Results: 42

DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms

An. bras. dermatol; 91 (6), 2016
Abstract The transforming growth factor-beta 1 (TGFβ1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is a ne...

Methylene tetrahydrofolate reductase, transforming growth factor-β1 and lymphotoxin-α genes polymorphisms and susceptibility to rheumatoid arthritis

Rev. bras. reumatol; 56 (5), 2016
ABSTRACT Background: Rheumatoid arthritis is a widely prevalent autoimmune disorder with suggested genetic predisposition. Objectives: The aim of this study is to detect the pattern of genetic polymorphism of methylene tetrahydrofolate reductase (MTHFR C677 T and A1298 C), transforming growth factor-&#...

Diabetes mellitus affects the biomechanical function of the callus and the expression of TGF-beta1 and BMP2 in an early stage of fracture healing

Braz. j. med. biol. res; 49 (1), 2016
Transforming growth factor beta 1 (TGF-β1) and bone morphogenetic protein-2 (BMP-2) are important regulators of bone repair and regeneration. In this study, we examined whether TGF-β1 and BMP-2 expressions were delayed during bone healing in type 1 diabetes mellitus. Tibial fractures were creat...

Effect of EDTA on TGF-β1 released from the dentin matrix and its influence on dental pulp stem cell migration

Braz. oral res. (Online); 30 (1), 2016
Abstract: Bioactive molecules stored in dentin, such as transforming growth factor beta1 (TGF-b1), may be involved in the signaling events related to dental tissue repair. The authors conducted an in vitro evaluation of the amount of TGF-b1 released from dentin slices after treatment with 10% ethylenedia...

Immunohistochemical expression of TGF-β1 and osteonectin in engineered and Ca(OH)2-repaired human pulp tissues

Braz. oral res. (Online); 30 (1), 2016
Abstract The aim of the present study was to evaluate the expression of transforming growth factor-β1 (TGF-β1) and osteonectin (ON) in pulp-like tissues developed by tissue engineering and to compare it with the expression of these proteins in pulps treated with Ca(OH)2 therapy. Tooth slices we...

Clinical and prognostic significance of serum transforming growth factor-beta1 levels in patients with pancreatic ductal adenocarcinoma

Braz. j. med. biol. res; 49 (8), 2016
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-β1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report p...

Immunolocalization of the TGFB1 system in submandibular gland fibrosis after experimental periodontitis in rats

Acta odontol. latinoam; 29 (2), 2016
Saliva is the first barrier to entry of bacteria and viruses into the body. The submandibular glands (SMG) contribute to the maintenance of oral health and regulation of immune/ inflam matory responses. Previous studies suggest that transforming growth factor beta 1 (TGFB1) may contribute to salivary gla...

TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma

Biol. Res; 48 (), 2015
BACKGROUND: Transforming growth factor (TGF)-β is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we analyzed the correlation between transforming growth factor beta 1 (TGF-β1) expression and prognosi...

Padronização de técnica manual para obtenção de plasma rico em plaquetas de bovino

Pesqui. vet. bras; 34 (supl.1), 2014
Para padronização de uma técnica manual para a obtenção de plasma rico em plaquetas (PRP) autólogo em bovinos com custo reduzido (método manual) e de boa qualidade (capacidade de concentrar plaquetas, alta concentração de fatores de crescimento e contaminação reduzida com leucócitos e eritró...

Resveratrol ameliorates diabetes-induced renal damage through regulating the expression of TGF-beta 1, collagen IV and Th17/Treg-related cytokines in rats

West Indian med. j; 63 (1), 2014
OBJECTIVES: This study aimed at detecting the protective effects of resveratrol on diabetes-induced renal damage and on the expression of transforming growth factor-beta 1 (TGF-β1), collagen IV and Th17/Tregrelated cytokines in streptozotocin-induced diabetic rats. METHODS: Twenty diabetic rats were...