SUMMARY: Osteoarthritis (OA) caused by ageing joints or as a secondary complication of diabetes is a common health problem. We sought to develop an animal model of OA induced by a combination of the chondrocyte glycolytic inhibitor mono-iodoacetate (MIA) and streptozotocin (STZ), the agent that induces d...
Modelos Animales de Enfermedad,
Osteoartritis de la Rodilla/inducido químicamente,
Osteoartritis de la Rodilla/patología,
Ácido Yodoacético/toxicidad,
Estreptozocina/toxicidad,
Combinación de Medicamentos,
Cartílago Articular/patología,
Cartílago Articular/ultraestructura,
Ratas Sprague-Dawley,
Microscopía Electrónica,
Diabetes Mellitus Experimental,
Cartílago Articular/efectos de los fármacos
The aim of this study was to evaluate the histogical and morphological aspects of the condyle in response to mandibular protrusion induced by composite resin occlusal planes. Thirty five-week-old male Wistar rats were selected and randomly divided in two groups. One group received a composite resin type ...
Abstract Purpose: To investigate the effect of chitosan oligosaccharides (COS) against osteoarthritis (OA) and preliminarily discuss the osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) and RANK expression in a rat OA model. Methods: Thirty-six 6-week-old Male SD rats were randoml...
Cartílago Articular/efectos de los fármacos,
Cartílago Articular/metabolismo,
Quitosano/farmacología,
Modelos Animales de Enfermedad,
Regulación de la Expresión Génica,
Oligosacáridos/farmacología,
Osteoartritis/metabolismo,
Osteoprotegerina/efectos de los fármacos,
Osteoprotegerina/metabolismo,
Ligando RANK/metabolismo,
Ratas Sprague-Dawley
Abstract Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvir...
Abstract Background and objectives: In this study it was aimed to examine the histological and morphometric effects on cartilage structure of intra-articular application of levobupivacaine to the shoulder joint. Methods: In twenty New Zealand adult male rabbits, 35 shoulders were used for the study and...
Anestésicos Locales/administración & dosificación,
Anestésicos Locales/farmacología,
Bupivacaína/administración & dosificación,
Bupivacaína/análogos & derivados,
Bupivacaína/farmacología,
Cartílago Articular/anatomía & histología,
Cartílago Articular/efectos de los fármacos,
Relación Dosis-Respuesta a Droga,
Inyecciones Intraarticulares,
Levobupivacaína,
Conejos,
Articulación del Hombro/anatomía & histología,
Articulación del Hombro/efectos de los fármacos
O tratamento das lesões osteocondrais representa um desafio ao cirurgião ortopédico. Diversas técnicas biológicas visam a restauração do tecido lesionado, estando limitadas a formação de fibrocartilagem ou a dimensão da área a ser restaurada. O transplante alógeno osteocondral representa o ú...
Aim: to determine the effects of sciatic compression and treatment with resistance exercise on the morphology of the ankle joint of Wistar rats. Methods: 32 male rats, aged 10 ± 1 week, weighing 376±22 grams were divided into the following four groups (n=8/group): CG (control), LG (lesion), EG (exerci...
ABSTRACT PURPOSE: To evaluate the usefulness of a knee osteoarthritis model through functional, radiological and microscopic changes of the synovial membrane. METHODS: Forty eight rats were divided randomly into two groups. The first received 0.9% saline in the joint and corresponded to the control gro...
Cartílago Articular/patología,
Ácido Yodoacético/efectos adversos,
Articulación de la Rodilla/fisiopatología,
Osteoartritis de la Rodilla/inducido químicamente,
Membrana Sinovial/patología,
Modelos Animales de Enfermedad,
Hiperalgesia/inducido químicamente,
Hiperalgesia/patología,
Hiperalgesia/fisiopatología,
Inyecciones Intraarteriales,
Ácido Yodoacético/administración & dosificación,
Articulación de la Rodilla/fisiología,
Movimiento,
Osteoartritis de la Rodilla/patología,
Osteoartritis de la Rodilla/fisiopatología,
Ratas Wistar,
Membrana Sinovial/diagnóstico por imagen
ABSTRACT PURPOSE: To compare two different experimental models of osteoarthritis in rabbits: intra-articular collagenase injection and anterior cruciate ligament transection. METHODS: Ten adult rabbits were randomly divided in two groups: COLL (collagenase group) and ACLT (anterior cruciate ligament t...
Ligamento Cruzado Anterior,
Cartílago Articular/patología,
Colagenasas,
Modelos Animales de Enfermedad,
Osteoartritis/patología,
Ligamento Cruzado Anterior/patología,
Ligamento Cruzado Anterior/cirugía,
Cartílago Articular/efectos de los fármacos,
Colagenasas/administración & dosificación,
Inyecciones Intraarteriales,
Articulación de la Rodilla/efectos de los fármacos,
Articulación de la Rodilla/patología,
Ligamentos/patología,
Osteoartritis/etiología,
Distribución Aleatoria
