,
Edulcorantes/toxicidad
Ofloxacin presents an ample spectrum of antimicrobial action, including combating Mycobacterium leprae, and is currently employed as a substitute when the use of rifampicin is impossible. The objective of this work was to study alterations in testicular cell nuclei of suckling rats, whose dams were submi...
Effects of graded dosages of methanolic extract of Aspilia Africana were examined on the estrous cycle, uterine weights and histology to determine its effects on the reproductive functions of 25 cyclic female rats. The rats were randomized into five groups A, B, C, D, and E. They were given Omg/kg body w...
A pigmentação de dentes e língua associada ao uso de soluções de clorexedina é um dos efeitos adversos que mais desencoraja o seu uso por tempo prolongado. O objetivo deste estudo foi analisar o efeito da solução para bochecho contendo 0,12% de clorexidina, 0,05% de cetilpiridínio e 0,05% de flu...
