ABSTRACT The enzyme glutamic acid decarboxylase (GAD), present in GABAergic neurons and in pancreatic beta cells, catalyzes the conversion of gamma-aminobutyric acid (GABA). The cerebellum is highly susceptible to immune-mediated mechanisms, with the potentially treatable autoimmune cerebellar ataxia ass...
Autoanticuerpos/sangre,
Ataxia Cerebelosa/complicaciones,
Ataxia Cerebelosa/diagnóstico,
Ataxia Cerebelosa/tratamiento farmacológico,
Ataxia Cerebelosa/inmunología,
Glutamato Descarboxilasa/sangre,
Glutamato Descarboxilasa/inmunología,
Inmunoglobulinas Intravenosas/uso terapéutico,
Imagen por Resonancia Magnética,
Estudios Retrospectivos,
Resultado del Tratamiento
ABSTRACT Introduction: The presence of anti-CCP is an important prognostic tool of rheumatoid arthritis (RA). But research is still ongoing on its relationship with disease activity and functional capacity. Objectives: To study the relationship between anti-CCP and disease activity, functional capacity...
Artritis Reumatoide/sangre,
Artritis Reumatoide/diagnóstico por imagen,
Artritis Reumatoide/inmunología,
Artritis Reumatoide/fisiopatología,
Autoanticuerpos/sangre,
Autoanticuerpos/inmunología,
Biomarcadores/sangre,
Estudios Transversales,
Imagen por Resonancia Magnética,
Persona de Mediana Edad,
Péptidos Cíclicos/sangre,
Péptidos Cíclicos/inmunología,
Valor Predictivo de las Pruebas,
Pronóstico,
Factor Reumatoide/sangre,
Índice de Severidad de la Enfermedad
ABSTRACT Objective The aim of this study was to evaluate the association between thyroid function abnormalities and breast cancer and, in particular, the prognostic markers of breast cancer.. Subjects and methods Baseline levels of thyrotropin, free triiodothyronine, free thyroxine and thyroid autoan...
Autoanticuerpos/sangre,
Biomarcadores/sangre,
Neoplasias de la Mama/sangre,
Neoplasias de la Mama/complicaciones,
Neoplasias de la Mama/fisiopatología,
Estudios de Casos y Controles,
Inmunohistoquímica,
Pronóstico,
Glándula Tiroides/irrigación sanguínea,
Glándula Tiroides/fisiopatología,
Tirotropina/sangre,
Tiroxina/sangre,
Triyodotironina/sangre
ABSTRACT The definition of neuromyelitis optica (NMO) is still evolving. In 2015, the International Panel for NMO Diagnosis was convened to develop revised diagnostic criteria. There have been few studies on NMO in the Brazilian population. Objective To describe the characteristics of 34 Brazilian NMO ...
Abstract This study considered a possible relationship between the severity of oral lichen planus (OLP), serum anti-TPO autoantibodies (TPOAb) titer and thyroid disease in OLP patients. Forty-six OLP patients with positive TPOAb results (> 35 IU/ml) who had also been diagnosed with thyroid disease wer...
Autoanticuerpos/sangre,
Biomarcadores/sangre,
Estudios de Casos y Controles,
Interleucina-8/sangre,
Yoduro Peroxidasa/sangre,
Yoduro Peroxidasa/inmunología,
Liquen Plano Oral/inmunología,
Valores de Referencia,
Índice de Severidad de la Enfermedad,
Estadísticas no Paramétricas,
Enfermedades de la Tiroides/inmunología,
Enfermedades de la Tiroides/fisiopatología,
Glándula Tiroides/fisiopatología
Abstract: Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3). Coexistence of autoantibodies of bullous pemphigoid and pemphigus in a patient is ra...
Autoanticuerpos/sangre,
Autoantígenos/sangre,
Biopsia,
Desmogleínas/inmunología,
Glucocorticoides/uso terapéutico,
Inmunoglobulina E/sangre,
Queratosis/tratamiento farmacológico,
Queratosis/inmunología,
Queratosis/patología,
Metilprednisolona/uso terapéutico,
Colágenos no Fibrilares/sangre,
Penfigoide Ampolloso/tratamiento farmacológico,
Penfigoide Ampolloso/inmunología,
Penfigoide Ampolloso/patología,
Úlcera por Presión/patología,
Piel/patología
ABSTRACT Background Celiac disease is a permanent intolerance induced by gluten, which is expressed by T-cell mediated enteropathy, and has a high prevalence in the general population. There is evidence of a strong genetic predisposition to celiac disease. Objective To determine the prevalence of genet...
Autoanticuerpos/sangre,
Donantes de Sangre/estadística & datos numéricos,
Brasil/epidemiología,
Enfermedad Celíaca/epidemiología,
Enfermedad Celíaca/genética,
Estudios Transversales,
Proteínas de Unión al GTP,
Marcadores Genéticos,
Predisposición Genética a la Enfermedad,
Genotipo,
Antígenos HLA-DQ,
Persona de Mediana Edad,
Prevalencia,
Estudios Prospectivos,
Transglutaminasas
ABSTRACT Introduction: Systemic sclerosis (SSc) is an autoimmune disease of the connective tissue characterized by the triad of vascular injury, autoimmunity (cellular and humoral) and tissue fibrosis. It is estimated that musculoskeletal pain is a common complaint of patients with SSc, ranging from 40 ...
Anticuerpos Antiproteína Citrulinada/sangre,
Artritis Reumatoide/sangre,
Artritis Reumatoide/complicaciones,
Artritis Reumatoide/inmunología,
Autoanticuerpos/sangre,
Brasil,
Comorbilidad,
Péptidos Cíclicos/sangre,
Calidad de Vida,
Esclerodermia Sistémica/sangre,
Esclerodermia Sistémica/complicaciones,
Esclerodermia Sistémica/inmunología
Background: Vitamin D deficiency or insufficiency may play a role in the pathogenesis of certain autoimmune diseases. Aim: To measure vitamin D levels in children with Hashimotos thyroiditis (HT) (either with subclinical or marked hypothyroidism) and in healthy controls. Material and Methods: We includ...
25-Hidroxivitamina D 2/sangre,
Autoanticuerpos/sangre,
Enfermedad de Hashimoto/complicaciones,
Deficiencia de Vitamina D/complicaciones,
Autoanticuerpos/inmunología,
Estudios de Casos y Controles,
Enfermedad de Hashimoto/sangre,
Yoduro Peroxidasa/sangre,
Yoduro Peroxidasa/inmunología,
Deficiencia de Vitamina D/sangre,
Deficiencia de Vitamina D/diagnóstico