Abstract Psoriasis is a chronic inflammatory disease that affects the skin variably, according to genetic and environmental factors. Some patients may benefit from systemic treatment with immunobiological agents, drugs that can be accompanied by several adverse effects. A case of a 58-year-old patient un...
Abstract Herpetic whitlow is a viral infection of the fingers caused by the herpes simplex virus. The disease has a bimodal age distribution, affecting children under 10 years of age and young adults between 20 and 30 years old. It can be easily mistaken for panaritium or bacterial cellulitis. In patient...
SUMMARY: Adriamycin (ADR) is an anthracycline antibiotic used for treatment of many types of cancer. However, its applications may damage to healthy tissues. Chloroquine (CLQ) is an anti-inflammatory agent used in treatment of many inflammation associated diseases such as malaria and rheumatoid arthritis...
Enfermedades Testiculares/inducido químicamente,
Enfermedades Testiculares/tratamiento farmacológico,
Cloroquina/administración & dosificación,
Doxorrubicina/efectos adversos,
Inflamación,
Apoptosis/efectos de los fármacos,
Antibióticos Antineoplásicos/efectos adversos,
Etiquetado Corte-Fin in Situ,
Interleucina-6,
Factor de Necrosis Tumoral alfa,
Inmunohistoquímica,
Ensayo de Inmunoadsorción Enzimática,
Ratas Wistar
SUMMARY OBJECTIVE: Many chronic diseases such as malignancy, cardiovascular diseases, endothelial dysfunction, and autoimmune diseases, which have been shown to be related to vitamin D in various studies; have similar relations with CTRP-9, TNFα, and thiol-disulfide hemostasis. We aimed to contribu...
Isnardi, Carolina A;
Civit, Emma;
García Ciccarelli, Agustín;
Sánchez Alcover, Jimena;
García Salinas, Rodrigo;
Magri, Sebastián;
Albiero, Eduardo;
Gobbi, Carla;
Velozo, Edson;
Soriano, Enrique R;
Brom, Martín;
Zacariaz, Johana;
Strusberg, Ingrid;
Baravalle, Marcos;
Castaños, Sol;
Morales, Liliana;
Paira, Sergio;
Calvo, Romina;
Ortiz, Alberto;
Pérez Alamino, Rodolfo;
Maldonado Ficco, Hernán;
Citera, Gustavo.
Objetivos: Golimumab ha sido aprobado para el tratamiento de pacientes con artritis reumatoidea (AR), artritis psoriásica (APs) y espondiloartritis axial. Sin embargo, los datos provenientes de nuestra región son escasos. El objetivo de este estudio fue evaluar la eficacia, seguridad y sobrevida acumul...
SUMMARY: Amiodarone (AMD), an orally powerful antidysrhythmic medication that has caused hepatotoxicity on long-term administration, is commonly used across the world. Silymarin ameliorative effects (SLM); this research elucidated the magnitude of the damage to the liver tissue in AMD. We divided 24 albi...
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Silimarina/administración & dosificación,
Silimarina/farmacología,
Sustancias Protectoras/administración & dosificación,
Sustancias Protectoras/farmacología,
Amiodarona/toxicidad,
Antiarrítmicos/toxicidad,
Hígado/efectos de los fármacos,
Hígado/enzimología,
Hígado/ultraestructura,
Microscopía Electrónica,
Alanina Transaminasa/análisis,
Aspartato Aminotransferasas/análisis,
Estrés Oxidativo,
Superóxido Dismutasa,
Malondialdehído,
Factor de Necrosis Tumoral alfa,
Interleucina-6,
Ratas Endogámicas
Faria, Ana Paula de;
Ritter, Alessandra M. V;
Santa-Catharina, Arthur;
Souza, Débora P;
Naseri, Estephania P;
Bertolo, Manoel B;
Pioli, Mariana Rodrigues;
Carvalho, Caio C;
Modolo, Rodrigo;
Moreno, Heitor.
Resumo Fundamento: A citocina fator de necrose tumoral alfa (TNF-α) é elevada na hipertensão resistente (HAR), mas os efeitos dos inibidores de TNF-α nessa população ainda são desconhecidos. Objetivos: O objetivo deste estudo foi avaliar se uma única dose de infliximabe controlada por p...
ABSTRACT BACKGROUND: The rates of postoperative endoscopic recurrence (PER) in patients with Crohn's disease (CD) are consistent. Anti-TNF therapy has been increasingly used in the postoperative setting, despite the lack of robust data in the literature on the measurement of trough levels and consequen...
SUMMARY: Acute pancreatitis is a frequent life-threatening inflammatory disease of the pancreas characterized by severe abdominal pain that lasts for days to weeks. We sought to determine whether the antidiabetic and anti-inflammatory drug, metformin can substantially protect against acute pancreatitis i...
Pancreatitis Aguda Necrotizante/tratamiento farmacológico,
Pancreatitis Aguda Necrotizante/inducido químicamente,
Arginina/toxicidad,
Metformina/administración & dosificación,
Peroxidasa/antagonistas & inhibidores,
Interleucina-10/metabolismo,
Modelos Animales de Enfermedad,
Interleucina-10,
Ratas Wistar,
Páncreas/efectos de los fármacos,
Sustancias Protectoras,
L-Lactato Deshidrogenasa/antagonistas & inhibidores,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
