Abstract Objectives: To correlate the basal expression of complement regulatory proteins (CRPs) CD55, CD59, CD35, and CD46 in B-lymphocytes from the peripheral blood of a cohort of 10 patients with rheumatoid arthritis (RA) initiating treatment with rituximab (RTX) with depletion and time repopulation o...
Antirreumáticos/farmacología,
Antirreumáticos/uso terapéutico,
Artritis Reumatoide/sangre,
Artritis Reumatoide/tratamiento farmacológico,
Artritis Reumatoide/inmunología,
Linfocitos B/efectos de los fármacos,
Linfocitos B/metabolismo,
Biomarcadores/sangre,
Esquema de Medicación,
Proteínas Ligadas a GPI/sangre,
Infusiones Intravenosas,
Persona de Mediana Edad,
Rituximab/farmacología,
Rituximab/uso terapéutico,
Resultado del Tratamiento
Abstract Objectives: To evaluate, in an endemic country, the long-term efficacy of latent tuberculosis infection (LTBI) screening and primary prophylaxis in patients with JIA receiving TNF blockers. Methods: This was a retrospective cohort that included JIA patients eligible to anti-TNF therapy. Patien...
Adalimumab/uso terapéutico,
Antirreumáticos/uso terapéutico,
Antituberculosos/uso terapéutico,
Artritis Juvenil/complicaciones,
Artritis Juvenil/tratamiento farmacológico,
Enfermedades Endémicas,
Estudios de Seguimiento,
Infliximab/uso terapéutico,
Tuberculosis Latente/complicaciones,
Tuberculosis Latente/diagnóstico,
Tuberculosis Latente/prevención & control,
Estudios Retrospectivos,
Resultado del Tratamiento
Chakr, Rafael Mendonça da Silva;
Brenol, Claiton;
Ranzolin, Aline;
Bernardes, Amanda;
Dalosto, Ana Paula;
Ferrari, Giovani;
Scalco, Stephanie;
Olszewski, Vanessa;
Kohem, Charles;
Monticielo, Odirlei;
Brenol, João Carlos T;
Xavier, Ricardo M.
Abstract Objective: To compare DMARD use in patients with and without FM over time, including overtreatment and undertreatment rates in both groups. Methods: A prospective cohort study with patients attending an RA outpatient clinic was conducted. Participants were consecutively recruited between March...
Antirreumáticos/uso terapéutico,
Artritis Reumatoide/complicaciones,
Artritis Reumatoide/tratamiento farmacológico,
Brasil,
Estudios de Casos y Controles,
Toma de Decisiones Clínicas,
Progresión de la Enfermedad,
Esquema de Medicación,
Fibromialgia/complicaciones,
Estudios de Seguimiento,
Prescripción Inadecuada/estadística & datos numéricos,
Estimación de Kaplan-Meier,
Persona de Mediana Edad,
Pautas de la Práctica en Medicina/estadística & datos numéricos,
Modelos de Riesgos Proporcionales,
Estudios Prospectivos,
Índice de Severidad de la Enfermedad
Rheumatic diseases are very prevalent, affecting about 7 million people in North America; they affect the musculoskeletal system, often with systemic involvement and potential for serious consequences and limitation on quality of life. Clinical treatment is usually long-term and includes drugs that are c...
Abstract Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute, nonfollicular sterile pustules on an erythematous and edematous base. The most frequently implicated drugs are beta-lactam antibiotics. Hydroxychloroquine has been widely used to treat derm...
ABSTRACT Introduction: There are few studies that carried out a descriptive and trend analysis based on available data from the Unified Health System (SUS) between pre- and post-free dispensing of pharmacological treatment of rheumatoid arthritis (RA) from the perspective of the public health system, in...
Antirreumáticos/economía,
Antirreumáticos/uso terapéutico,
Artritis Reumatoide/economía,
Artritis Reumatoide/terapia,
Brasil,
Estudios Transversales,
Utilización de Instalaciones y Servicios/economía,
Utilización de Instalaciones y Servicios/tendencias,
Costos de la Atención en Salud/tendencias,
Encuestas de Atención de la Salud,
Hospitalización/economía,
Hospitalización/tendencias,
Persona de Mediana Edad,
Programas Nacionales de Salud/economía,
Programas Nacionales de Salud/tendencias
Rituximab is a plausible alternative first-line treatment of ANCA-associated vasculitis. Adverse effects related to its infusion are common and usually have a benign course. However, there have been reports of refractory cardiogenic shock simulating septic shock. We report an 81-year-old male with the di...
Contexto: A AR é uma doença crônica e progressiva, caracterizada pela inflamação da membrana sinovial das articulações. Observa-se um infiltrado linfocítico nas regiões perivasculares e proliferação de células, com consequente angiogênese, hiperplasia sinovial e formação de pannus que lev...
Contexto: A artrite reumatóide (AR) é uma doença autoimune inflamatória e crônica, caracterizada por sinovite periférica e manifestações extra-articulares. De acordo com o Protocolo Clínico e Diretrizes Terapêuticas (PCDT) da Artrite Reumatoide, o tratamento terapêutico deve ser iniciado com o...
ABSTRACT Objective: To evaluate the prevalence of systemic and localized infection by Candida species and its possible association with demographic, clinical and laboratory manifestations and therapy in patients with rheumatic diseases taking TNF blockers. Methods: Consecutive patients with rheumatic d...
Anticuerpos Monoclonales/efectos adversos,
Anticuerpos Monoclonales/uso terapéutico,
Antirreumáticos/efectos adversos,
Antirreumáticos/uso terapéutico,
Candida/aislamiento & purificación,
Candidiasis/epidemiología,
Candidiasis/inmunología,
Huésped Inmunocomprometido,
Persona de Mediana Edad,
Prevalencia,
Enfermedades Reumáticas/tratamiento farmacológico,
Enfermedades Reumáticas/inmunología,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
