Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed phenotype acute leukemia of T/myeloid lineages with poor prognosis. Moreover, this translocation is detected in 50% of T-ALL patients with gamma/delta T...
Enfermedad Aguda,
Proteína alfa Potenciadora de Unión a CCAAT/genética,
Citometría de Flujo,
Genotipo,
Haploinsuficiencia/genética,
Hematopoyesis/genética,
Leucemia Mieloide Aguda/genética,
Ratones Transgénicos,
Fenotipo,
Factores de Transcripción/genética,
Translocación Genética/genética
Yu, Cheng Hao;
Zhao, Jin Shuang;
Zhao, Hui;
Peng, Teng;
Shen, Dong Cheng;
Xu, Qiu Xia;
Li, Yao;
Webb, R. Clinton;
Wang, Mong Heng;
Shi, Xing Ming;
Peng, Cheng;
Ding, Wei Jun.
The aim of this study was to elucidate the concise effects of a traditional herb pair, Curcumae rhizoma-Sparganii rhizoma (CRSR), on uterine leiomyoma (UL) by analyzing transcriptional profiling. The UL rat model was made by intramuscular injection of progesterone and gavage administration of diethylstil...
Curcuma/química,
Modelos Animales de Enfermedad,
Regulación Neoplásica de la Expresión Génica/efectos de los fármacos,
Leiomioma/tratamiento farmacológico,
Leiomioma/genética,
Leiomioma/metabolismo,
Análisis de Secuencia por Matrices de Oligonucleótidos,
Extractos Vegetales/farmacología,
Radioinmunoensayo,
Ratas Sprague-Dawley,
Rizoma/química,
Factores de Transcripción,
Neoplasias Uterinas/tratamiento farmacológico,
Neoplasias Uterinas/genética,
Neoplasias Uterinas/metabolismo
Dong, Jie;
Zheng, Yongxing;
Fu, Yihan;
Wang, Jinxi;
Yuan, Shasha;
Wang, Yonghua;
Zhu, Qidi;
Ou, Xingqi;
Li, Gezi;
Kang, Guozhang.
BACKGROUND: ADP-glucose pyrophosphorylase (AGPase), the key enzyme in plant starch biosynthesis, is a heterotetramer composed of two identical large subunits and two identical small subunits. AGPase has plastidial and cytosolic isoforms in higher plants, whereas it is mainly detected in the cytosol of gr...
Background: Jatropha curcas L., as an important strategic biofuel resource with considerable economic potential, has attracted worldwide attention. However, J. curcas has yet to be domesticated. Plant height, an important agronomic trait of J. curcas, has not been sufficiently improved, and the genetic r...
Jatropha,
Desarrollo de la Planta,
Nicotiana/genética,
Plantas Modificadas Genéticamente/crecimiento & desarrollo,
Factores de Transcripción,
Dedos de Zinc CYS2-HIS2/genética,
Regulación de la Expresión Génica de las Plantas,
Reguladores del Crecimiento de las Plantas/genética,
Giberelinas,
Triazoles,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Clonación Molecular
Introdução: a epilepsia é uma doença neurológica, cuja prevalência é de 0,5 a 1% na população, sendo que 20 a 30% dos pacientes apresentam crises refratárias ao tratamento medicamentoso. A dieta cetogênica (DC) composta por alto teor de gorduras, baixo teor de carboidratos e quantidade proteic...
Human papillomavirus infection is associated with the development of malignant and benign neoplasms. Approximately 40 viral types can infect the anogenital mucosa and are categorized into high- and low-risk oncogenic human papillomavirus, depending on their association with the development of cervical ca...
OBJECTIVES: To study the relationship between the Asp1104His polymorphism of the nucleotide excision repair gene ERCC5 and treatment sensitivity to oxaliplatin in patients with advanced colorectal cancer (CRC) in China. METHODS: A group of 226 patients in the Department of Gastrointestinal Oncology at Z...
Antineoplásicos/uso terapéutico,
Estudios de Casos y Controles,
Neoplasias Colorrectales/tratamiento farmacológico,
Neoplasias Colorrectales/genética,
Neoplasias Colorrectales/mortalidad,
Proteínas de Unión al ADN/genética,
Endonucleasas/genética,
Genotipo,
Estimación de Kaplan-Meier,
Estadificación de Neoplasias,
Proteínas Nucleares/genética,
Oxaliplatino/uso terapéutico,
Polimorfismo de Nucleótido Simple/genética,
Factores de Transcripción/genética
Bone fracture is a common medical condition, which may occur due to traumatic injury or disease-related conditions. Evidence suggests that microRNAs (miRNAs) can regulate osteoblast differentiation and function. In this study, we explored the effects and mechanism of miR-221 on the growth and migration o...
Células 3T3,
Análisis de Varianza,
Western Blotting,
Diferenciación Celular/fisiología,
Movimiento Celular/fisiología,
Proliferación Celular/fisiología,
Supervivencia Celular/fisiología,
Proteínas de Unión al ADN/sangre,
Proteínas de Unión al ADN/fisiología,
Fracturas Óseas/sangre,
MicroARNs/sangre,
MicroARNs/fisiología,
Osteoblastos/fisiología,
Valores de Referencia,
Factores de Transcripción/sangre
The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid...
Previous studies suggested that chromodomain helicase DNA-binding proteins (CHDs), including CHD 1-8, were associated with several human diseases and cancers including lymphoma, liver cancer, colorectal cancer, stomach cancer, etc. To date, little research on CHD 9 in human cancers has been reported. In ...
Biomarcadores de Tumor/genética,
Biomarcadores de Tumor/metabolismo,
Neoplasias Colorrectales/genética,
Neoplasias Colorrectales/metabolismo,
Neoplasias Colorrectales/patología,
ADN Helicasas,
Proteínas de Unión al ADN/genética,
Proteínas de Unión al ADN/metabolismo,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
Estimación de Kaplan-Meier,
Estadificación de Neoplasias,
Pronóstico,
Transactivadores,
Factores de Transcripción/genética,
Factores de Transcripción/metabolismo
