El glioblastoma multiforme es el subtipo de gliomas más frecuente en adultos, con una pobre sobrevida promedio posterior al diagnóstico incluso si se aplica el tratamiento óptimo. Se ha estudiado marcadores tumorales de buen pronóstico, siendo controversial la expresión del homólogo de fosfatasa y ...
SUMMARY OBJECTIVE: Extracranial metastases of glioblastoma multiforme (GBM) are rare due to the short survival experienced by the patients. Therefore, the natural history of GBM metastases remains elusive. The identification of clinical factors promoting GBM metastases may help elucidate the mechanisms ...
Neoplasias Encefálicas/diagnóstico por imagen,
Neoplasias Encefálicas/mortalidad,
Neoplasias Encefálicas/patología,
Glioblastoma/diagnóstico por imagen,
Glioblastoma/mortalidad,
Glioblastoma/secundario,
Neoplasias Pulmonares/diagnóstico por imagen,
Neoplasias Pulmonares/mortalidad,
Neoplasias Pulmonares/secundario,
Imagen por Resonancia Magnética/métodos,
Estadísticas no Paramétricas,
Factores de Tiempo,
Tomografía Computarizada por Rayos X/métodos
SUMMARY INTRODUCTION: Glioblastoma (GBM) is the most frequent primary malignant tumor from the central nervous system in adults. However, the presence of systemic metastasis is an extremely rare event. The objective of this study was to review the literature, evaluating the possible biological mechanism...
O glioblastoma é um tumor cerebral altamente invasivo e de mau prognóstico, derivado da transformação maligna de células-tronco neurais, células precursoras de oligodendrócitos e astrócitos. As células de glioblastoma expressam o receptor de reconhecimento de padrões (PRR) do tipo toll (TLR)4, ...
ABSTRACT Objective: To evaluate the potential of magnetic hyperthermia using aminosilane-coated superparamagnetic iron oxide nanoparticles in glioblastoma tumor model. Methods: The aminosilane-coated superparamagnetic iron oxide nanoparticles were analyzed as to their stability in aqueous medium and th...
Análisis de Varianza,
Temperatura Corporal,
Neoplasias Encefálicas/terapia,
Línea Celular Tumoral,
Modelos Animales de Enfermedad,
Compuestos Férricos/química,
Compuestos Férricos/uso terapéutico,
Glioblastoma/terapia,
Hipertermia Inducida/métodos,
Mediciones Luminiscentes,
Magnetoterapia/métodos,
Nanopartículas de Magnetita/química,
Nanopartículas de Magnetita/uso terapéutico,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento
Gliomas are the most common form of primary intracranial malignancy, among which astrocytomas are the most frequent. Ectodermal-cortex protein 1 (ENC 1), also known as Nuclear Restricted Protein/Brain (NRP/B), was first characterized as a protein which interacts with the cytoskeleton by binding to actin ...
Introduction Glioblastomas are malignant neoplasms, notorious for their poor
prognosis. We have conducted a survival analysis in a sample of elderly patients
with glioblastomas.
Methods The sample of the present study consisted of elderly patients consecutively
admitted from January 2014 to January 2016 ...
RESUMEN La biología de los gliomas malignos se asocia con el balance de la expresión de las proteínas que controlan de manera positiva o negativa el ciclo celular, la proliferación, la motilidad, la neoformación vascular y el reconocimiento del sistema inmune. La frecuencia de las alteraciones gené...
Background: Patients with Glioblastoma multiforme (GBM) have a five years survival of less than 5%, but the response to chemotherapy with alkylating agents can vary depending on the methylation status of O6-methylguanine-DNA-methyltransferase (MGMT). Genetic testing has limitations for routine use, while...
Biomarcadores de Tumor/metabolismo,
Neoplasias Encefálicas/enzimología,
Glioblastoma/enzimología,
O(6)-Metilguanina-ADN Metiltransferasa/metabolismo,
Biomarcadores de Tumor,
Neoplasias Encefálicas/genética,
Chile,
Regulación Neoplásica de la Expresión Génica,
Glioblastoma/genética,
Inmunohistoquímica,
O(6)-Metilguanina-ADN Metiltransferasa/genética,
Pronóstico,
Estudios Retrospectivos,
Tasa de Supervivencia
Chromatin remodeler proteins exert an important function in promoting dynamic modifications in the chromatin architecture, rendering the transcriptional machinery available to the condensed genomic DNA. Due to this central role in regulating gene transcription, deregulation of these molecular machines ma...
